NEW YORK (Reuters Health) May 29 - Supplementation with coenzyme Q10 (CoQ10) improves endothelial dysfunction in patients with type 2 diabetes on statin therapy, according to results of a study reported in the May issue of Diabetes Care.
The vascular benefits of statins might be attenuated by inhibition of CoQ10 synthesis, Dr. Gerald T. Chew and colleagues from University of Western Australia, Perth, note in their report.
Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects.
Tarcin O, Yavuz DG, Ozben B, Telli A, Velioglu Ogunc A, Yuksel M, Toprak A, Yazici D, Sancak S, Deyneli O, Akalin S.
J Clin Endocrinol Metab. 2009 Jul 7. [Epub ahead of print]
PMID: 19584181
doi:10.1210/jc.2008-1212
Conclusions: This study shows that 25(OH)D deficiency is associated with endothelial dysfunction and increased lipid peroxidation. Replacement of vitamin D has favorable effects on endothelial function. Vitamin D deficiency can be seen as an independent risk factor of atherosclerosis. Hypovitaminosis D associated endothelial dysfunction may predispose to higher cardiovascular disease in the winter.
Oral administration of both tetrahydrobiopterin and L-arginine prevents endothelial dysfunction in rats with chronic renal failure.
Yamamizu K, Shinozaki K, Ayajiki K, Gemba M, Okamura T.
J Cardiovasc Pharmacol. 2007 Mar;49(3):131-9.
PMID: 17414224
doi: 10.1097/FJC.0b013e31802f9923