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This Funding Opportunity Announcement (FOA) encourages applications that will develop novel technologies and/or tools for the isolation and characterization of extracellular vesicles (EVs) of Central Nervous System (CNS) origin. The primary focus of the technology development includes robust and reproducible CNS-EV isolation methods. Specifically, there is a need to establish technologies for the isolation and purification of CNS-EVs from peripheral samples and the characterization of CNS-EV types, cargos, and origin, as well as to validate these methods for further analyses. Validation of these technologies may include the analysis of the full range of EV composition such as RNA, proteins, lipids, and metabolites.

The purpose of this funding opportunity announcement (FOA) is twofold: 1. to accelerate translational and clinical Phase I and II a/b safety and efficacy studies for substantiating measurable functional benefits of probiotic/prebiotic components and/or their combinations; and; 2. to understand the underlying mechanisms of their action(s), and variability in responses to these interventions. This FOA calls for interdisciplinary collaborations across scientific disciplines engaged in microbiome and pro/prebiotic research including, but not limited to: nutritional science, microbiology, virology, microecology and microbiome, genomics, immunology, computational biology, chemistry, bioengineering, as well as integration of omics and computational approaches in DNA technologies.

The solar and heliospheric research communities are dedicated to promoting enhanced understanding of, and predictive capabilities for, solar disturbances that propagate to the Earth. Broad-based, grass-roots associations such as SHINE have developed to focus community effort on these scientific questions. Proposals are solicited for research directly related to topics under consideration and discussion at community workshops organized by SHINE. Information on the current activities of SHINE may be found at the following web site: http://www.shinecon.org

CMMT supports theoretical and computational materials research in the topical areas represented in DMR's Topical Materials Research Programs (these are also variously known as Individual Investigator Award (IIA) Programs, or Core Programs, or Disciplinary Programs), which include: Condensed Matter Physics (CMP), Biomaterials (BMAT), Ceramics (CER), Electronic and Photonic Materials (EPM), Metals and Metallic Nanostructures (MMN), Polymers (POL), and Solid State and Materials Chemistry (SSMC). The CMMT program supports fundamental research that advances conceptual understanding of hard and soft materials, and materials-related phenomena; the development of associated analytical, computational, and data-centric techniques; and predictive materials-specific theory, simulation, and modeling for materials research.Research may encompass the advance of new paradigms in materials research, including emerging data-centric approaches utilizing data-analytics or machine learning. Computational efforts span from the level of workstations to advanced and high-performance scientific computing. Emphasis is on approaches that begin at the smallest appropriate length scale, such as electronic, atomic, molecular, nano-, micro-, and mesoscale, required to yield fundamental insight into material properties, processes, and behavior, to predict new materials and states of matter, and to reveal new materials phenomena. Approaches that span multiple scales of length and time may be required to advance fundamental understanding of materials properties and phenomena, particularly for polymeric materials and soft matter.

Research supported by the Division of Materials Research (DMR) focuses on advancing fundamental understanding of materials, materials discovery, design, synthesis, characterization, properties, and materials-related phenomena. DMR awards enable understanding of the electronic, atomic, and molecular structures, mechanisms, and processes that govern nanoscale to macroscale morphology and properties; manipulation and control of these properties; discovery of emerging phenomena of matter

The purpose of this FOA is to invite applications that investigate aspects of lymphatic vessel physiology, development and pathophysiology related to health and diseases of the digestive system. Studies to understand the factors that control local lymphatic vessel functional anatomy and physiology and development during health or disease in this system and its organs, and the mechanisms by which alterations of lymphatic vessel function affect organ function, are of interest. However, studies with the major focus on immune mechanisms, role of lymphatics in cancer metastasis and study of lymphatic vessels in organs other than those from the digestive system will not be considered responsive.

This Funding Opportunity Announcement (FOA) is associated with the Beau Biden Cancer MoonshotSM Initiative that is intended to accelerate cancer research. The purpose of this FOA is to establish Centers of collaborating investigators with the goal of identifying and advancing research opportunities for translating immunotherapy concepts for children and adolescents with cancer toward clinical applications. Specifically, this FOA targets the following area designated as a scientific priority by the Blue Ribbon Panel (BRP): Recommendation (B) that calls for the establishment of a pediatric immunotherapy translational science network. The network was envisioned by the BRP as focusing on identifying new targets for immunotherapies, developing new pediatric immunotherapy treatment approaches (e.g., cancer vaccines, cellular therapy, combinations of immunotherapy agents, and others), and defining the biological mechanisms by which pediatric tumors evade the immune system. The Pediatric Immunotherapy Discovery and Development Network (PI-DDN) Centers will address and implement these BRP recommendations.

The Nano-Biosensing program is part of the Engineering Biology and Health cluster, which includes also 1) Cellular and Biochemical Engineering; 2) Engineering of Biomedical Systems; 3) Biophotonics; and 4) Disability and Rehabilitation Engineering. The Nano-Biosensing program supports fundamental engineering research on devices and methods for measurement and quantification of biological analytes. Proposals that incorporate emerging nanotechnology methods are especially encouraged. Areas of interest include: Multi-purpose sensor platforms that exceed the performance of current state-of-the-art devices. Novel transduction principles, mechanisms and sensor designs suitable for measurement in practical matrix and sample-preparation-free approaches. These include error-free detection of pathogens and toxins in food matrices, waterborne pathogens, parasites, toxins, biomarkers in body fluids, and others that improve human condition. Nano-biosensors that enable measurement of biomolecular interactions in their native states, transmembrane transport, intracellular transport and reactions, and other biological phenomena. Studies that examine intracellular measurements must include discussion on the significance of the measurement.

I-Corps@Ohio is a statewide program to assist faculty and graduate students from Ohio universities and colleges to validate the market potential of their technologies and validate and launch startup companies. I-Corps@Ohio is modeled after the National Science Foundation's (NSF) successful I-Corps program, which is proven to increase innovation, entrepreneurship, and industry collaboration. The I-Corps@Ohio program is an initiative of the Ohio Department of Higher Education.

The goals of the Network for Computational Nanotechnology (NCN) are to: 1) accelerate the transformation of nanoscience to nanotechnology through the integration of simulation with experimentation; 2) engage an ever-larger and more diverse cyber community sharing novel, high-quality nanoscale computation and simulation research and educational resources; 3) develop open-access, open-source software to stimulate data sharing; and 4) inspire and educate the next-generation workforce. The NCN consists of a stand-alone Cyber Platform, which provides computation, simulation, and education services to over 330,000 researchers, educators, students, and industry members of the nanoscience and engineering community annually worldwide; and Nodes, which develop compelling new computational and simulation tools to disseminate through Cyber Platform (nanoHUB.org) and cultivate communities of users in emerging areas of nanoscale science and engineering.

The Macromolecular, Supramolecular and Nanochemistry (MSN) Program focuses on basic research that addresses fundamental questions regarding the chemistry of macromolecular, supramolecular and nanoscopic species and other organized structures and that advances chemistry knowledge in these areas.  Research of interest to this program will explore novel chemistry concepts in the following topics: (1) The development of novel synthetic approaches to clusters, nanoparticles, polymers, and supramolecular architectures; innovative surface functionalization methodologies; surface monolayer chemistry; and template-directed synthesis.  (2) The study of molecular-scale interactions that give rise to macromolecular, supramolecular or nanoparticulate self-assembly into discrete structures; and the study of chemical forces and dynamics that are responsible for spatial organization in discrete organic, inorganic, or hybrid systems (excluding extended solids).  (3) Investigations that utilize advanced experimental or computational methods to understand or to predict the chemical structure, unique chemical and physicochemical properties, and chemical reactivities that result from the organized or nanoscopic structures.  Research in which theory advances experiment and experiment advances theory synergistically is of special interest.

The Macromolecular, Supramolecular and Nanochemistry (MSN) Program focuses on basic research that addresses fundamental questions regarding the chemistry of macromolecular, supramolecular and nanoscopic species and other organized structures and that advances chemistry knowledge in these areas.  Research of interest to this program will explore novel chemistry concepts in the following topics: (1) The development of novel synthetic approaches to clusters, nanoparticles, polymers, and supramolecular architectures; innovative surface functionalization methodologies; surface monolayer chemistry; and template-directed synthesis.  (2) The study of molecular-scale interactions that give rise to macromolecular, supramolecular or nanoparticulate self-assembly into discrete structures; and the study of chemical forces and dynamics that are responsible for spatial organization in discrete organic, inorganic, or hybrid systems (excluding extended solids).  (3) Investigations that utilize advanced experimental or computational methods to understand or to predict the chemical structure, unique chemical and physicochemical properties, and chemical reactivities that result from the organized or nanoscopic structures.  Research in which theory advances experiment and experiment advances theory synergistically is of special interest.

Recent advances in communications, computation, and sensing technologies offer unprecedented opportunities for the design of cyber-physical systems with increased responsiveness, interconnectivity and automation. To meet new challenges and societal needs, the Energy, Power, Control and Networks (EPCN) Program invests in systems and control methods for analysis and design of cyber-physical systems to ensure stability, performance, robustness, and security. Topics of interest include modeling, optimization, learning, and control of networked multi-agent systems, higher-level decision making, and dynamic resource allocation as well as risk management in the presence of uncertainty, sub-system failures and stochastic disturbances. EPCN also invests in adaptive dynamic programing, brain-like networked architectures performing real-time learning, and neuromorphic engineering. EPCN supports innovative proposals dealing with systems research in such areas as energy, transportation, and nanotechnology. EPCN places emphasis on electric power systems, including generation, transmission, storage, and integration of renewables; power electronics and drives; battery management systems; hybrid and electric vehicles; and understanding of the interplay of power systems with associated regulatory and economic structures and with consumer behavior. Also of interest are interdependencies of power and energy systems with other critical infrastructures. Topics of interest also include systems analysis and design for energy scavenging and alternate energy technologies such as solar, wind, and hydrokinetic. The program also supports innovative tools and test beds, as well as curriculum development integrating research and education. In addition to single investigator projects, EPCN encourages cross-disciplinary proposals that benefit from active collaboration of researchers with complementary skills.

Recent advances in communications, computation, and sensing technologies offer unprecedented opportunities for the design of cyber-physical systems with increased responsiveness, interconnectivity and automation. To meet new challenges and societal needs, the Energy, Power, Control and Networks (EPCN) Program invests in systems and control methods for analysis and design of cyber-physical systems to ensure stability, performance, robustness, and security. Topics of interest include modeling, optimization, learning, and control of networked multi-agent systems, higher-level decision making, and dynamic resource allocation as well as risk management in the presence of uncertainty, sub-system failures and stochastic disturbances. EPCN also invests in adaptive dynamic programing, brain-like networked architectures performing real-time learning, and neuromorphic engineering. EPCN supports innovative proposals dealing with systems research in such areas as energy, transportation, and nanotechnology. EPCN places emphasis on electric power systems, including generation, transmission, storage, and integration of renewables; power electronics and drives; battery management systems; hybrid and electric vehicles; and understanding of the interplay of power systems with associated regulatory and economic structures and with consumer behavior. Also of interest are interdependencies of power and energy systems with other critical infrastructures. Topics of interest also include systems analysis and design for energy scavenging and alternate energy technologies such as solar, wind, and hydrokinetic. The program also supports innovative tools and test beds, as well as curriculum development integrating research and education. In addition to single investigator projects, EPCN encourages cross-disciplinary proposals that benefit from active collaboration of researchers with complementary skills.

The Electronics, Photonics, and Magnetic Devices (EPMD) Program seeks to improve the fundamental understanding of devices and components based on the principles of micro- and nano-electronics, optics and photonics, optoelectronics, magnetics, electromechanics, electromagnetics, and related physical phenomena. The Electronics & Magnetic Devices component of EPMD enables discovery and innovation advancing the frontiers of nanoelectronics, spin electronics, molecular and organic electronics, bioelectronics, biomagnetics, non-silicon electronics, and flexible electronics. It also addresses advances in energy-efficient electronics, sensors, low-noise, power electronics, and mixed signal devices. The Optic & Photonic Devices component of EPMD supports research and engineering efforts leading to significant advances in novel optical sources and photodetectors, optical communication devices, photonic integrated circuits, single-photon quantum devices, and nanophotonics. It also addresses novel optical imaging and sensing applications and solar cell photovoltaics.

The Electronics, Photonics, and Magnetic Devices (EPMD) Program seeks to improve the fundamental understanding of devices and components based on the principles of micro- and nano-electronics, optics and photonics, optoelectronics, magnetics, electromechanics, electromagnetics, and related physical phenomena. The Electronics & Magnetic Devices component of EPMD enables discovery and innovation advancing the frontiers of nanoelectronics, spin electronics, molecular and organic electronics, bioelectronics, biomagnetics, non-silicon electronics, and flexible electronics. It also addresses advances in energy-efficient electronics, sensors, low-noise, power electronics, and mixed signal devices. The Optic & Photonic Devices component of EPMD supports research and engineering efforts leading to significant advances in novel optical sources and photodetectors, optical communication devices, photonic integrated circuits, single-photon quantum devices, and nanophotonics. It also addresses novel optical imaging and sensing applications and solar cell photovoltaics.

The Condensed Matter Physics program supports experimental, as well as combined experiment and theory projects investigating the fundamental physics behind phenomena exhibited by condensed matter systems.  Representative research areas in such systems include: 1) phenomena at the nano- to macro-scale including: transport, magnetic, and optical phenomena; classical and quantum phase transitions; localization; electronic, magnetic, and lattice structure or excitations; superconductivity; and nonlinear dynamics. 2) low-temperature physics: quantum fluids and solids; 1D & 2D electron systems. 3) soft condensed matter: partially ordered fluids, granular and colloid physics, and 4) understanding the fundamental physics of new states of matter as well as the physical behavior of condensed matter under extreme conditions e.g., low temperatures, high pressures, and high magnetic fields.  Questions of current interest that span these research areas are:  How and why do complex macroscopic phenomena emerge from simple interacting microscopic constituents?  What new physics occurs far from equilibrium and why?  What is the physics behind the behavior of matter confined to the nanoscale in one or more dimensions?  What is the physics of spin systems and quantum states of matter that could lead to their coherent manipulation and control?

The Condensed Matter Physics program supports experimental, as well as combined experiment and theory projects investigating the fundamental physics behind phenomena exhibited by condensed matter systems.  Representative research areas in such systems include: 1) phenomena at the nano- to macro-scale including: transport, magnetic, and optical phenomena; classical and quantum phase transitions; localization; electronic, magnetic, and lattice structure or excitations; superconductivity; and nonlinear dynamics. 2) low-temperature physics: quantum fluids and solids; 1D & 2D electron systems. 3) soft condensed matter: partially ordered fluids, granular and colloid physics, and 4) understanding the fundamental physics of new states of matter as well as the physical behavior of condensed matter under extreme conditions e.g., low temperatures, high pressures, and high magnetic fields.  Questions of current interest that span these research areas are:  How and why do complex macroscopic phenomena emerge from simple interacting microscopic constituents?  What new physics occurs far from equilibrium and why?  What is the physics behind the behavior of matter confined to the nanoscale in one or more dimensions?  What is the physics of spin systems and quantum states of matter that could lead to their coherent manipulation and control?

The Communications, Circuits, and Sensing-Systems (CCSS) Program is intended to spur visionary systems-oriented activities in collaborative, multidisciplinary, and integrative engineering research. CCSS supports systems research in hardware, signal processing techniques, and architectures to enable the next generation of cyber-physical systems (CPS) that leverage computation, communication, and algorithms integrated with physical domains. CCSS supports innovative research and integrated educational activities in micro- and nano- electromechanical systems (MEMS/NEMS), communications and sensing systems, and cyber-physical systems. The goal is to design, develop, and implement new complex and hybrid systems at all scales, including nano and macro, that lead to innovative engineering principles and solutions for a variety of application domains including, but not limited to, healthcare, medicine, environmental and biological monitoring, communications, disaster mitigation, homeland security, intelligent transportation, manufacturing, energy, and smart buildings. CCSS also supports integration technologies at both intra- and inter- chip levels, new and advanced radio frequency (RF), millimeter wave and optical wireless and hybrid communications systems architectures, and sensing and imaging at terahertz (THz) frequencies.

The Communications, Circuits, and Sensing-Systems (CCSS) Program is intended to spur visionary systems-oriented activities in collaborative, multidisciplinary, and integrative engineering research. CCSS supports systems research in hardware, signal processing techniques, and architectures to enable the next generation of cyber-physical systems (CPS) that leverage computation, communication, and algorithms integrated with physical domains. CCSS supports innovative research and integrated educational activities in micro- and nano- electromechanical systems (MEMS/NEMS), communications and sensing systems, and cyber-physical systems. The goal is to design, develop, and implement new complex and hybrid systems at all scales, including nano and macro, that lead to innovative engineering principles and solutions for a variety of application domains including, but not limited to, healthcare, medicine, environmental and biological monitoring, communications, disaster mitigation, homeland security, intelligent transportation, manufacturing, energy, and smart buildings. CCSS also supports integration technologies at both intra- and inter- chip levels, new and advanced radio frequency (RF), millimeter wave and optical wireless and hybrid communications systems architectures, and sensing and imaging at terahertz (THz) frequencies.

Nanomanufacturing is the production of useful nano-scale materials, structures, devices and systems in an economically viable manner. The NSF Nanomanufacturing Program supports fundamental research in novel methods and techniques for batch and continuous processes, top-down (addition/subtraction) and bottom-up (directed self-assembly) processes leading to the formation of complex heterogeneous nanosystems. The program supports basic research in nanostructure and process design principles, integration across length-scales, and system-level integration. The Program leverages advances in the understanding of nano-scale phenomena and processes (physical, chemical, electrical, thermal, mechanical and biological), nanomaterials discovery, novel nanostructure architectures, and new nanodevice and nanosystem concepts. It seeks to address quality, efficiency, scalability, reliability, safety and affordability issues that are relevant to manufacturing. To address these issues, the Program encourages research on processes and production systems based on computation, modeling and simulation, use of process metrology, sensing, monitoring, and control, and assessment of product (nanomaterial, nanostructure, nanodevice or nanosystem) quality and performance.

Nanomanufacturing is the production of useful nano-scale materials, structures, devices and systems in an economically viable manner. The NSF Nanomanufacturing Program supports fundamental research in novel methods and techniques for batch and continuous processes, top-down (addition/subtraction) and bottom-up (directed self-assembly) processes leading to the formation of complex heterogeneous nanosystems. The program supports basic research in nanostructure and process design principles, integration across length-scales, and system-level integration. The Program leverages advances in the understanding of nano-scale phenomena and processes (physical, chemical, electrical, thermal, mechanical and biological), nanomaterials discovery, novel nanostructure architectures, and new nanodevice and nanosystem concepts. It seeks to address quality, efficiency, scalability, reliability, safety and affordability issues that are relevant to manufacturing. To address these issues, the Program encourages research on processes and production systems based on computation, modeling and simulation, use of process metrology, sensing, monitoring, and control, and assessment of product (nanomaterial, nanostructure, nanodevice or nanosystem) quality and performance.

Materials processing proposals should focus on manufacturing processes that convert material into a useful form as either intermediate or final composition. These include processes such as extrusion, molding, casting, forming, deposition, sintering and printing. Proposed research should include the consideration of cost, performance, and feasibility of scale-up, as appropriate. Novel processes for the production of nanoscale materials (nanotubes, nanocrystals, etc.) are of interest. Process optimization studies without a fundamental scientific contribution are not supported. Research approaches which exploit knowledge of biological processes for the processing of non-biological materials, as well as the utilization of advanced computing techniques to enable major advances in Materials Engineering and Processing are encouraged.

Materials processing proposals should focus on manufacturing processes that convert material into a useful form as either intermediate or final composition. These include processes such as extrusion, molding, casting, forming, deposition, sintering and printing. Proposed research should include the consideration of cost, performance, and feasibility of scale-up, as appropriate. Novel processes for the production of nanoscale materials (nanotubes, nanocrystals, etc.) are of interest. Process optimization studies without a fundamental scientific contribution are not supported. Research approaches which exploit knowledge of biological processes for the processing of non-biological materials, as well as the utilization of advanced computing techniques to enable major advances in Materials Engineering and Processing are encouraged.

The SNM-IS solicitation seeks proposals that investigate novel scalable nanomanufacturing and integration methods for nano-enabled integrated systems with a clear commercial relevance. Proposals should consider addressing key aspects of the nanomanufacturing value chain comprised of nano-scale building-blocks → complex nanomaterials and nanostructures → functional components and devices → integrated sub-systems and systems

The goal of the Particulate and Multiphase Processes (PMP) program is to support fundamental research on physico-chemical phenomena that govern particulate and multiphase systems, including flow of suspensions, drops and bubbles, granular and granular-fluid flows, behavior of micro- and nanostructured fluids, and self-assembly/directed-assembly processes that involve particulates.  The program encourages transformative research to improve our basic understanding of particulate and multiphase processes with emphasis on research that demonstrates how particle-scale phenomena affect the behavior and dynamics of larger-scale systems.  Although proposed research should focus on fundamentals, a clear vision is required that anticipates how results could benefit important applications in advanced manufacturing, energy harvesting, transport in biological systems, biotechnology, or environmental sustainability.  Collaborative and interdisciplinary proposals are encouraged, especially those that involve a combination of experiment with theory or modeling.  Proposals whose main focus is on the synthesis of particles are not encouraged.

The goal of the Particulate and Multiphase Processes (PMP) program is to support fundamental research on physico-chemical phenomena that govern particulate and multiphase systems, including flow of suspensions, drops and bubbles, granular and granular-fluid flows, behavior of micro- and nanostructured fluids, and self-assembly/directed-assembly processes that involve particulates.  The program encourages transformative research to improve our basic understanding of particulate and multiphase processes with emphasis on research that demonstrates how particle-scale phenomena affect the behavior and dynamics of larger-scale systems.  Although proposed research should focus on fundamentals, a clear vision is required that anticipates how results could benefit important applications in advanced manufacturing, energy harvesting, transport in biological systems, biotechnology, or environmental sustainability.  Collaborative and interdisciplinary proposals are encouraged, especially those that involve a combination of experiment with theory or modeling.  Proposals whose main focus is on the synthesis of particles are not encouraged.

The goal of the Biophotonics program is to explore the research frontiers in photonics principles, engineering and technology that are relevant for critical problems in fields of medicine, biology and biotechnology.  Fundamental engineering research and innovation in photonics is required to lay the foundations for new technologies beyond those that are mature and ready for application in medical diagnostics and therapies.  Advances are needed in nanophotonics, optogenetics, contrast and targeting agents, ultra-thin probes, wide field imaging, and rapid biomarker screening. Low cost and minimally invasive medical diagnostics and therapies are key motivating application goals.

The goal of the Biophotonics program is to explore the research frontiers in photonics principles, engineering and technology that are relevant for critical problems in fields of medicine, biology and biotechnology.  Fundamental engineering research and innovation in photonics is required to lay the foundations for new technologies beyond those that are mature and ready for application in medical diagnostics and therapies.  Advances are needed in nanophotonics, optogenetics, contrast and targeting agents, ultra-thin probes, wide field imaging, and rapid biomarker screening. Low cost and minimally invasive medical diagnostics and therapies are key motivating application goals.