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A negative regulator of MAP kinase causes depressive behavior : Nature Medicine : Natur... - 0 views

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    New findings in rodents and human brain shed light on the mechanisms of major depressive disorder (MDD), uncovering over-expression of MKP-1 (mitogen-activated protein kinase [MAPK] phosphatase-1)...and identifying a new therapeutic target. MKP-1, also known as dual-specificity phosphatase-1 (DUSP1), is a member of a family of proteins that dephosphorylate both threonine and tyrosine residues and thereby serves as a key negative regulator of the MAPK cascade4, a major signaling pathway involved in neuronal plasticity, function and survival This study identifies MKP-1 as a key factor in MDD pathophysiology, and as a new target for therapeutic interventions.f Here we use whole-genome expression profiling of postmortem tissue and show significantly increased expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1, encoded by DUSP1, but hereafter called MKP-1) in the hippocampal subfields of subjects with MDD compared to matched controls. MKP-1, also known as dual-specificity phosphatase-1 (DUSP1), is a member of a family of proteins that dephosphorylate both threonine and tyrosine residues and thereby serves as a key negative regulator of the MAPK cascade4, a major signaling pathway involved in neuronal plasticity, function and survival. We tested the role of altered MKP-1 expression in rat and mouse models of depression and found that increased hippocampal MKP-1 expression, as a result of stress or viral-mediated gene transfer, causes depressive behaviors. Conversely, chronic antidepressant treatment normalizes stress-induced MKP-1 expression and behavior, and mice lacking MKP-1 are resilient to stress. These postmortem and preclinical studies identify MKP-1 as a key factor in MDD pathophysiology and as a new target for therapeutic interventions.
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JAMA -- Abstract: Antidepressant Drug Effects and Depression Severity: A Patient-Level ... - 0 views

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    Antidepressants, despite their popularity, are no more effective than sugar pills for most people with mild or moderate depression. For severe depression, they're somewhat more effective, but far from a cure.
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JAMA Network | Archives of General Psychiatry | Dehydroepiandrosterone Monotherapy in M... - 0 views

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    "Dehydroepiandrosterone Monotherapy in Midlife-Onset Major and Minor Depression"
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Psychiatry Weekly: Treatment Options in Treatment-Resistant Depression - 0 views

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    Treatment Options in Treatment-Resistant Depression, by Jennifer Gotto, MD, and Mark H. Rapaport, MD
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Neurogenesis in the adult brain: The association with stress and depression || Bio-Medi... - 0 views

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    Professor Fuchs from the Clinical Neurobiology Laboratory, German Primate Center in Goettingen, will present the latest findings on how brain cells can be adversely affected by stress and depression. He will explain how the adult brain is generating new cells and which impact these findings will have on the development of novel antidepressant drugs. Contact: Sonja Mak s.mak@update.europe.at 43-140-55734 European College of Neuropsychopharmacology Source:Eurekalert (2008)
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PsychiatryOnline | APA Practice Guidelines | Guideline Watch: Practice Guideline for th... - 0 views

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    "The American Psychiatric Association (APA) practice guidelines are developed by expert work groups using an explicit methodology that includes rigorous review of available evidence, broad peer review of iterative drafts, and formal approval by the APA"
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DHEA - Will DHEA Improve Your Well Being and Sexuality - 0 views

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    "According to a small German study published in the New England Journal of Medicine (NEJM), researchers found that DHEA improved sexuality and well-being in 24 women diagnosed with adrenal insufficiency. The double-blind study found that women who took 50 mg of DHEA daily reported significant increases in how often they thought about sex, how interested they were in sexual activity, and their levels of both mental and physical sexual satisfaction. These women also reported improvement in mental health issues such as obsessive-compulsive traits, depression, anxiety, and other psychological conditions. The most significant improvements were seen four months after treatment began. "
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DHEA - What You Need to Know - 0 views

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    "There are very few large, well-designed human studies testing the health effects of DHEA supplements. For example, there is not enough scientific evidence to rate the effectiveness of DHEA supplements in treating adrenal insufficiency, metabolic syndrome, depression, HIV/AIDS, Addison's disease, chronic fatigue syndrome, menopausal symptoms, heart disease, breast cancer, infertility, diabetes, or Parkinson's disease according to the National Institutes of Health (NIH). In addition, there isn't enough evidence to support the use of DHEA supplements as an anti-aging remedy or weight-loss aid. The NIH also cautions that DHEA supplements appear to be ineffective for boosting libido, enhancing muscle strength in elderly people, protecting against Alzheimer's disease and improving thinking in healthy older people."
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Antidepressant Medicines - A Guide for Adults With Depression - AHRQ Effective Health C... - 0 views

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    Available forms: PDF, Download Audio, Listen to Audio Stream
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