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The goal of this FOA is to enhance the diversity of the drug abuse research workforce by providing dissertation awards on topics related to the study of basic and clinical neuroscience, development, epidemiology, prevention, treatment, services, or women and sex/gender differences as they relate to drug abuse. This support will enhance the pool of highly talented drug abuse scientists who conduct research within the funding priority areas (http://www.drugabuse.gov/funding/funding-priorities) or in the NIDA strategic plan (https://www.drugabuse.gov/about-nida/2016-2020-nida-strategic-plan). Applications are encouraged from doctoral candidates in a variety of academic disciplines and programs. This program will ultimately facilitate the entry of promising new investigators into the field of drug abuse research and promote transdisciplinary collaborations. This award is for up to two years of support for the completion of the doctoral dissertation research project.

The goal of this FOA is to enhance the diversity of the drug abuse research workforce by providing dissertation awards on topics related to the study of basic and clinical neuroscience, development, epidemiology, prevention, treatment, services, or women and sex/gender differences as they relate to drug abuse. This support will enhance the pool of highly talented drug abuse scientists who conduct research within the funding priority areas (http://www.drugabuse.gov/funding/funding-priorities) or in the NIDA strategic plan (https://www.drugabuse.gov/about-nida/2016-2020-nida-strategic-plan). Applications are encouraged from doctoral candidates in a variety of academic disciplines and programs. This program will ultimately facilitate the entry of promising new investigators into the field of drug abuse research and promote transdisciplinary collaborations. This award is for up to two years of support for the completion of the doctoral dissertation research project.

The following programs have due dates that fall between October 1 - 25, 2013, and these dates are being revised due to the Federal  government shutdown. These revised dates apply whether the proposal is being submitted via the NSF FastLane System or  Grants.gov. Due to compressed proposal deadlines resulting from the shutdown, proposers are advised that they may experience a  delay when contacting IT Help Central with technical support questions. Frequently asked questions regarding these date changes  are available on the Resumption of Operations page on the NSF website at: http://www.nsf.gov/bfa/dias/policy/postshutdown.jsp. 

The purpose of this program is to implement comprehensive HIV prevention programs to reduce morbidity, mortality, and related health disparities. In accordance with the National HIV/AIDS Strategy (http://www.whitehouse.gov/sites/default/files/uploads/NHAS.pdf) and CDC's High-Impact HIV Prevention (HIP) approach (http://www.cdc.gov/hiv/strategy/hihp/index.htm), this FOA focuses on HIV in the nation by reducing new infections, increasing access to care, and promoting health equity. These goals will be achieved by enhancing community-based organizations' capacities to increase HIV testing, link HIV-positive persons to HIV medical care, increase referrals to Partner Services (PS), provide prevention and essential support services for HIV-positive persons and high-risk persons with unknown/negative serostatus, and increase program monitoring and accountability. Standard performance measures for HIV prevention programs that are consistent with the focus of the National HIV/AIDS Strategy on improving performance and accountability are included in this FOA.

Olfaction is an evolutionarily primitive sense critical for survival across the animal kingdom - finding food, searching for mates, or avoiding predation all depend on detecting, identifying, and discriminating odors. Although early steps in olfactory processing are relatively well understood, significant gaps remain in our understanding of higher-order odor representations and processing during on-going behavior. Deciphering the operating principles of olfaction requires the development of innovative and integrative approaches that combine novel theoretical frameworks, improved mathematical models, and novel behavioral paradigms across the phylogenetic spectrum, experimental methodologies, and engineering principles. This solicitation describes an Ideas Lab on "Cracking the Olfactory Code." Ideas Labs are intensive workshops focused on finding innovative solutions to grand challenge problems. The ultimate aim of this Ideas Lab organized by the Biological Sciences (BIO) and the Mathematical and Physical Sciences (MPS) Directorates at the National Science Foundation (NSF) is to facilitate the generation and execution of innovative research projects aimed at understanding the nature of olfactory processing and sensory representations in the brain in general. The aspiration is that mixing researchers from diverse scientific backgrounds will engender fresh thinking and innovative approaches that will transform our understanding of olfactory processing in behavioral contexts while spawning new opportunities to elucidate the general nature of sensory representations in the brain. This multi-directorate program is one element of NSF's multi-year effort towards the goals of the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (http://www.nsf.gov/brain/). US researchers may submit preliminary proposals only via FastLane for participation in the Ideas Lab in which a set of multidisciplinary ideas

The U.S. Army Medical Research and Materiel Command's (USAMRMC) mission is to provide solutions to medical problems of importance to the American Service member at home and abroad, as well as to the general public at large. The scope of this effort and the priorities attached to specific projects are influenced by changes in military and civilian medical science and technology, operational requirements, military threat assessments, and national defense strategies. The extramural research and development programs play a vital role in the fulfillment of the objectives established by the USAMRMC. General information on USAMRMC can be obtained at https://mrmc.detrick.army.mil/. This Fiscal Year 2015 (FY15) Broad Agency Announcement (BAA) is intended to solicit extramural research and development ideas and is issued under the provisions of the Competition in Contracting Act of 1984 (Public Law 98-369), as implemented in Federal Acquisition Regulation (FAR) 6.102(d)(2) and 35.016. In accordance with FAR 6.102, projects funded under this BAA must be for basic and applied research and that part of development not related to the development of a specific system or hardware procurement. Projects must be for scientific study and experimentation directed toward advancing the state-of-the-art or increasing knowledge or understanding rather than focusing on a specific system or hardware solution. Research and development funded through this BAA is intended and expected to benefit and inform both military and civilian medical practice and knowledge. This FY15 BAA is continuously open for a 12-month period, from October 1, 2014 through September 30, 2015, at 11:59 p.m. Eastern Time. Submission of a pre-proposal/pre-application is required and must be submitted through the new electronic Biomedical Research Application Portal (eBRAP) (https://eBRAP.org/). Pre-proposal/pre-applications may be submitted at any time throughout the 12-month period. If the USAMRMC is interested in rece

The National Vaccine Program Office would like to announce the anticipated availability of funds for Fiscal Year (FY) 2018 cooperative agreement awards] under the authority of section 1702(a) of the Public Health Service Act. The FOA will solicit applications for projects conducting research through implementing and evaluating interventions related to fostering informed vaccine decision making by assessing or addressing vaccine confidence or hesitancy, particularly via vaccine education and communication. The work funded by NVPO cannot also be funded by other awards. The 2010 National Vaccine Plan (NVP) recognizes the importance of communication activities that are strategic, science-based, transparent, and culturally appropriate when it comes to utilizing communication to enhance informed vaccine decision making and vaccination acceptance. The National Vaccine Program Office (NVPO) collaborates with federal partners to provide strategic direction for the coordination of the vaccine and immunization enterprise for the National Vaccine Plan (NVP) implementation http://www.hhs.gov/nvpo/vacc _plan/2010%20Plan/nationalvaccineplan.pdf. NVPO will partner with 2-3 organizations to collaborate on projects that will fall specifically under goal 3 of the NVP (i.e., support communications to enhance informed vaccine decision-making) as well as within the recommendations of the National Vaccine Advisory Committee June 2015 Report: Assessing the State of Vaccine Confidence in the United States: Recommendations from the National Vaccine Advisory Committee. https://www.hhs.gov/sites/default/files/nvpo/nvac/reports/nvac-vaccine-confidence-public-health-report-2015.pdf. That report emphasized the importance of developing measurement tools, as well as interventions for supporting healthcare providers, communities, and policies which foster confidence in vaccines.

The overarching goal of this FOA is to add informatics capabilities to the Common Fund program, Illuminating the Druggable Genome IDG; https://commonfund.nih.gov/idg/. The IDG consortium's purpose is to facilitate the unveiling of the functions of selected understudied proteins in the Druggable Genome using experimental and informatics approaches. Currently, this research consortium is composed of multiple Data and Resource Generation Centers (DRGCs), a Knowledge Management Center (KMC), and a Resource Dissemination and Outreach Center (RDOC). The purpose of this specific FOA is to solicit applications to build a set of Cutting Edge Informatics Tools (CEITs) that will augment the capability of the KMC as well as the broader IDG Consortium in the following ways: (1) by developing and deploying tools to enhance the community's ability to process, analyze, and visualize IDG data, (2) to prioritize new data resources and methods to be incorporated into Pharos https://pharos.nih.gov/idg/index that will strengthen predictions about physiological and disease associations around the understudied proteins, and (3) by developing methods to prioritize understudied IDG families (non-olfactory GPCRs, protein kinases, and ion channels) for deeper study using experimental assays both within the IDG pipeline or by the larger community.

This Funding Opportunity Announcement (FOA) encourages collaborative research applications on drug abuse and addiction that: 1. Take advantage of unusual opportunities that exist outside the United States to access talent, resources, populations, or environmental conditions in other countries that will speed scientific discovery 2. Describe how the research will significantly advance U.S. health sciences 3. Demonstrate specific relevance to the NIDA mission and objectives. To determine whether your research plan is relevant to the NIDA mission and objectives, review the NIDA Strategic Plan (https://www.drugabuse.gov/about-nida/2016-2020-nida-strategic-plan). Where feasible, applications should address NIDA's international scientific priority areas (https://www.drugabuse.gov/international/research-priorities) 4. Include an investigator from a U.S. institution and a non-U.S. citizen partner living and working in another country.

This Funding Opportunity Announcement (FOA) encourages collaborative research applications on drug abuse and addiction that: 1. Take advantage of unusual opportunities that exist outside the United States to access talent, resources, populations, or environmental conditions in other countries that will speed scientific discovery 2. Describe how the research will significantly advance U.S. health sciences 3. Demonstrate specific relevance to the NIDA mission and objectives. To determine whether your research plan is relevant to the NIDA mission and objectives, review the NIDA Strategic Plan (https://www.drugabuse.gov/about-nida/2016-2020-nida-strategic-plan). Where feasible, applications should address NIDAs international scientific priority areas (https://www.drugabuse.gov/international/research-priorities) 4. Include an investigator from a U.S. institution and a non-U.S. citizen partner living and working in another country.

The "3-D Retina Organoid'' Challenge (the "Challenge''), is an ideation Challenge in which the National Eye Institute (NEI; http://www.nei.nih.gov/), part of the National Institutes of Health (http://www.nih.gov(link is external)), is asking for ideas to maximize the physiological relevance of 3-D human retina culture systems. Currently, retina culture models do not capture the complexity of the human retina. The goal of the Challenge is to transform innovative ideas into concrete concepts to develop new in vitro 3-D human retina models that recapitulate the organization and function of the human retina. NEI intends to follow this challenge with a follow-on but distinct Reduction to Practice Challenge, which will aim to invoke scientific and technological development of the model system. Technological breakthroughs in this arena could allow researchers and physicians to better understand, diagnose, and treat retinal diseases.

The purpose of this Funding Opportunity Announcement (FOA) is to fill gaps in our understanding of (a) the impact of substance abuse on HIV, HIV/HCV co-infection associated disease progression, (b) the pathogenic interactions between HIV and hepatitis C virus, (c) hepatic and non-hepatic co-morbidities associated with HIV/HCV-co-infections in people with substance abuse disorders (SUDs), and (d) the effectiveness of interferon-free direct acting antiviral (DAAs) drug regimens to treat HIV/HCV co-infections in people with SUDs. This FOA is informed by priority area in the NIH HIV/AIDS Research Priorities and Guidelines for Determining AIDS Funding: https://grants.nih.gov/grants/guide/notice-files/NOT-OD-15-137.html and the HHS National Viral Hepatitis Action Plan 2017-2020: https://www.hhs.gov/hepatitis/blog/2017/01/19/updated-national-viral-hepatitis-action-plan-2017-2020.html

The Instrument Development for Biological Research (IDBR) Program supports the development, production, and distribution of novel instrumentation that addresses demonstrated needs in biological research in areas supported by NSF Biology programs (see http://www.nsf.gov/bio). These systems would benefit a broad user community through mass distribution of the technology. Interdisciplinary collaborations are strongly encouraged, as are partnerships with U.S. industries that can facilitate knowledge transfer, commercialization and broad utilization in the research community. The program accepts two types of proposals:Type A - Innovation: Proposals for the development of novel instrumentation that provides new research capabilities or, where appropriate, that significantly improves current technologies by at least an order of magnitude in fundamental aspects such as accuracy, precision, resolution, throughput, flexibility, breadth of application, costs of construction or operation, or user-friendliness.Type B - Bridging: Proposals for transforming ‘one of a kind' prototypes or high-end instruments into devices that are broadly available and utilizable without loss of capacity. If appropriate, PIs should seek SBIR/STTR Program, or similar support mechanism for implementation of broad distribution following an IDBR award.

Biological and Environmental Research (BER) of the Office of Science (SC), U.S. Department of Energy (DOE) hereby announces its interest in receiving applications for research of interest to the Genomic Science Program (http://genomicscience.energy.gov) in the following research areas: a) Integrating large-scale systems biology data to model, design, and engineer microbial systems for the production of biofuels and bioproducts: Interdisciplinary approaches to develop innovative, high-throughput modeling, genome-wide design and editing, and engineering technologies for a broad range of microbes relevant for the production of biofuels and bioproducts from biomass. b) Plant systems design for bioenergy: To develop novel technologies for genome-scale engineering to re-design bioenergy crops that can grow in marginal environments while producing high yield of biomass that can be easily converted to biofuels and bioproducts. Applications should include strategies to address biocontainment, minimizing risks of potential release of engineered organisms into the environment or other unintended outcomes.

Biological and Environmental Research (BER) of the Office of Science (SC), U.S. Department of Energy (DOE) hereby announces its interest in receiving applications for research of interest to the Genomic Science Program (http://genomicscience.energy.gov) in the following research areas: a) Integrating large-scale systems biology data to model, design, and engineer microbial systems for the production of biofuels and bioproducts: Interdisciplinary approaches to develop innovative, high-throughput modeling, genome-wide design and editing, and engineering technologies for a broad range of microbes relevant for the production of biofuels and bioproducts from biomass. b) Plant systems design for bioenergy: To develop novel technologies for genome-scale engineering to re-design bioenergy crops that can grow in marginal environments while producing high yield of biomass that can be easily converted to biofuels and bioproducts. Applications should include strategies to address biocontainment, minimizing risks of potential release of engineered organisms into the environment or other unintended outcomes.

This Funding Opportunity Announcement (FOA) issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) invites submission of investigator-initiated program project applications. The proposed programs should address scientific areas relevant to the NIDDK mission including diabetes, endocrine and metabolic diseases, digestive diseases and nutrition, and kidney, urologic and hematologic diseases, as well as new approaches to prevent, treat and cure these diseases, including clinical research. A description of NIDDK scientific program areas can be found at http://www2.niddk.nih.gov/Funding/default.htm.

The purpose of this FOA is to support projects to develop tools and strategies for studying: 1. the three dimensional architecture of the nucleus in relationship to the topography of nuclear bodies and transcriptional machineries, 2. the structure and function of poorly characterized nuclear structures, or 3. the role of specialized proteins and RNAs in the assembly, organization, and function of nuclear bodies, nuclear structures, and specialized subnuclear domains. - See more at: http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-14-008.html#sthash.HQemmZlU.dpuf

This solicitation describes the first phase of a new NSF program to support transformative and integrative research that will accelerate understanding of neural and cognitive systems. NSF seeks exceptional proposals that are bold, potentially risky, and transcend the perspectives and approaches typical of disciplinary research programs. This multi-directorate program is one element of NSF’s broader aim to foster innovation in Cognitive Science and Neuroscience, a multi-year effort that includes NSF’s participation in the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (http://www.nsf.gov/brain/). For FY 2015, this competition is organized around two research themes: Neuroengineering and Brain-Inspired Concepts and Designs and Individuality and Variation. Within each theme, general advances in theory and methods, technological innovations, educational approaches, enabling research infrastructure, and workforce development are all of significant interest.

The Office of Biological and Environmental Research (BER) of the Office of Science (SC), U.S. Department of Energy (DOE), hereby announces its interest in receiving applications for research that supports the Genomic Science research program (http://genomicscience.energy.gov). In this FOA, applications are requested for: i) Research to advance the development of promising new model organisms relevant to biofuels production , ii) development of novel microbial functional capabilities and biosynthetic pathways relevant to the production of advanced biofuels and the development of strategies to overcome associated metabolic challenges resulting from pathway modification, and iii) development of novel analytical technologies or high-throughput screening approaches relating to research in bullets i and ii.

This Funding Opportunity Announcement (FOA) is limited to those Program Director(s)/Principal Investigator(s) of Rare Diseases Clinical Research Consortia (RDCRC) who received an NINDS award under the Rare Diseases Clinical Research Network (RDCRN) program through RFA-TR-13-002, or an NCI award through RFA-OD-08-001. The purpose of this limited competition FOA is to allow these NINDS- and NCI-awarded consortia an opportunity to compete for another four years of participation in the RDCRN. The RDCRN is a collaborative and coordinated network of Clinical Research Consortia comprised of investigators and patient advocacy groups committed to investigation of rare diseases working in partnership with a Data Management Coordinating Center (http://grants.nih.gov/grants/guide/rfa-files/RFA-TR-13-003.html) to enhance communication and sharing of resources in a multidisciplinary approach. This FOA intends to support: 1) collaborative clinical research in rare diseases, including longitudinal studies of individuals with rare diseases, clinical studies and/or clinical trials; 2) career development and advancement opportunities for clinical investigators in rare diseases research; 3) pilot/demonstration (proof of concept) clinical research projects; and 4) access to information related to rare diseases for basic and clinical researchers, physicians, patients, and the lay public.

The purpose of this Funding Opportunity Announcement (FOA) is to continue the SEARCH for Diabetes in Youth Study. The overarching goal of SEARCH is to provide population-based data on the incidence and prevalence of diabetes and its complications in U.S. youth. SEARCH has recruited a cohort of youth with diabetes who have been followed longitudinally. The purpose of this FOA is to continue follow-up of the SEARCH cohort to understand the clinical course of youth-onset diabetes, including the incidence of acute and chronic complications, including mortality, and processes of care and quality of life.  - See more at: http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-14-508.html#sthash.WZygd0KM.dpuf