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Sure, some of the world's best biomedical minds work in Toronto's MaRS Centre and hospitals.

Sure, some of the world's best biomedical minds work in Toronto's MaRS Centre and hospitals.

Sure, some of the world's best biomedical minds work in Toronto's MaRS Centre and hospitals.

Sure, some of the world's best biomedical minds work in Toronto's MaRS Centre and hospitals.

Sure, some of the world's best biomedical minds work in Toronto's MaRS Centre and hospitals.

Sure, some of the world's best biomedical minds work in Toronto's MaRS Centre and hospitals.

Sure, some of the world's best biomedical minds work in Toronto's MaRS Centre and hospitals.

The closest thing to a would-be Waterloo in Toronto is the medical "discovery district" around College Street and University Avenue, near the University of Toronto and several teaching hospitals. In the midst of it is

"There's an enthusiasm in the research community that's very exciting to be part of," says Dr. Keller, who now heads the McEwan Centre for Regenerative Medicine.

Dr. Hudson, who left Quebec to head the Ontario Institute for Cancer Research, says the city's "tremendous power" is built on a strong history: Stem-cell research began here. "It's innovative," he says of Toronto. "I've never felt closer in my research career to thinking we will have an impact. I feel my goals are going to happen here."

Still, John Evans, board chairman of the non-profit MaRS Centre, which helps to turn research into viable businesses, envisages a day when research is seen as a social and economic driver, and the city shines as brightly as better-known centres such as Boston and Palo Alto.

A key strategic focus of the SickKids Research Institute is the commercialization of research findings-translating discoveries into new technologies and treatments to improve the understanding and treatment of diseases that affect children.

"An environment like the Discovery District allows research institutes and the University of Toronto and its affiliated hospitals to work together to promote research and its application," she explains.

One of the unique aspects of Toronto is its open, collaborative environment. Individual institutes are not fighting each other for funding resources. This collaborative nature is what people comment on when they come here." A Toronto location provides other advantages too, she says. "There is a strong university and college environment, which provides a great pool from which to draw talent. There is strong support from all three levels of government. And there is strong philanthropic support, which is important." Dr. Rossant says working for the Hospital for Sick Children has been very gratifying.

Dr. Rossant is also looking forward to the opening of the new research and education building going up in the Discovery District. "The Research Institute currently has 2,000 people spread across the Discovery District and the new building will bring us all together and allow us to interact in new ways."

With support from the Mississauga Technology Business Accelerator (MTBA) he started his business, which grew to occupy some state-of-the-art labs at MaRS and is about to take the next step forward by moving its business outside of the protecting and nurturing environment of MaRS. This is the entire purpose of MaRS, which says on its website (www.marsdd.com), "We measure our success through the companies that emerge after receiving help from MaRS." "The resources, the facilities, the training and everything else that MaRS is bringing to the table - we're able to capitalize on that and get off on a very solid footing," says Kamal. Inside the Incubato

Whether you're looking for work - or you want to start your own business, MaRS is one of the best places to start your search.

Everybody you talk to in the elevator, the hall, the cafeteria - they are all in the science field - so you can network with one another," says Ratheesh. "MaRS does not just provide research space, they are bringing business people, people with money." These are the connections that can turn your idea into a profit-making business that employs many people. This is exactly what MaRS is all about. As they say on their website, "MaRS connects the communities of science, business and capital and fosters collaboration among them." MaRS advisors are able to connect entrepreneurs with private funding opportunities as well as free educational programming and hands-on advisory services. Corporate sponsor CIBC funds an entrepreneurship lecture series, for example. Ratheesh adds, "Patent people are here as well, so if you have patentable technology, you can talk to them." Once you start your business, MaRS offers many supports. "When we had the lab space we had the chemical hood that had to be set up so MaRS came and provided people to set up our hood," explains Ratheesh. "They help us dispose of chemical waste, provide water service, fridge and freezer service - so these are all important. "For smaller companies that have problem buying fridges and freezers, they can use common equipment." MaRS facilities also include lecture theatres, meeting rooms and an auditorium. Growing Cultures Bacteria and tissue cultures aren't the only cultures that thrive in the MaRS environment. It's also a great place for newcomers from every culture to

Clera, one of many emerging companies housed in the MaRS incubator.

He says, "MaRS is a one-stop shop for job and information seekers. Here we have many companies - so quite a few job opportunities

the country's most significant collection of scientific and medical researchers.

This week, a program called MaRS Innovation announced the appointment of its first full-time president, Raphael (Rafi) Hofstein, a Harvard-trained, Israeli biomedical wizard who wants to bring together companies, scientists and funding under one roof to create a special alchemy of science and shekels.

Since its inception, MaRS has focused on turning big ideas into commercial projects. The difference between the two entities is that pretty much anyone with an idea or discovery could come to MaRS for support, regardless of whether they had their “eureka” moment in a state-of-the-art research lab or in their garage. MaRS Innovation, a separate endeavour with its own board of directors, only works with researchers from its 14 partner institutions, which include some of the most prestigious universities and hospitals in Canada. The goal of that project is to do the kind of work those institutions would normally try to do in-house, but on a bigger scale and, the project's backers hope, with better results.

MaRS Innovation is very much in its infancy. Officially launched last June, the project is barely a year old, and the board of directors was only announced this February. It has secured about $25-million in funding over five years to be used for commercialization of projects.

Dr. Hofstein is giving himself two to three years to roll out a success story – be it the creation of a new small company founded on the back of a researcher's drug discovery and funded by a big pharmaceutical firm, or a new discovery that, packaged properly, attracts serious venture-capital money.

The federal government has also taken notice, naming MaRS Innovation as one of 11 new “Centres of Excellence for Commercialization and Research,” a designation that came with almost $15-million in funding.

California Governor Arnold Schwarzenegger speaks at MaRs with Premier Dalton McGuinty after a tour of the building in 2007.

Indeed, the MaRS Innovation model of pushing for commercial applications of research seems to be directly in line with the philosophy of the Conservative government, which clearly favours practical results when it comes to funding for scientific research.

But those tasks involve two separate skill sets, Mr. Tabrizi suggests, and may be much better suited to a place such as MaRS, where academic and industry heavyweights converge.

Many of MaRS's biggest partners are in health care, and Dr. Hofstein is jumping in with a list of priorities that includes focusing on stem-cell research and oncology.

MaRS itself has always been good at bringing people from various sectors together, but there's no guarantee that Dr. Hofstein's plan will work, especially in the two-to-three-year timeline he mentions when talking about a rollout date for the first MaRS Innovation projects.

Indeed, Mr. Tabrizi says some Silicon Valley insiders marvel at what MaRS Innovation is trying to do. “I think there's something innovative there,” he says. “Something different is being done.”

Tonight, in Toronto, Pawson will be honoured for his latest achievement: Winning the prestigious Kyoto Prize in Basic Sciences. He will share the podium with Charles Taylor, professor emeritus at McGill University, who won the prize in the Arts and Philosophy category. They are the first Canadians to win the coveted prize from the Inamori Foundation of Kyoto.