The objective of this award is to provide additional career development support for outstanding Respiratory Therapists (RTs) who conduct research (clinical or translational), including detection, inhalation therapies, clinical care, diagnostics, and therapeutic tools in alpha-1 antitrypsin deficiency (AATD)-related lung disease.

Proposed research projects should be directed toward the molecular biology of pain and/or the development of new analgesics for the management of pain due to terminal illness.

This Funding Opportunity Announcement invites applications from U.S. or African research institutions to plan research training and capacity building programs focused on emerging viral epidemics in collaboration with institutions in Guinea, Liberia, and/or Sierra Leone.The application should propose a collaborative planning process to develop training approaches that will create sustainable research capacity for the early identification, transmission prediction, testing of public health responses, and assessing and addressing long term health sequelae related to emerging viral diseases that have the potential for regional and global pandemics.

The focus of this Funding Opportunity Announcement (FOA) is to better understand how existing non-invasive neuromodulation devices affect brain circuity. This information should shed light on dose/response relationships that could be used for neuroscience applications and clinical interventions.

The purpose of this Funding Opportunity Announcement (FOA) is to support projects to identify and/or validate biomarkers or biomarker combinations leading to improved diagnosis of active pulmonary tuberculosis (TB) in children, including HIV infected children.

This Funding Opportunity Announcement (FOA) encourages research grant applications directed toward the discovery and preclinical testing of novel compounds for the prevention and treatment of nervous system disorders.

 In this Funding Opportunity Announcement (FOA), applications are solicited for: i.) systems biology studies on regulatory and metabolic networks of microbes, microbial consortia, and microbe-plant interactions involved in biogeochemical cycling of carbon, ii.) development and application of -omics approaches to investigate microbial community functional processes involved in carbon cycling in terrestrial ecosystems.

This Funding Opportunity Announcement (FOA) encourages investigator-initiated applications that propose hypothesis-driven research using erythroid cells.  The aim of this program is to support research efforts towards a complete description of the molecular and cellular components of erythropoiesis and how these components function to achieve normal erythropoiesis.  Components include genes that are expressed (transcriptome) in erythroid cells, either during development or during differentiation, chemical changes to DNA and histone proteins (epigenome) and the proteins (proteome) that are translated in erythroid cells, including post-translational modifications or subcellular localizations that are unique to erythroid cells. 

The purpose of this research is to investigate models for linking community pharmacists (e.g., independent, chain, franchise, mail order, retail) to primary care providers to enhance medication review and management in older adults, and examine the potential health benefits of primary care-pharmacy linkages.

The purpose of this FOA is to encourage submission of Exploratory/Developmental Bioengineering Research Grants (EBRG) applications which establish the feasibility of technologies, techniques or methods that: 1) explore a new multidisciplinary approach to a biomedical challenge; 2) are high-risk but have high impact; and 3) develop data that may lead to significant future research. A

The goal of the program is to build a research cohort of one million or more U.S. volunteers who are engaged as partners in a longitudinal, long-term effort to transform the understanding of factors contributing to individual health and disease.

This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for large-scale recording and manipulation of neural activity to enable transformative understanding of dynamic signaling in the nervous system.  In particular, we seek exceptionally creative approaches to address major challenges associated with recording and manipulating neural activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain. 

The goals of this funding opportunity announcement are to support science that will ultimately help: 1) Improve the ability to identify who is at risk for sub-optimal weight loss, weight regain, and short- or long-term adverse metabolic/physiologic or behavioral outcomes based on behavioral or psychological characteristics and 2) Inform the development of new treatment approaches to be used pre and/or post-surgery to minimize risks and improve outcomes or allow for more tailored patient and procedure selection.

The purpose of the project is to advance knowledge of the impact of protection of single versus multiple adjacent properties - in relation to human landscape use patterns and tick exposure locations – to reduce human exposure to ticks infected with Lyme disease spirochetes.

This Funding Opportunity Announcement (FOA) on the Human Immunology Project Consortium (HIPC) solicits applications from single institutions, or consortia of institutions, to participate in a network of human immunology profiling research groups in the area of infectious diseases, including HIV. The purpose of this FOA is to characterize human immune responses/mechanisms elicited by vaccinations, adjuvants or natural infection by capitalizing on recent advances in immune profiling technologies. 

he AFPMB is soliciting pre-proposals for original, innovative research designed to develop new interventions for protection of deployed military personnel from diseases caused by arthropod-borne pathogens and to improve control of filth flies. Diseases of significant concern include malaria, dengue fever, chikungunya fever, and other arboviruses. 

 The purpose of this program is to support the delivery of coordinated and comprehensive high-quality voluntary early childhood home visiting services to eligible families.  This program is administered by HRSA in partnership with the Administration for Children and Families (ACF).

Applications addressing one of the SVS Clinical Research Priorities are particularly encouraged. Small-scale clinical trials and ancillary studies in the setting of existing clinical trials (industry or NIH-supported) will be accepted. Relevant examples include:  · Ancillary studies coupled to existing clinical trials. A letter of support from the primary trial sponsor is required. · Pilot clinical trials of any type · Studies on the natural history of vascular disease, pathophysiology, or mechanisms underlying success or failure of vascular interventions · Application of quality-of-life, functional status, and resource utilization measures to assess the impact of vascular interventions · Development and validation of clinical risk-prediction models or diagnostic tools · Studies addressing the nature of disparities in care and outcomes

The National Eye Institute (NEI) supports large-scale clinical vision research projects, including randomized clinical trials and epidemiologic studies. At the time of submission, applications requesting support for these activities are expected to provide detailed information regarding the study rationale, design, analytic techniques, protocols and procedures, facilities and environment, organizational structure, and collaborative arrangements.

The purpose of this funding opportunity announcement (FOA) is to stimulate mechanistic research on the pathophysiological effects of inhaled nicotine on the respiratory and cardiovascular systems in the context of non-cancer heart and lung diseases.