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The Department of Energy's (DOE) Office of Advanced Scientific Computing Research (ASCR) announces its interest in receiving applications to explore of the suitability of various implementations of quantum computing hardware for science applications. This foundational research will facilitate the development of device architectures well-suited for scientific applications of quantum computing and improve our understanding of the advantages and limitations of various approaches to quantum computing for science applications. The purpose of this FOA is to invite applications for foundational research in the following two areas: 1. Exploring the relationship between device architecture and application performance 2. Developing meaningful metrics for evaluating the suitability of quantum computing hardware for science applications Applications may address one or both of these themes. Proposed research should focus on devices that are already available or that become available during the term of the award rather than large-scale, high-fidelity, fault-tolerant machines. Funded teams will be expected to collaborate externally with researchers working to develop applications and algorithms that can expand the frontiers of scientific discovery. Funded teams will also be expected to participate in community engagement activities that support the growth of an active, integrated research community committed to the common goal of developing quantum computing resources for advancing scientific discovery. Topics that are out of scope include: development and optimization of quantum algorithms; development of new candidate qubit systems; schemes based on qubits that have not yet demonstrated high-fidelity gates; schemes to improve the performance and functionality of qubits; quantum transduction; quantum communication, networking, and key distribution; cryptography and cryptanalysis; and logical qubits beyond considerations given to scaling to ~10 qubit devices.

CISE's Division of Computer and Network Systems (CNS) supports research and education projects that develop new knowledge in two core programs: Computer Systems Research (CSR) program; and Networking Technology and Systems (NeTS) program.

CISE's Division of Information and Intelligent Systems (IIS) supports research and education projects that develop new knowledge in three core programs: The Cyber-Human Systems (CHS) program; The Information Integration and Informatics (III) program; and The Robust Intelligence (RI) program. Proposals in the area of computer graphics and visualization may be submitted to any of the three core programs described above.

The MURI program supports basic research in science and engineering at U.S. institutions of higher education (hereafter referred to as "universities") that is of potential interest to DoD. The program is focused on multidisciplinary research efforts where more than one traditional discipline interacts to provide rapid advances in scientific areas of interest to the DoD. As defined in the DoD Financial Management Regulation: Basic research is systematic study directed toward greater knowledge or understanding of the fundamental aspects of phenomena and of observable facts without specific applications towards processes or products in mind. It includes all scientific study and experimentation directed toward increasing fundamental knowledge and understanding in those fields of the physical, engineering, environmental, and life sciences related to long term national security needs. It is farsighted high payoff research that provides the basis for technological progress (DoD 7000.14-R, vol. 2B, chap. 5, para. 050201.B). DoD's basic research program invests broadly in many specific fields to ensure that it has early cognizance of new scientific knowledge.

CISE's Division of Computing and Communication Foundations (CCF) supports research and education projects that develop new knowledge in three core programs: The Algorithmic Foundations (AF) program; The Communications and Information Foundations (CIF) program; and The Software and Hardware Foundations (SHF) program. Proposers are invited to submit proposals in three project classes, which are defined as follows: Small Projects - up to $500,000 total budget with durations up to three years; Medium Projects - $500,001 to $1,200,000 total budget with durations up to four years; and Large Projects - $1,200,001 to $3,000,000 total budget with durations up to five years.

Although invention and proof-of-concept testing of new technologies are a key component of the BRAIN Initiative, to achieve their potential these technologies must also be optimized through feedback from end-users in the context of the intended experimental use. This seeks applications for the optimization of existing and emerging technologies and approaches that have potential to address major challenges associated with recording and manipulating neural activity, at or near cellular resolution, at multiple spatial and temporal scales, in any region and throughout the entire depth of the brain. This FOA is intended for the iterative refinement of emergent technologies and approaches that have already demonstrated their transformative potential through initial proof-of-concept testing, and are appropriate for accelerated development of hardware and software while scaling manufacturing techniques towards sustainable, broad dissemination and user-friendly incorporation into regular neuroscience practice. Proposed technologies should be compatible with experiments in behaving animals, and should include advancements that enable or reduce major barriers to hypothesis-driven experiments. Technologies may engage diverse types of signaling beyond neuronal electrical activity for large-scale analysis, and may utilize any modality such as optical, electrical, magnetic, acoustic or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. Applications are expected to integrate appropriate domains of expertise, including where appropriate biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.

Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative. Although invention and proof-of-concept testing of new technologies are a key component of the BRAIN Initiative, to achieve their potential these technologies must also be optimized through feedback from end-users in the context of the intended experimental use. This FOA seeks applications for the optimization of existing and emerging technologies and approaches that have potential to address major challenges associated with recording and manipulating neural activity, at or near cellular resolution, at multiple spatial and temporal scales, in any region and throughout the entire depth of the brain. This FOA is intended for the iterative refinement of emergent technologies and approaches that have already demonstrated their transformative potential through initial proof-of-concept testing, and are appropriate for accelerated development of hardware and software while scaling manufacturing techniques towards sustainable, broad dissemination and user-friendly incorporation into regular neuroscience practice. Proposed technologies should be compatible with experiments in behaving animals, and should include advancements that enable or reduce major barriers to hypothesis-driven experiments. Technologies may engage diverse types of signaling beyond neuronal electrical activity for large-scale analysis, and may utilize any modality such as optical, electrical, magnetic, acoustic or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. Applications are expected to integrate appropriate domains of expertise, including where appropriate biological, chemical and physical sciences, engineering, computational modeling and statistical analysis. Also listed under R01

In celebrating its 350th anniversary, Merck KGaA, Darmstadt, Germany offers a series of research grants to stimulate innovative research in challenging areas of future importance. Merck KGaA, Darmstadt, Germany intends to provide several research grants of up to EUR 350,000 per year for 3 years in various research areas with the option of extension or expansion. Grants are offered for research in the following areas: Healthy Lives / Drug Discovery: Challenge 1: What is the next game-changing molecule or technology to help cure cancer or autoimmune disease? Life Reimagined / Synthetic Biology: Challenge 1: What is the next generation production technology for biologics? Challenge 2: Can you revolutionize microbiome research? Materials & Solutions: Challenge 1: Can you develop a new generation of intelligent materials? Challenge 2: Can you develop advances in characterization, control and surface chemistry? Challenge 3: Can you develop better atomic layer processes - from modelling to materials? Digitalization / Computing: Challenge 1: How can in-silico research benefit from deep learning or quantum computing?

A well-prepared, innovative science, technology, engineering, and mathematics (STEM) workforce is crucial to the Nation's prosperity and security. Future generations of STEM professionals are a key sector of this workforce, especially in the critical scientific areas described in the Big Ideas for Future NSF Investments. To accelerate progress in these areas, the next generation of STEM professionals will need to master new knowledge and skills, collaborate across disciplines, and shape the future of the human-technology interface in the workplace. As a result, NSF recognizes the need to support development of and research on effective educational approaches that can position the future STEM workforce to make bold advances in these Big Ideas.

NSF INCLUDES (Inclusion across the Nation of Communities of Learners of Underrepresented Discoverers in Engineering and Science) is a comprehensive national initiative designed to enhance U.S. leadership in science, technology, engineering, and mathematics (STEM) discoveries and innovations by focusing on broadening participation in these fields at scale. The vision of NSF INCLUDES is to catalyze the STEM enterprise to collaboratively work for inclusive change, which will result in a STEM workforce that reflects the population of the Nation. The initiative is developing a National Network composed of NSF INCLUDES Design and Development Launch Pilots, NSF INCLUDES Alliances, an NSF INCLUDES Coordination Hub, NSF-funded broadening participation projects, other relevant NSF-funded projects, scholars engaged in broadening participation research, and other organizations that support the development of talent from all sectors of society to build an inclusive STEM workforce. The successful implementation of NSF INCLUDES will result in substantial advances toward a diverse, innovative, and well-prepared STEM workforce to support our Nation's economy and continued U.S. leadership in the global STEM enterprise. It is anticipated that NSF's investment will contribute to new and improved STEM career pathways, policies, opportunities to learn, and practices for equity and inclusion. The initiative will be supported by the NSF INCLUDES Coordination Hub (NSF 17-591) that will provide a framework for communication and networking, network assistance and reinforcement, and visibility and expansion for the NSF INCLUDES National Network as a whole.

The USAFA is seeking unclassified research white papers and proposals (if requested) that do not contain proprietary information. If proprietary information is submitted it is the offerors responsibility to mark the relevant portions of their proposal as specified in USAFA-PASCC-BAA-2016 Amendment 0001. The United States Air Force's Institute for National Security Studies (INSS), in partnership with PASCC, invites white papers and proposals (if requested) for studies in many broad areas related to countering the threat posed by weapons of mass destruction (WMD). The Defense Threat Reduction Agency (DTRA) has requested that USAF INSS/PASCC issue a call for papers soliciting white papers outlining studies or strategic dialogues (also referred to as Track 2 dialogues). WMD are defined as chemical, biological, radiological, and nuclear weapons. With this Fiscal Year 2019 (FY19) call for papers, USAF INSS announces to academia, research institutions, and non-profit organizations it is soliciting white paper for studies and strategic dialogues that will help enable the DoD and the USG to ensure nuclear deterrence and to prepare for and combat WMD and improvised threats. The white papers should propose rigorous, innovative projects that: 1. Facilitate critical engagement between U.S. and foreign subject-matter experts (SMEs) on key WMD, CWMD, or nuclear deterrence issues; 2. Address current and emerging challenges facing CCMDs and DoD; or 3. Expand knowledge or develop new concepts relevant to the national security missions and requirements of DoD and the Armed Services.

The intent of the PRMRP Discovery Award is to support innovative, non-incremental, high-risk/potentially high-reward research that will provide new insights, paradigms, technologies, or applications. Studies supported by this award are expected to lay the groundwork for future avenues of scientific investigation. The proposed research project should include a well-formulated, testable hypothesis based on a sound scientific rationale and study design. The anticipated direct costs budgeted for the entire period of performance for an FY19 PRMRP Discovery Award will not exceed $200,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.

The DARPA Microsystems Technology Office is soliciting research proposals for the development of advanced RF mixed-mode foundry processes, building blocks, and novel high frequency mixed-mode devices on a CMOS fabrication platform. It is expected that such advances will enable new DoD applications including high capacity, robust communications, radars, and precision sensors.

The purpose of this Funding Opportunity Announcement (FOA) is to invite applications for projects that will rapidly and systematically implement new technologies into the HuBMAP Consortium with the goal of accelerating development of a framework for mapping of the human body at single cell resolution. The scope of this FOA encompasses a wide range of technologies, spanning the fields of tissue collection and preservation; high resolution, high content, high-throughput imaging; high sensitivity and high specificity transcriptomics, genomics and proteomics; analysis, and visualization and modelling of multidimension biomolecular data.

he intent of this solicitation is to request proposals from organizations willing to serve as service providers (SPs) within the NSF Innovative High-Performance Computing (HPC) program to provide advanced cyberinfrastructure (CI) capabilities and/or services in production operations to support the full range of computational- and data-intensive research across all of science and engineering (S&E). The current solicitation is intended to complement previous NSF investments in advanced computational infrastructure by provisioning resources, broadly defined in this solicitation to include systems and/or services, in two categories: Category I, Capacity Systems: production computational resources maximizing the capacity provided to support the broad range of computation and data analytics needs in S&E research; and Category II, Innovative Prototypes/Testbeds: innovative forward-looking capabilities deploying novel technologies, architectures, usage modes, etc., and exploring new target applications, methods, and paradigms for S&E discoveries.

In 2016, the National Science Foundation (NSF) unveiled a set of "Big Ideas," 10 bold, long-term research and process ideas that identify areas for future investment at the frontiers of science and engineering (see https://www.nsf.gov/news/special_reports/big_ideas/index.jsp). The Big Ideas represent unique opportunities to position our Nation at the cutting edge of global science and engineering leadership by bringing together diverse disciplinary perspectives to support convergence research. As such, when responding to this solicitation, even though proposals must be submitted to the Office of Integrative Activities, once received, the proposals will be managed by a cross-disciplinary team of NSF Program Directors.

Within Mid-scale RI-1, proposers may submit two types of projects, "Implementation" and "Design". Design and Implementation projects may comprise any combination of equipment, infrastructure, computational hardware and software, and necessary commissioning. Design includes planning (preliminary and final design) of research infrastructure with an anticipated total project cost that is appropriate for future Mid-scale RI-1,Mid-scale RI-2 or MREFC-class investments. Mid-scale RI-1 uses an inclusive definition of implementation, which can include traditional stand-alone construction or acquisition and can include a degree of advanced development leading immediately to final system acquisition and/or construction. Mid-scale RI-1 "Implementation" projects may have a total project cost ranging from $6 million up to below $20 million. Projects must directly enable advances in fundamental science, engineering or science, technology, engineering and mathematics (STEM) education research in one or more of the research domains supported by NSF. Implementation projects may support new or upgraded research infrastructure. Only Mid-scale RI-1 "Design" projects may request less than $6 million, with a minimum request of $600,000 and a maximum request below $20 million as needed to prepare for a future mid-scale or larger infrastructure implementation project.

This Funding Opportunity Announcement (FOA) solicits applications for a single Coordinating Center to support novel data acquisition strategies, data harmonization, analysis and dissemination activities on emerging and current drug abuse trends across the United States. The Coordinating Center will (1) Maintain a Scientific Advisory Group; (2) Maintain and refine an Early Warning Network composed of local experts on drug abuse data from the selected communities, as well as NIDA-supported community-based researchers, to assist in the ongoing monitoring and interpretation of data; (3) Maintain key community-level indicators for monitoring drug abuse trends and early identification of new synthetic drugs and emerging issues including establishing harmonization of indicators and of presentation and analysis of indicators across the selected communities; (4) Continue to identify and maintain novel sources of data including treatment admissions data, national drug use among adults and youth, law enforcement seizures, and drug poisoning death; (5) Conduct cross-site data analyses from the harmonized Coordinating Center data; (6) Continue to disseminate and identify novel ways to execute dissemination and publication plans of results and findings from the Coordinating Center data, including development and maintenance of a website for disseminating data and findings; (7) Conduct webinars on topics of interest to stakeholders; (8) Conduct on the ground epidemiologic investigations on topics of immediate crisis or need, providing functional feedback to impacted communities towards optimizing current and future response; (9) Provide operational, administrative and logistical support for the Coordinating Center data harmonization and dissemination initiative.

In today's increasingly networked, distributed, and asynchronous world, cybersecurity involves hardware, software, networks, data, people, and integration with the physical world. Society's overwhelming reliance on this complex cyberspace, however, has exposed its fragility and vulnerabilities that defy existing cyber-defense measures; corporations, agencies, national infrastructure and individuals continue to suffer cyber-attacks. Achieving a truly secure cyberspace requires addressing both challenging scientific and engineering problems involving many components of a system, and vulnerabilities that stem from human behaviors and choices. Examining the fundamentals of security and privacy as a multidisciplinary subject can lead to fundamentally new ways to design, build and operate cyber systems, protect existing infrastructure, and motivate and educate individuals about cybersecurity.

The intent of this solicitation is to request proposals from organizations willing to serve as service providers (SPs) within the NSF Innovative High-Performance Computing (HPC) program to provide advanced cyberinfrastructure (CI) capabilities and/or services in production operations to support the full range of computational- and data-intensive research across all of science and engineering (S&E). The current solicitation is intended to complement previous NSF investments in advanced computational infrastructure by provisioning resources, broadly defined in this solicitation to include systems and/or services, in two categories: Category I, Capacity Systems: production computational resources maximizing the capacity provided to support the broad range of computation and data analytics needs in S&E research; and Category II, Innovative Prototypes/Testbeds: innovative forward-looking capabilities deploying novel technologies, architectures, usage modes, etc., and exploring new target applications, methods, and paradigms for S&E discoveries