Berberine reduces the hypoxic-ischemic insult in rat pup brain.
Benaissa F, Mohseni-Rad H, Rahimi-Moghaddam P, Mahmoudian M.
Acta Physiol Hung. 2009 Jun;96(2):213-20.
PMID: 19457765
DOI: 10.1556/APhysiol.96.2009.2.6
Pathologic review of the samples obtained from rats treated with different doses of berberine in comparison with samples from pups treated by normal saline showed that there was a significant reduction of brain injury and edema in the rats treated with berberine. Our study also demonstrates that berberine reduces brain ischemic-hypoxic injury dose-dependently. Therefore, beberine may be considered as useful anti-stroke agent.