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This Funding Opportunity Announcement (FOA) encourages Research Project Grant (R01) applications to study molecular and cellular mechanisms of tissue injury and repair associated with alcohol use in humans. Excessive alcohol consumption has the potential to adversely affect multiple organ systems including the liver, brain, heart, pancreas, lung, kidney, endocrine and immune systems, as well as bone and skeletal muscle. In addition, there is accumulating evidence that long term alcohol consumption is associated with reduced host capacity for recovery and repair following trauma. The mechanisms for these alcohol-induced effects on tissue injury and repair are currently not fully understood. NIAAA is especially interested in integrative research that elucidates alcohols effects on complex mechanisms of injury and repair that are either common or specific to each organ system. This FOA also encourages the study of alcohols effect on stem cells, embryonic development, and regeneration. Also encourages are studies on molecular and cellular actions of moderate alcohol consumption. A better understanding of these underlying mechanisms may provide new avenues for developing more effective and novel approaches for prognosis, diagnosis, intervention, and treatment of alcohol-induced organ damage.

This Funding Opportunity Announcement (FOA) encourages Exploratory/Developmental Research Grant Award (R21) applications to study molecular and cellular mechanisms of tissue injury and repair associated with alcohol use in humans. Excessive alcohol consumption has the potential to adversely affect multiple organ systems including the liver, brain, heart, pancreas, lung, kidney, endocrine and immune systems, as well as bone and skeletal muscle. In addition, there is accumulating evidence that long term alcohol consumption is associated with reduced host capacity for recovery and repair following trauma. The mechanisms for these alcohol-induced effects on tissue injury and repair are currently not fully understood. NIAAA is especially interested in integrative research that elucidates alcohols effects on complex mechanisms of injury and repair that are either common or specific to each organ system. This FOA also encourages the study of alcohols effect on stem cells, embryonic development, and regeneration. Also encouraged are studies on molecular and cellular actions of moderate alcohol consumption. A better understanding of these underlying mechanisms may provide new avenues for developing more effective and novel approaches for prognosis, diagnosis, intervention, and treatment of alcohol-induced organ damage.

The National Institute on Drug Abuse (NIDA) will solicit proposals from qualified organizations capable of maintaining and expanding the NIDA Center for Genetic Studies. In this effort, the contractor will be required to: (1) Receive de-identified clinical, diagnostic, pedigree structure, environmental exposure information and other phenotypic data along with blood samples or other biospecimens from funded grants and/or contracts supporting research on the genetics of addiction and addiction vulnerability; (2) Process these data and materials to create databases, serum, DNA, RNA, and cell lines; (3) Widely distribute all data and materials in the NIDA Human Genetics Initiative to qualified investigators in the scientific community in a cost effective manner; (4) Maintain storage of data and biomaterials; (5) As stipulated by NIDA staff, perform microarray typing on pre-existing and/or new de-identified biospecimens; (6) As stipulated by NIDA staff, perform high-throughput sequencing on pre-existing and/or new de-identified biospecimens for genomic and/or epigenomic analyses; (7) Support the creation of reprogrammed cellular derivatives, such as induced pluripotent stem cells (iPSCs) to facilitate the molecular and cellular study of brain development and addiction processes; (8) Create a cyberinfrastructure that enables interoperability and full access to distributed data, software and other information science resources as well as research summaries and outbound links for all addiction related studies available through the NIH database of Genotype and Phenotype (dbGaP) system; and (9) Faciliate NIDA genetic studies data (both genotype and phenotype) being uploaded into NIH databases such as BioSample, and the dbGaP systems.

The purpose of this funding opportunity announcement (FOA) is to support hypothesis-testing research on the systems, cellular and/or molecular mechanisms and consequences of TDP-43 proteinopathy in common dementias using whole animal models, animal/human cellular model systems, as well as postmortem tissue and other biospecimens. Research on TDP-43 proteinopathy in common dementias, including the clinical syndrome of Alzheimer's disease (AD), multiple etiology dementias (MED) and related dementia syndromes is the focus of this FOA. In addition, comparative studies of TDP-43 proteinopathy in common and rare neurodegenerative diseases, as well as during normal aging and in pre-symptomatic disease stages are within scope.

Age is the number one risk factor for diagnosis of many age-related lung diseases, including COPD and pulmonary fibrosis. Despite this, little is known regarding the interactions that likely occur between the molecular and cellular mechanisms of disease and the changes in molecules and cells that can be attributed to normal aging. In fact, very little is known about the normal aging process in the lung at the cellular and molecular level. In 2015, the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute on Aging (NIA) co-sponsored a workshop that identified a major knowledge gap in the understanding of normal lung aging in humans, as well as the need to develop a map of molecular changes that occur during normal aging in the lung that can serve as a reference for studies of age-related lung diseases.

This Funding Opportunity Announcement (FOA) is associated with the Beau Biden Cancer MoonshotSM Initiative that is intended to accelerate cancer research. The purpose of this FOA is to promote research that results in a comprehensive view of the dynamic, multidimensional tumor ecosystem. Specifically, this FOA targets the following area designated as a scientific priority by the Blue Ribbon Panel (BRP): Generation of Human Tumor Atlases. For the purposes of this FOA, a human pre-cancer atlas is defined as a multidimensional cellular, morphological and molecular mapping of human pre-malignant tumors, complemented with critical spatial information (at cellular and/or molecular level) that facilitate visualization of the structure, composition, and multiscale interactions within the tumor ecosystem over time resulting in progression or regression of the tumors.

The Science of Learning program supports potentially transformative basic research to advance the science of learning. The goals of the SL Program are to develop basic theoretical insights and fundamental knowledge about learning principles, processes and constraints. Projects that are integrative and/or interdisciplinary may be especially valuable in moving basic understanding of learning forward but research with a single discipline or methodology is also appropriate if it addresses basic scientific questions in learning.   The possibility of developing connections between proposed research and specific scientific, technological, educational, and workforce challenges will be considered as valuable broader impacts, but are not necessarily central to the intellectual merit of proposed research. The program will support  research addressing learning in a wide range of domains at one or more levels of analysis including: molecular/cellular mechanisms; brain systems; cognitive affective, and behavioral processes; and social/cultural influences. The program supports a variety of methods including: experiments, field studies, surveys, secondary-data analyses, and modeling.

The Science of Learning program supports potentially transformative basic research to advance the science of learning. The goals of the SL Program are to develop basic theoretical insights and fundamental knowledge about learning principles, processes and constraints. Projects that are integrative and/or interdisciplinary may be especially valuable in moving basic understanding of learning forward but research with a single discipline or methodology is also appropriate if it addresses basic scientific questions in learning.   The possibility of developing connections between proposed research and specific scientific, technological, educational, and workforce challenges will be considered as valuable broader impacts, but are not necessarily central to the intellectual merit of proposed research. The program will support  research addressing learning in a wide range of domains at one or more levels of analysis including: molecular/cellular mechanisms; brain systems; cognitive affective, and behavioral processes; and social/cultural influences. The program supports a variety of methods including: experiments, field studies, surveys, secondary-data analyses, and modeling.

Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative.  This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for large scale recording and manipulation of neural activity to enable transformative understanding of dynamic signaling in the nervous system.  In particular, we seek exceptionally creative approaches to address major challenges associated with recording and manipulating neural activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain.  It is expected that the proposed research may be high-risk, but if successful could profoundly change the course of neuroscience research.

Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative.  This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for large scale recording and manipulation of neural activity to enable transformative understanding of dynamic signaling in the nervous system.  In particular, we seek exceptionally creative approaches to address major challenges associated with recording and manipulating neural activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain.  It is expected that the proposed research may be high-risk, but if successful could profoundly change the course of neuroscience research.

The Biotechnology and Biochemical Engineering (BBE) program supports fundamental engineering research that advances the understanding of cellular and biomolecular processes in engineering biology and eventually leads to the development of enabling technology for advanced manufacturing and/or applications in support of the biopharmaceutical, biotechnology, and bioenergy industries, or with applications in health or the environment.  A quantitative treatment of biological and engineering problems of biological processes is considered vital to successful research projects in the BBE program.

The Biotechnology and Biochemical Engineering (BBE) program supports fundamental engineering research that advances the understanding of cellular and biomolecular processes in engineering biology and eventually leads to the development of enabling technology for advanced manufacturing and/or applications in support of the biopharmaceutical, biotechnology, and bioenergy industries, or with applications in health or the environment.  A quantitative treatment of biological and engineering problems of biological processes is considered vital to successful research projects in the BBE program. 

The goal of this Funding Opportunity Announcement (FOA) is to support innovative research focused on understanding the molecular and cellular mechanisms underlying the heterogeneity and multifactorial nature of Alzheimer's disease (AD) with the potential to create new or challenge existing scientific paradigms. This FOA encourages individual or collaborative research projects that propose innovative approaches to understand the complex biology of AD aimed to fill critical knowledge gaps.

In emerging areas of technology at the interface between fields such as the engineering of biology and cellular biomanufacturing, including the field of synthetic biology, there is an even greater need for collaborative precompetitive research that will ensure the success of these nascent technology areas. In particular, research that contributes to the establishment of standards for production; provides tools for the assessment of quality, robustness and stability of the process and product; and develops metrics that will facilitate risk assessment associated with a regulatory framework, will be essential for the eventual commercialization of products from the engineering of biology.

TheCellular and Biochemical Engineering(CBE)program is part of theEngineering Biology and Healthcluster, which also includes: 1) the Biophotonics program; 2) the Biosensing program; 3) the Disability and Rehabilitation Engineering program; and 4) the Engineering of Biomedical Systems program. TheCellular and Biochemical Engineering program supports fundamental engineering research that advances understanding of cellular andbiomolecular processes. CBE-funded research may lead to the development of enabling technology for advanced biomanufacturing in support of the therapeutic cell, biochemical, biopharmaceutical, and biotechnology industries. Fundamental to many research projects in this area is the understanding of how biomolecules, subcellular systems, cells, and cell populations interact, and how those interactions lead to changes in structure, function, and behavior. A quantitative treatment of problems related to biological processes is considered vital to successful research projects in the CBE program. The program encourages highly innovative and potentially transformative engineering research leading to novel bioprocessing and biomanufacturing approaches. The CBE program also encourages proposals that effectively integrate knowledge and practices from different disciplines while incorporating ongoing research into educational activities.

This Funding Opportunity Announcement (FOA) encourages research grant applications directed toward the discovery of the impact of alterations associated with complex brain disorders on the fundamental cellular and molecular substrates of neuronal function. The present announcement seeks R01 applications. ALSO listed (R21)

It has been suggested that generic iron complex formulations could have higher levels of labile iron, leading to the formation of a greater amount of non-transferrin bound iron (NTBI) in vivo than the reference listed drug (RLD) that would potentiate oxidative stress and inflammation, then resulting in direct cellular damage. The objectives of this study are to evaluate various in-vitro methods of determining labile iron in the parenteral iron complex formulations and develop a bio-relevant in-vitro method to predict the amount of NTBI in vivo. Such a predictive in-vitro method will allow for linkage of FDA's equivalence standards to in vivo performance.

This FOA is soliciting research projects that would advance biomedical research on the role of peripheral proteostasis on brain structure and function during aging and in Alzheimer's disease, facilitating the identification of molecular and cellular markers of normal brain aging and brain aging during pathological conditions.

This FOA invites exploratory comparative biology research projects assessing how different animal species respond to challenges and damage to cellular physiology pathways that might influence the onset of Alzheimer's and other neurodegenerative diseases as well as resilience to them, such as adaptation to stress, macromolecular damage, proteostasis and stem cell function and regeneration.    

The Biotechnology and Biochemical Engineering (BBE) program supports fundamental engineering research that advances the understanding of cellular andbiomolecular processes in engineering biology and eventually leads to the development of enabling technology for advanced manufacturing and/or applications in support of the biopharmaceutical, biotechnology, and bioenergy industries, or with applications in health or the environment. A quantitative treatment of biological and engineering problems of biological processes is considered vital to successful research projects in the BBE program. Fundamental to many research projects in this area is the understanding of how biomolecules, cells and cell populations interact in their environment, and how those molecular level interactions lead to changes in structure, function, phenotype, and/or behavior. The program encourages highly innovative and potentially transformative engineering research leading to novel bioprocessing and manufacturing approaches, and proposals that address emerging research areas and technologies that effectively integrate knowledge and practices from different disciplines while incorporating ongoing research into educational activities. 

The Engineered Living Materials (ELM) program will develop design tools and methods that enable the engineering of structural features into cellular systems that function as living materials, thereby opening up a new design space for building technology.

The Biotechnology and Biochemical Engineering (BBE) program supports fundamental engineering research that advances the understanding of cellular and biomolecular processes in engineering biology and eventually leads to the development of enabling technology for advanced manufacturing and/or applications in support of the biopharmaceutical, biotechnology, and bioenergy industries, or with applications in health or the environment.  A quantitative treatment of biological and engineering problems of biological processes is considered vital to successful research projects in the BBE program. 

The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function. The new tools and technologies should inform and/or exploit cell-type and/or circuit-level specificity. Plans for validating the utility of the tool/technology will be an essential feature of a successful application. The development of new genetic and non-genetic tools for delivering genes, proteins and chemicals to cells of interest or approaches that are expected to target specific cell types and/or circuits in the nervous system with greater precision and sensitivity than currently established methods are encouraged. Tools that can be used in a number of species/model organisms rather than those restricted to a single species are highly desired. Applications that provide approaches that break through existing technical barriers to substantially improve current capabilities are highly encouraged.