It was concluded that omega-3 fatty acid could inhibit the proliferation of pancreatic cancer cell line SW1990 cells and promote their apoptosis. The down-regulation of the cyclin E expression by omega-3 fatty acid might be one of the mechanisms for its anti-tumor effect on pancreatic cancer.
Modulatory effects of EPA and DHA on proliferation and apoptosis of pancreatic cancer cells.
Zhang W, Long Y, Zhang J, Wang C.
J Huazhong Univ Sci Technolog Med Sci. 2007 Oct;27(5):547-50.
PMID: 18060632
Omega-3 augmentation of sertraline in treatment of depression in patients with coronary heart disease: a randomized controlled trial.
Carney RM, Freedland KE, Rubin EH, Rich MW, Steinmeyer BC, Harris WS.
JAMA. 2009 Oct 21;302(15):1651-7.
PMID: 19843899
Conclusions Treatment of patients with CHD and major depression with sertraline and omega-3 fatty acids did not result in superior depression outcomes at 10 weeks, compared with sertraline and placebo. Whether higher doses of omega-3 or sertraline, a different ratio of EPA to DHA, longer treatment, or omega-3 monotherapy can improve depression in patients with CHD remains to be determined
Ethyl-eicosapentaenoic acid for the treatment of psychological distress and depressive symptoms in middle-aged women: a double-blind, placebo-controlled, randomized clinical trial.\nLucas M, Asselin G, Mérette C, Poulin MJ, Dodin S.\nAm J Clin Nutr. 2009 Feb;89(2):641-51. Epub 2008 Dec 30.\nPMID: 19116322 \ndoi:10.3945/ajcn.2008.26749
Dietary omega-3 polyunsaturated fatty acids plus vitamin E restore immunodeficiency and prolong survival for severely ill patients with generalized malignancy: a randomized control trial.
Gogos CA, Ginopoulos P, Salsa B, Apostolidou E, Zoumbos NC, Kalfarentzos F.
Cancer. 1998 Jan 15;82(2):395-402.
PMID: 9445198
DOI: 10.1002/(SICI)1097-0142(19980115)82:23.0.CO;2-1
Dietary supplementation with omega-3 PUFA (18 g/day) restored both the Th/Ts cell ratio and TNF production by endotoxin-stimulated PBMC. Our finding is not in accordance with former reports that long term consumption of omega-3 PUFA decreases T cell mitogenic response, DTH, and the percentage of T-helper cells,[28] and this may be the result of the parallel antioxidant effect of vit E. Most significantly, omega-3 PUFA increased the survival of all our patients, ...
Omega 3 fatty acids and the brain: review of studies in depression.
Sinclair AJ, Begg D, Mathai M, Weisinger RS.
Asia Pac J Clin Nutr. 2007;16 Suppl 1:391-7. Review.
PMID: 17392137
This paper discusses the clinical studies conducted in the area of depression and omega 3 PUFA and the possible mechanisms of action of these PUFA. It is clear from the literature that DHA is involved in a variety of processes in neural cells and that its role is far more complex than simply influencing cell membrane properties.
Dietary omega-3 polyunsaturated fatty acids plus vitamin E restore immunodeficiency and prolong survival for severely ill patients with generalized malignancy: a randomized control trial.
Gogos CA, Ginopoulos P, Salsa B, Apostolidou E, Zoumbos NC, Kalfarentzos F.
Cancer. 1998 Jan 15;82(2):395-402.
PMID: 9445198
Resolvin E2: identification and anti-inflammatory actions: pivotal role
of human 5-lipoxygenase in resolvin E series biosynthesis.
Tjonahen E, Oh SF, Siegelman J, Elangovan S, Percarpio KB, Hong S,
Arita M, Serhan CN.
Chem Biol. 2006 Nov;13(11):1193-202.
PMID: 17114001
doi:10.1016/j.chembiol.2006.09.011
Why fish oils may not always be adequate treatments for depression or other inflammatory illnesses: docosahexaenoic acid, an omega-3 polyunsaturated fatty acid, induces a Th-1-like immune response.
Maes M, Mihaylova I, Kubera M, Bosmans E.
Neuro Endocrinol Lett. 2007 Dec;28(6):875-80.
PMID: 18063921
Effect of glucosamine sulfate with or without omega-3 fatty acids in patients with osteoarthritis.
Gruenwald J, Petzold E, Busch R, Petzold HP, Graubaum HJ.
Adv Ther. 2009 Sep 4. [Epub ahead of print]
PMID: 19756416
DOI: 10.1007/s12325-009-0060-3