Things We Don't Know: The beast with a billion backs: Part 2 - 0 views
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Whilst we can’t yet manipulate the microbiome with any finesse, we do influence it through our immune system, evolved over time to cope with invading pathogens and keep them in check.
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Two different species of bacteria with disks soaked in different antibiotics. The bacteria on the left are susceptible to all the antibiotics tested, while the bacteria on the right are resistant to most of them.
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If the immune system was a sniper, antibiotics would be a bomb, they don’t discriminate between targets.
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they broadly target bacterial cellular processes, like cell wall building, protein synthesis or metabolism.
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But their use throws up a number of questions in the light of our growing awareness of the microbiomes importance. How does the microbiome, as a whole, weather such attacks? How does it recover? And why should we even care?
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Well, we know that antibiotic use in early life is associated with a greater risk of developing allergic conditions like asthma1 and irritable bowel disorders2 (IBS) in later life, which is a pretty good reason to care on its own.
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There’s a growing body of evidence suggesting we rely on the microbiome3, to some extent, to tutor our immune systems.
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Another problem is that your microbiome’s response to antibiotics may be quite different to mine, and at the moment we can’t predict how much.
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The microbiomes of different people vary5, there’s no standard ‘set’, so while many groups of bugs share similar biochemical functions and niches, how they respond to antibiotics may differ considerably.
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There is a concept in ecology which is useful to illustrate this: keystone species6. Removing a keystone species can create a domino effect where other species that relied on it will disappear, allowing only a few remainder species to dominate, or new species to invade.
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The problem is how, out of so many different species in a microbiome, do we identify a keystone species? Can we predict which ones may survive, and which will perish under a given antibiotic?
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There’s good reason to believe antibiotics change the microbiome permanently, and consequentially impact our health.
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"No matter how quietly you listen, nor how closely you stare you'll not hear them, nor see them with the naked eye. They're too small, too quiet. They are our microbiome, the trillions of microorganisms that make their homes inside and out of our bodies. They - we - are an ecosystem, with different bugs filling different niches, some helpful, some quietly parasitic, and others, well, others you do end up knowing about…"