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As defined by the DoD, basic research is "systematic study directed toward greater knowledge or understanding of the fundamental aspects of phenomena and of observable facts without specific applications towards processes or products in mind. It includes all scientific study and experimentation directed toward increasing fundamental knowledge and understanding in those fields of the physical, engineering, environmental, and life sciences related to long-term national security needs. It is farsighted high payoff research that provides the basis for technological progress." (DoD 7000.14-R, vol. 2B, chap. 5, para. 050105.B) The DoD's basic research program invests broadly in many scientific fields to ensure that it has early cognizance of new scientific knowledge.

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals to enable the development of technology for rapid phenotype-based identification of bacterial pathogens in complex environments. Proposed research should represent revolutionary advances in the science, devices, and systems needed for the isolation and characterization of potentially unknown and un-culturable bacteria. Specifically excluded is research that primarily results in incremental improvements to the existing state of practice. Friend or Foe will develop a high throughput screening platform that improves our readiness against new microbial threats through isolation and phenotypic characterization of bacterial pathogenicity.

CISE's Division of Computing and Communication Foundations (CCF) supports research and education projects that develop new knowledge in four core programs: The Algorithmic Foundations (AF) program; The Communications and Information Foundations (CIF) program; The Foundations of Emerging Technologies (FET) program; and The Software and Hardware Foundations (SHF) program.

CISE's Division of Computer and Network Systems (CNS) supports research and education projects that develop new knowledge in two core programs: Computer Systems Research (CSR) program; and Networking Technology and Systems (NeTS) program. Proposers are invited to submit proposals in three project classes, which are defined as follows: Small Projects - up to $500,000 total budget with durations up to three years; Medium Projects - $500,001 to $1,200,000 total budget with durations up to four years; and Large Projects - $1,200,001 to $3,000,000 total budget with durations up to five years.

This solicitation extends the Collaborative Research in Computational Neuroscience program for three years. Proposals for collaborations involving Japan are now supported through a new partnership with the National Institute of Information and Communications Technology. Please see the proposal preparation instructions and country-specific instructions and limitations in Sections V and VIII of this solicitation, and the companion documents published by CRCNS partner agencies referenced in Section VIII. The description of scientific topics and approaches has been updated in Section II of this solicitation. Agency contacts have been updated in Section VIII. Results from prior NSF, NIH, and/or CRCNS support must be included in the Project Description if any PI or co-PI identified on the project has received NSF funding, NIH funding, or CRCNS funding from another participating agency, with a start date in the past five years.

The U.S. Department of Energy's (DOE) Energy Efficiency and Renewable Energy (EERE) Solar Energy Technology Office (SETO) is seeking applications under this Funding Opportunity Announcement (FOA) to fund applied research and development to enable the reduction of the levelized cost of electricity (LCOE) generated by concentrating solar power (CSP) to 6 ¢/kWh-electric or less, without subsidies. This FOA intends to develop integrated thermal system solutions to overcome the temperature limitations of current CSP systems, while lowering capital costs by enabling the use of advanced turbines and achieving a higher overall system efficiency in converting solar thermal energy into electricity. Applications to this FOA are expected to advance individual high temperature components which have been developed at lab scale, and test them as an integrated system at a multi-MW thermal scale that can accept solar thermal energy, store it, and efficiently deliver it to a working fluid at high temperature, representative of a high efficiency power cycle.

The Office of Nuclear Physics (NP), Office of Science (SC), U.S. Department of Energy (DOE), hereby announces its interest in receiving applications for research and development that will allow existing technology candidates to demonstrate down-selection criteria for the next generation of neutrinoless double beta decay measurements.

DARPA is soliciting innovative research proposals in the area of physical design of electronic circuits and systems. Proposed research should investigate innovative approaches that enable revolutionary advances in science, devices, or systems. The Design thrust of the Electronics Resurgence Initiative (ERI): Page 3 Investments will address today's System-On-Chip (SoC) design complexity and cost barriers, creating the environment needed for the next wave of US semiconductor innovation. Programs within this thrust will develop the algorithms and software required to realize a unified layout generator that will enable fully automated "no human in the loop" physical design of SoCs, system-in-packages (SiPs), and printed circuit boards (PCBs) in 24 hours. In parallel, programs will create the building blocks, validation methodologies, and infrastructure required for a scalable open source hardware ecosystem, bringing best practices in software to hardware design.

The MME program supports fundamental research leading to improved manufacturing machines and equipment, and their application in manufacturing processes.  Key goals of the program are to advance the transition of manufacturing from skill-based to knowledge-based activities, and to advance technologies that will enable the manufacturing sector to reduce its environmental and societal impacts.  A focus is on the advancement of manufacturing machines and related systems engineering that will enable energy manufacturing on a large scale.  The program also supports research on additive manufacturing machines and processes encompassing feature scales from microns to meters (nanometer scale additive manufacturing is supported under the Nanomanufacturing program).

The LEAP HI program challenges the engineering research community to take a leadership role in addressing demanding, urgent, and consequential challenges for advancing America's prosperity, health and infrastructure. LEAP HI proposals confront engineering problems that are too complex to yield to the efforts of a single investigator - problems that require sustained and coordinated effort from interdisciplinary research teams, with goals that are not achievable through a series of smaller, short-term projects. LEAP HI projects perform fundamental research that may lead to disruptive technologies and methods, lay the foundation for new and strengthened industries, enable notable improvements in quality of life, or re-imagine and revitalize the built environment.

The LEAP HI program challenges the engineering research community to take a leadership role in addressing demanding, urgent, and consequential challenges for advancing America's prosperity, health and infrastructure. LEAP HI proposals confront engineering problems that are too complex to yield to the efforts of a single investigator --- problems that require sustained and coordinated effort from interdisciplinary research teams, with goals that are not achievable through a series of smaller, short-term projects. LEAP HI projects perform fundamental research that may lead to disruptive technologies and methods, lay the foundation for new and strengthened industries, enable notable improvements in quality of life, or reimagine and revitalize the built environment.

The Division of Molecular and Cellular Biosciences (MCB) has developed a new opportunity to enable researchers with a strong track record of prior accomplishment to pursue a new avenue of research or inquiry. This funding mechanism is designed to facilitate and promote a PI's ability to effective adopt empowering technologies that might not be readily accessible in the PI's current research environment or collaboration network. Transformative research likely spans disciplines and minimizing the practical barriers to doing so will strengthen research programs poised to make significant contributions. The award is intended to allow mid-career or later-stage researchers (Associate or Full Professor, or equivalent) to expand or make a transition in their research programs via a sabbatical leave or similar mechanism of professional development and then develop that research program in their own lab. This award will also enable the PI to acquire new scientific or technical expertise, facilitate the investigator's competitiveness, and potentially lead to transformational impacts in molecular and cellular bioscience.

The Global Innovation Initiative is a joint effort of the United States and the United Kingdom to strengthen global multilateral collaboration through grants to university consortia focusing on science, technology, engineering, and mathematics (STEM)-related issues of global significance that foster cutting-edge multinational research and strengthen institutional international partnerships.

The primary objective is to support scholarships for nuclear science, engineering, technology and related disciplines to develop a workforce capable of supporting the design, construction, operation, and regulation of nuclear facilities and the safe handling of nuclear materials. The nuclear-related discipline supported by this funding is intended to benefit the nuclear sector broadly

DARPA is soliciting innovative research proposals in the area of cyber attribution. The goal of the Enhanced Attribution (EA) program is to develop technologies for generating operationally and tactically relevant information about multiple concurrent independent malicious cyber campaigns, each involving several operators; and the means to share such information with any of a number of interested parties without putting at risk the sources and methods used for collection. Proposed research should investigate innovative approaches that enable revolutionary advances in science, devices, or systems.

The General & Age Related Disabilities Engineering (GARDE) program supports fundamental engineering research that will lead to the development of new technologies, devices, or software that improve the quality of life of persons with disabilities. Research may be supported that is directed toward the characterization, restoration, and/or substitution of human functional ability or cognition, or to the interaction of persons with disabilities and their environment. Areas of particular interest are disability-related research in neuroengineering and rehabilitation robotics. Emphasis is placed on significant advancement of fundamental engineering knowledge that facilitates transformative outcomes. We discourage applications that propose incremental improvements. Applicants are encouraged to contact the Program Director prior to submitting a proposal.

The General & Age Related Disabilities Engineering (GARDE) program supports fundamental engineering research that will lead to the development of new technologies, devices, or software that improve the quality of life of persons with disabilities. Research may be supported that is directed toward the characterization, restoration, and/or substitution of human functional ability or cognition, or to the interaction of persons with disabilities and their environment. Areas of particular interest are disability-related research in neuroengineering and rehabilitation robotics. Emphasis is placed on significant advancement of fundamental engineering knowledge that facilitates transformative outcomes. We discourage applications that propose incremental improvements. Applicants are encouraged to contact the Program Director prior to submitting a proposal.

The General & Age Related Disabilities Engineering (GARDE) program supports fundamental engineering research that will lead to the development of new technologies, devices, or software that improve the quality of life of persons with disabilities. Research may be supported that is directed toward the characterization, restoration, and/or substitution of human functional ability or cognition, or to the interaction of persons with disabilities and their environment. Areas of particular interest are disability-related research in neuroengineering and rehabilitation robotics. Emphasis is placed on significant advancement of fundamental engineering knowledge that facilitates transformative outcomes. We discourage applications that propose incremental improvements. Applicants are encouraged to contact the Program Director prior to submitting a proposal.

The General & Age Related Disabilities Engineering (GARDE) program supports fundamental engineering research that will lead to the development of new technologies, devices, or software that improve the quality of life of persons with disabilities. Research may be supported that is directed toward the characterization, restoration, and/or substitution of human functional ability or cognition, or to the interaction of persons with disabilities and their environment. Areas of particular interest are disability-related research in neuroengineering and rehabilitation robotics. Emphasis is placed on significant advancement of fundamental engineering knowledge that facilitates transformative outcomes. We discourage applications that propose incremental improvements. Applicants are encouraged to contact the Program Director prior to submitting a proposal. 

The McKnight Endowment Fund for Neuroscience supports innovative research designed to bring science closer to the day when diseases of the brain can be accurately diagnosed, prevented, and treated. To this end, the McKnight Endowment Fund for Neuroscience invites letters of intent for the 2014 McKnight Technological Innovations in Neuroscience Awards.

The Advanced Manufacturing (AM) program supports the fundamental research needed to revitalize American manufacturing to grow the national prosperity and workforce, and to reshape our strategic industries. The AM program accelerates advances in manufacturing technologies with emphasis on multidisciplinary research that fundamentally alters and transforms manufacturing capabilities, methods and practices. Advanced manufacturing research proposals should address issues related to national prosperity and security, and advancing knowledge to sustain global leadership.

Cyber-physical systems (CPS) are engineered systems that are built from, and depend upon, the seamless integration of computation and physical components. Advances in CPS will enable capability, adaptability, scalability, resiliency, safety, security, and usability that will expand the horizons of these critical systems. CPS technologies are transforming the way people interact with engineered systems, just as the Internet has transformed the way people interact with information. New, smart CPS drive innovation and competition in a range of application domains including agriculture, aeronautics, building design, civil infrastructure, energy, environmental quality, healthcare and personalized medicine, manufacturing, and transportation. Moreover, the integration of artificial intelligence with CPS creates new research opportunities with major societal implications.