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Assunta Krehl

Pharmafocus.com - 0 views

  • Canada has always had to fight hard to attract talent and investment
  • MaRS Vital to Toronto's life sciences vision is MaRS (derived from Medical and Related Sciences) a non-profit organisation and business centre located in the heart of the city. Its core function is as a biotech incubator and business park, known as MaRS Discovery District. The venture was first established in 2000 to help foster and accelerate the growth of successful Canadian businesses and, after some uncertain times, it is now gathering momentum. A separate technology transfer office, MaRS Innovation, has also been established that, it is hoped, can be a world beater in its own right (see Turning good ideas into world beaters below). The location of the MaRS building in central Toronto is important, as it is just a stone's throw away from an existing cluster of universities and academic hospitals. MaRS has many links with other research-based organisations, including collaborations with three local universities, 10 academic teaching hospitals and the Ontario Institute for Cancer Research. MaRS occupies the Old Toronto general hospital, where insulin was first discovered by Best and Banting in 1921 and then developed for use in human trials. The 21st Century organisation can build on this heritage in patient-focused discovery and development. Formerly the head of venture capital firm Primaxis, Ilse Treurnicht is chief executive of MaRS Discovery District. She acknowledges the crisis in venture capital funding, and says Canada's sector has always had less access funds through this route than other countries. This is one of the drivers behind the search for a new approach. Treurnicht says the old models of building biotech and life sciences businesses have to be discarded, as they have failed to build companies with critical mass. She says MaRS' new 'Convergence Innovation' strategy of bringing science, capital and business together will pay off.
  • "We call our strategy 'Convergence Innovation' and what we are trying to do is move away from the old linear model of academics struggling in their spare time to build companies or entrepreneurs doing this in a very incremental way."It takes time and it has many risk points along the way. So using this Convergence centre model to create a much more dynamic organisation which can help accelerate good ideas towards the commercialisation." But she says Canada's geography and demographics are always going to be a challenge. "This is a very large country with a small population. If you think in terms of clusters and hub regions, Canada's business hubs are separated geographically, and there is not much in between in terms of people."That means we can't try to be a little United States, because we just won't show up on the radar. We have to take a different approach. We have to think about collaboration as our potential competitive advantage - that means using networks and associations to solve problems and build businesses."So as new opportunities emerge, we can take them to market faster and hopefully with a higher success rate." The centre currently accommodates numerous start up companies, as well as those providing legal and financial services to them. AstraZeneca and GlaxoSmithKline also have offices on site. In all, MaRS provides mentoring for over 200 different companies across Ontario, and runs courses on entrepreneurship and preparing products for market.
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  • Transition Therapeutics is one of the companies based at MaRS, and is an example of a biopharmaceutical company that is taking a new approach to the science and business of drug development.
  • Now Toronto's MaRS Innovation (MI) has been launched to try to guide and accelerate these promising ideas out of the wilderness and onto the market. MI is a not-for-profit technology transfer company that will channel all the best ideas to come out of Toronto's renowned academic centres. In the Toronto and Ontario area there were between 14-16 different technology transfer offices in the different institutions, and MaRS Innovation resolved to bring these interests together into a single entity after industry partners told them it was an inefficient way to do business. Bringing together the different institutions under one umbrella organisation has been an arduous task for MaRS, but the reward could be considerable for all parties. MI now oversees probably the largest intellectual property pipeline of its kind, representing about $1 billion in annual research spending. This means MI will be a unified route for all of Toronto's academics and their institutions when they want to develop and commercialise a bright idea. Most importantly, investors from industry who are looking to collaborate will now be able to deal with just organisation and one IP process. MI will cover patentable ideas across a broad range of areas, and not just life sciences - the discovery pipeline in physical sciences, information and communication technology, and green technology ('cleantech') will all be funnelled through MI. MI now represents three universities, 10 academic teaching hospitals and the Ontario Institute for Cancer Research. MaRS Innovation, with support from MaRS and BioDiscovery Toronto, will advance commercialisation through industry partnerships, licensing and company creation.
  • ts chief executive is Dr Rafi Hofstein. Hofstein has been headhunted from Israel where he was chief executive of Hadasit, the technology transfer company of the Hadassah Medical Organization in Jerusalem and chair of the publicly-traded company Hadasit BioHolding. He brings this considerable experience in technology transfer to what he thinks is a groundbreaking enterprise."MaRS Innovation is a unique global initiative, and I must commend the institutional leaders in Toronto for pulling this innovation powerhouse together to strengthen commercialisation output." He adds: "I believe this is going to modernise the whole notion of tech transfer." He says the scale and diversity of MaRS Innovation's remit puts it into a league of its own. Other research clusters elsewhere in the world have attempted similar projects before, but have been thwarted by the difficulty in bringing parties together. MaRS Innovation will also help launch and grow new spin-off companies and incubate them for 2-3 years to ensure a strong commercial footing. Hofstein says MI will also fund proof of concept trials which will persuade major pharma companies to invest in their development.
  • MI has just announced its first two commercialisation deals with academic partners in the city. The first is with the Samuel Lunenfeld Research Institute of Mount Sinai Hospital to develop stem cell from umbilical cords to treat cardiovascular disease, diabetes and neurological disorders. "With the Toronto area identified as a world-leading cluster in stem cell research, we are extremely excited to have identified this technology as our first commercialisation opportunity," said Dr Hofstein.
  • "Our partnership with MaRS Innovation on developing methods for using stem cells for diseases such as diabetes will allow us to work towards advancing care for these critical conditions."
  • The second collaboration is between MI and The University of Toronto (U of T) and involves a novel sustained release formulation of nitric oxide (NO) for applications in wound healing, including diabetic ulcers. "There are 300 million diabetics worldwide, of which some 15% develop troublesome foot ulcers. This wound healing technology is extremely exciting, making it an early commercialisation opportunity that MaRS Innovation has identified as being a potential win for some 45 million diabetics globally," said Dr Hofstein.
  • "This is one of many new commercialisation ventures that will be initiated by MaRS Innovation, our partner in commercialisation of research with 13 other academic institutions across the Greater Toronto Area," said Paul Young, U of T's vice-president, Research. "We at U of T are delighted that this innovation from Dr Lee will be taken to the marketplace to the benefit of society and the economy of Ontario and Canada." By aggregating the leading edge science of its institutional members and being a one-stop commercialisation centre for industry, entrepreneurs and investors, MI could really help put Toronto and Canada on the map."MaRS Innovation is deeply committed to facilitating strategic research collaborations with industry partners, strengthening the innovation capacity of Canadian industry through adoption of new technologies, and launching a new generation of robust, high-growth Canadian companies that will become global market leaders," added Dr Hofstein. "We look forward to working closely with all of our institutional members and to continue to jointly announce exciting commercial opportunities."
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    Canada has always had to fight hard to attract talent and investment. As stated in Pharmafocus.com, "MaRS Discovery District helps to foster and accelerate the growth of successful Canadian businesses." MaRS Innovation has also been launched to accelerate ideas onto the market.
Assunta Krehl

Dr. Calvin Stiller appointed Chair of Board of Directors - Ontario Institute for Cancer... - 0 views

  • The Board of Directors of the Ontario Institute for Cancer Research (OICR) has appointed Dr. Calvin Stiller as the Chair of the Board.
  • He succeeds Dr. John Evans, who was the first Chair and who will continue to serve as a board member.
  • Dr. Stiller co-founded the MaRS Centre in Toronto
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    The Board of Directors of the Ontario Institute for Cancer Research (OICR) has appointed Dr. Calvin Stiller as the Chair of the Board. Mention of Dr. Stiller Co-Founding MaRS.
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    The Board of Directors of the Ontario Institute for Cancer Research (OICR) has appointed Dr. Calvin Stiller as the Chair of the Board. Mention of Dr. Stiller Co-Founding MaRS. Jan 21, 2009
Assunta Krehl

Ontario Institute for Cancer Research - The Scientist - June 3, 2010 - 0 views

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    The Ontario Institute for Cancer Research (OICR) is a new center of excellence. It is moving Ontario to the forefront of discovery and innovation in cancer research
Assunta Krehl

Ontario Institute for Cancer Research Plans Hires, Increased Commercial Activities - Ge... - 0 views

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    The Ontario Institute for Cancer Research in 2010 will grow its workforce, step up efforts to commercialize discoveries, and aim to fulfill research goals to be detailed in a second strategic plan set to be submitted next month to provincial officials, according to the institute's president and scientific director, Tom Hudson.
Assunta Krehl

Cancer chief wins precursor to Nobel - National Post - April 7, 2010 - 0 views

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    Calvin Stiller, chairman of the Ontario Institute for Cancer Research, won the Canada Gairdner Wightman Award for his work on the use of cyclosporine as a treatment for organ transplant rejection, but also for his role as a scientific entrepreneur, and a rainmaker for major scientific projects. Dr. Calvin Stiller is the Chair of Ontario Institute for Cancer Research, Co-Founder and Board Member of MaRS Discovery District and past chair of Genome Canada.
Assunta Krehl

From `Eureka!' to real help for cancer patients - The Star - 0 views

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    Tom Hudson is announced as the President and Scientific Director of the Ontario Institute for Cancer Research (OICR).
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    Tom Hudson is announced as the President and Scientific Director of the Ontario Institute for Cancer Research (OICR). Nov 13, 2006
Assunta Krehl

MaRS research and innovation hub to expand: Phase two construction will create 4,000 di... - 1 views

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    MaRS Discovery District Phase II construction is now underway and scheduled for completion in September 2013. Public Health Ontario and Ontario Institute for Cancer Research will be the anchor tenants in the Phase II development.
Assunta Krehl

Three red cranes on Hospital Row signal a new future for MaRS construction - National P... - 0 views

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    MaRS Discovery District Phase II construction is now underway and scheduled for completion in September 2013. Public Health Ontario and Ontario Institute for Cancer Research will be the anchor tenants in the Phase II development.
Assunta Krehl

OICR invests $1 million in the further development of two new cancer treatments - Canad... - 0 views

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    Dr. Tom Hudson, President and Scientific Director of the Ontario Institute for Cancer Research (OICR) announced an investment of $1 million towards the development of two new promising cancer therapies. OncoTek Drug Delivery Inc (a subsidiary of Receptor Therapeutics) is one of the recipients.
Assunta Krehl

Diamond Schmitt Architects to design cancer research lab space at MaRS in Toronto - Dai... - 0 views

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    "Diamond Schmitt Architects will design research laboratory space for the Ontario Institute for Cancer Research (OICR) at the MaRS Phase II west tower currently under construction in downtown Toronto." MaRS Phase II occupancy is slatted for 2013.
Assunta Krehl

Science City - The Globe and Mail - 0 views

  • This is Toronto's research district, a maze of concrete and glass where the finest minds collaborate, turning the city into a global centre of biomedical discovery.
  • Nine research institutes employing 5,000 university faculty members, 2,000 graduate students and 1,100 postdoctoral and clinical fellows lie within a 20-minute walk of each other. This biomedical cluster at the heart of Toronto is one of the largest on the continent, and is one of the 10 largest in the world.
  • Tom Hudson from Montreal; cell biologist Ben Neel from Boston; and stem-cell biologist Gordon Keller, who came to Toronto in 2006, just months after New York magazine named him one of the scientists that city could not afford to lose. Toronto is also home to Tak Mak, who discovered the "key to the immune system" T-cell receptor, and John Dick, who discovered the first cancer stem cell in 1994 and last year grew a human cancer in a lab mouse for the first time.
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  • "There's an enthusiasm in the research community that's very exciting to be part of," says Dr. Keller, who now heads the McEwan Centre for Regenerative Medicine.
  • Dr. Hudson, who left Quebec to head the Ontario Institute for Cancer Research, says the city's "tremendous power" is built on a strong history: Stem-cell research began here. "It's innovative," he says of Toronto. "I've never felt closer in my research career to thinking we will have an impact. I feel my goals are going to happen here."
  • Still, John Evans, board chairman of the non-profit MaRS Centre, which helps to turn research into viable businesses, envisages a day when research is seen as a social and economic driver, and the city shines as brightly as better-known centres such as Boston and Palo Alto.
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    Tenille Bonoguore, Globe and Mail features the MaRS Centre and meets 12 of its' "best specimens." MaRS is one of the 10 largest biomedical clusters in the continent.
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    Tenille Bonoguore, Globe and Mail features the MaRS Centre and meets 12 of its' "best specimens." Bonoguore states "MaRS Centre is one of the 10 largest biomedical clusters in the continent." Jan 5, 2008
Assunta Krehl

Building a Successful Biotech Incubator - 0 views

  • MaRS aggregates the discovery pipelines of its member institutions, which include three universities, 10 academic teaching hospitals, and the Ontario Institute for Cancer Research.
  • MaRS is another good example. Located in the heart of downtown Toronto, the MaRS facility is less than a mile from five major teaching hospitals, the Ontario legislature, and the University of Toronto. More than two dozen research institutes and Toronto’s financial district are also nearby.
  • Consequently, MaRS is a vertical incubator, with a wide variety of companies and stages of development. That mix helps companies better understand the conditions that foster growth. MaRS is home to more than 65 organizations, including The Hospital for Sick Children, the Ontario Institute for Cancer Research, Merck Frosst Canada, the McEwen Centre for Regenerative Medicine, Celtic House Venture Partners, AIM Therapeutics, and AstraZeneca Canada.
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  • “Collaboration is the essence of the new economy,” insists Ross Wallace, director of strategic partnerships at MaRS. “There’s a new focus on the power of institutions to generate intellectual property and ideas, and then build around them.”
  • MaRS has a virtual education program dubbed “Entrepreneurship 101.” One February class features budgeting, another agrifood innovation. The classes are available at no cost, and anyone can register. The program also includes blogs and discussion groups such as the drug development and cancer targets groups. So far, MaRS has relied on viral marketing to get the word out.
  • To provide that expertise, MaRS developed the MaRS Venture Group. This team of experienced investors, entrepreneurs, technology experts, and advisors works with companies to help them bridge the gap between entrepreneurial start-up and experienced growth company. The Venture Group provides market intelligence as well  as advisory services such as strategic planning, partnership and alliance building, intellectual property management, marketing and communications, sales strategy, channel development, financing, and human resource development. It works with groups outside the MaRS orbit, too.
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    To have a successful biotech initiative proximity to academic hubs and capital remains a crucial factor in hatching a thriving cluster. MaRS Discovery District is a good example of a vertical incubator and offers many services to help entrepreneurs at different stages.
Assunta Krehl

The New Face of Cancer - The Scientist - June 2, 2010 - 0 views

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    The Ontario Institute for Cancer Research (OICR) is applying the newest concepts in life sciences-stem cell therapies, personalized medicine-to one of the oldest diseases.
Assunta Krehl

Lab Canada - * Printer friendly version * Email story to a friend * Send ... - 0 views

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    To improve early detection and treatment of cancer, a pair of Toronto scientists, Dr David Jaffray, a senior scientist in the division of biophysics and bioimaging at the Ontario Cancer Institute and Dr Christine Allen, an associate professor in the Leslie Dan Faculty of Pharmacy at the University of Toronto has developed a technology that combines contrast agents with targeted, long-lasting nano-particles for use in multiple medical imaging platforms. MaRS Innovation (MI) and the University Health Network (UHN) have now entered into an agreement to collaboratively commercialize this promising technology. Dec 23, 2009
Assunta Krehl

McGuinty and Schwarzenegger team up to boost stem cell research - BioscienceWorld - 0 views

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    McGuinty and Schwarzenegger team signed a new $30M joint research venture to develop new stem cell therapies to help conquer cancer. The new Cancer Stem Cell Consortium will be headquartered at the MaRS Centre.
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    McGuinty and Schwarzenegger team signed a new $30M joint research venture to develop new stem cell therapies to help conquer cancer. The new Cancer Stem Cell Consortium will be headquartered at the MaRS Centre. Jun 1, 2007
Assunta Krehl

MaRS Innovation appoints president and CEO - University of Toronto -- News@UofT - 0 views

  • MaRS Innovation appoints president and CEO
  • A research commercialization leader from Israel, Dr. Raphael Hofstein, has been named president and CEO of the new MaRS Innovation initiative.
  • MI was created as a single, market-facing commercialization storefront for Toronto's university and health research institutions. Located in the MaRS Discovery District complex, with business development and administrative support from MaRS, MI will advance commercialization through industry partnerships, licensing and company creation. MaRS Innovation (MI) was founded in 2008 with $14.95 million in funding from the Government of Canada's Centres of Excellence for Commercialization and Research (CECR) Programme, matched by $10 million from the research partners. The MI partnership includes U of T, the 10 partner hospitals and health research institutes affiliated with the university, Ryerson University, the Ontario College of Art & Design, BioDisocovery Toronto, the Ontario Institute for Cancer Research and MaRS. Hofstein joins MaRS Innovation from his previous position as president and CEO of Hadasit Ltd., the technology transfer company of the Hadassah Medical Organization in Jerusalem.
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  • "MaRS Innovation is a unique global initiative, and I must commend the institutional leaders in Toronto for pulling this innovation powerhouse together to strengthen commercialization output. In my experience, good science is the single most important ingredient for success in this business. Toronto is already known as one of the strongest science cities in the world, and it continues to grow. Leading MaRS Innovation is a wonderful opportunity to do something remarkable."
  • Dr. Tim McTiernan, assistant vice-president (research) and executive director of The Innovations Group (TIG), U of T's research commercialization operation, said Mars Innovation will provide significant benefits to U of T.
  • And he said that MI's role as a resource "is like putting a turbo charger on an engine. Having MI working with us and the other member organizations is a huge step in taking advantage of the enormous potential in the Toronto research community. Commercialization offices acting independently will not be able to manage in nearly as effective a manner as will be possible with the expertise of MaRS Innovation."
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    Dr. Raphael Hofstein named president and CEO of the new MaRS Innovation initiative.
Assunta Krehl

Toronto's $25 million commercialization "engine" celebrates the appointment of its Boar... - 0 views

  • MaRS Innovation is honoured to announce its permanent Board of Directors, who brings together a remarkable and broad set of experiences and networks to support the development of this dynamic partnership of Toronto research institutions.  Designed to enhance the commercial output of Toronto’s world-leading research cluster, MaRS Innovation is positioned to make a significant contribution to Canada’s innovation economy and the quality of life for Canadians and others around the world.
  • upported by the Government of Canada through the Centres of Excellence in Research and Commercialization (CECR) program, and its member institutions, MaRS Innovation is focused on converting important discoveries into a new generation of products, services and high value jobs. The newly appointed Board of Directors, which includes academic and business leaders from across Canada and the United States, has the targeted expertise to guide MaRS Innovation to deliver on this critical mission.   MaRS Innovation represents a unique collaborative model, which aggregates the exceptional discovery pipeline of 14 leading Toronto academic institutions to build a diversified portfolio of assets, and harness the economic and job creation potential of the best opportunities for Toronto, Ontario and Canada.
  • “MaRS Innovation is privileged to announce a Board of Directors of this caliber and breadth of skill,” said Mary Jo Haddad, Chair of the MaRS Innovation Board and President and CEO of The Hospital for Sick Children. “The collective experience and guidance of these individuals will be critical to developing a collaborative, integrated and agile approach to this transformational organization that will move Canada into its next phase of economic development.”
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  • W. Geoffrey Beattie – Deputy Chairman & President, Woodbridge Company Limited, Thomson Reuters Corporation, Toronto Christopher C. Capelli – Vice President, Technology Based Ventures, Office of Technology Commercialization, University of Texas, M.D. Anderson Cancer Center, Houston, TX Ron Close – Information technology entrepreneur, Entrepreneur-in-Residence, MaRS, and Executive Entrepreneur-in-Residence, The Richard Ivey School of Business, The University of Western Ontario, London, ON Nicholas Darby – Formerly Director of Physical Sciences, Corporate Venture Capital, Dow Chemical Company, President, Darby & Associates Consulting LLC, Midland, MI  Mary Jo Haddad – President & CEO, The Hospital for Sick Children, Toronto Jacqueline H.R. Le Saux – Former General Counsel, North America and Corporate Secretary, Patheon, Inc., Toronto David A. Leslie - Chair, Sunnybrook Health Sciences Centre, and Former Chairman & CEO, Ernst & Young, Toronto Michael H. May – President & CEO, Rimon Therapeutics, Toronto Chandra J. Panchal – Founder, President & CEO, Axcelon Biopolymers Corp., Dollard-des-Ormeaux, QC Ilse Treurnicht – CEO, MaRS Discovery District, Toronto Donald A. Wright – President & CEO, The Winnington Capital Group Inc., Toronto
  • MaRS Innovation serves as a business accelerator platform with a single point of entry for industry partners and investors.  It will increase the scale, scope and viability of IP offerings, and the quantity and quality of deal flow from partner institutions.  MaRS Innovation will also facilitate strategic research collaborations with industry partners, strengthen the innovation capacity of Canadian industry through adoption of new technologies from its member institutions, and launch a new generation of robust, high-growth Canadian companies that will become global market leaders.   The quality of the combined discovery pipeline will catalyze and attract sources of risk capital for translational research, market validation, company formation and growth.  “MaRS Innovation represents a unique and timely platform to contribute in a meaningful way to Canada’s knowledge economy, leveraging Toronto’s remarkable research excellence.  The vision and serious commitment of its members to work together to transform our commercialization results, and the support of the Federal Government, made this possible.  The announcement of this outstanding group of leaders to the Board of Directors for MaRS Innovation is an exciting step forward,” said Ilse Treurnicht, MaRS CEO and interim Managing Director of MaRS Innovation.
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    MaRS Innovation announced its permanent Board of Directors. MaRS Innovation is focused on converting important discoveries into a new generation of products, services and high value jobs.
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    MaRS Innovation announced its permanent Board of Directors. MaRS Innovation is focused on converting important discoveries into a new generation of products, services and high value jobs. Feb 6, 2009
Assunta Krehl

CBC News - Winners of Gairdner medical prize unveiled - April 6, 2010 - 0 views

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    The 2010 Canada Gairdner Awards honour groundbreaking medical research behind cancer, epilepsy and heart disease and malaria treatments. Dr. Calvin Stiller, Chair of Ontario Institute for Cancer Research, Co-Founder and Board Member of MaRS Discovery District and past chair of Genome Canada is a recipient for the 2010 Canada Gairdner Award.
Assunta Krehl

Canada's Gairdner Foundation announces 2010 winners - The Star - April 6, 2010 - 0 views

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    The 2010 Canada Gairdner Awards honour groundbreaking medical research behind cancer, epilepsy and heart disease and malaria treatments. Dr. Calvin Stiller, Chair of Ontario Institute for Cancer Research, Co-Founder and Board Member of MaRS Discovery District and past chair of Genome Canada is a recipient for the 2010 Canada Gairdner Award.
Assunta Krehl

Medical research innovator gets double honour - The Globe and Mail - April 7, 2010 - 0 views

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    MD-entrepreneur Cal Stiller, noted for advocating commercial development of research, wins Gairdner Award and hall of fame berth. Dr. Calvin Stiller is the Chair of Ontario Institute for Cancer Research, Co-Founder and Board Member of MaRS Discovery District and past chair of Genome Canada.
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