DHA and EPA generally modulated different sets of genes, although a few common effects were noted. In our approach, we used preneoplastic adenoma cells which are a relevant model for target cells of chemoprevention. If verified with real time PCR, these results identify genes and targets for chemoprevention of colon cancer.
Modulation of gene expression in eicosapentaenoic acid and docosahexaenoic acid treated human colon adenoma cells.
Habermann N, Lund EK, Pool-Zobel BL, Glei M.
Genes Nutr. 2009 Mar;4(1):73-6. Epub 2009 Feb 21.
PMID: 19234733
doi: 10.1007/s12263-009-0112-y.
The polyp prevention trial continued follow-up study: no effect of a low-fat, high-fiber, high-fruit, and -vegetable diet on adenoma recurrence eight years after randomization.
Lanza E, Yu B, Murphy G, Albert PS, Caan B, Marshall JR, Lance P, Paskett ED, Weissfeld J, Slattery M, Burt R, Iber F, Shike M, Kikendall JW, Brewer BK, Schatzkin A; Polyp Prevention Trial Study Group.
Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1745-52.
PubMed PMID: 17855692
doi: 10.1158/1055-9965.EPI-07-0127
his study failed to show any effect of a low-fat, high-fiber, high-fruit and -vegetable eating pattern on adenoma recurrence even with 8 years of follow-up.