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katherine-medina

Sci-Hub | Antimicrobial activity of pomegranate fruit constituents against dr... - 0 views

sci-hub.se/...25858784

polyphenol bacteria-killing biochemistry HSR2023 pomegranate-seed

shared by katherine-medina on 06 Jul 23 - No Cached
    • katherine-medina
      katherine-medina on 06 Jul 23
       
      The peel extracts exhibited greater antimycobacterial activity (MIC 64-1024 mg/mL) than the potable juice (MIC 256 -41024 mg/mL). Cool an early answer,
    • katherine-medina
      katherine-medina on 06 Jul 23
       
      "exhibited estrogen-like activity" Why does it act like that, and that is crazy.
    • katherine-medina
      katherine-medina on 06 Jul 23
       
      I think that the Hodge tests will be something important for me to look into as I go further and further down the road of polyphenolic study.
  • katherine-medina on 06 Jul 23
     
    An interesting article that basically shows that pomegranate polyphenols can kill bacteria.
katherine-medina

https://assets.researchsquare.com/files/rs-2962278/v1/95a4813e-7c91-423d-8608-d3e697f79... - 0 views

assets.researchsquare.com/...c91-423d-8608-d3e697f797f4.pdf

MRSA stilbene polyphenols antibiotics HSR-2023 Research-idea pigeon-peas

shared by katherine-medina on 27 Jun 23 - No Cached
    • katherine-medina
      katherine-medina on 27 Jun 23
       
      A. Besides, the results implied that these stilbenes effectively inhibited the levels of adhesion and virulence genes and downregulate the production of -hemolysin. This study showed that stilbenes from pigeon pea have anti-Staphylococcus potential, and they also inhibited bacterial proliferation, biofilm formation, and key gene expressions related to adhesion and virulence of MRSA.
    • katherine-medina
      katherine-medina on 27 Jun 23
       
      "Over the past few years, bacterial biofilm has aroused wide attention. And the biofilm can be called sessile microbial community where cells are attached to the surface or to other cells and can embed themselves in a protective extracellular polymeric matrix." This is a pretty interesting piece of information.
    • katherine-medina
      katherine-medina on 27 Jun 23
       
      Moreover, as an ethnological herb, pigeon pea is adopted in traditional medicine for its treatments of diabetes (Al-Saeedi and Hossain 2015; Talukdar 2013), hepatic-disorder (Ghosh et al. 2006), necrosis of femoral head (Luo et al. 2009), measles (Nwodo Page 4/20 et al. 2011) and osteoporosis HUH that is really interesting considering the amount of pigeon peas I have had in arroz con gondules.
  • ...3 more annotations...
    • katherine-medina
      katherine-medina on 27 Jun 23
       
      The growth cures suggested that 1 MIC and 1/2 MIC of these compounds had remarkable inhibitory effects on the MRSA growth. Wow
    • katherine-medina
      katherine-medina on 27 Jun 23
       
      Additionally, the epidermis was the external barrier of the body and thus HaCaT (human keratinocyte) was used to investigate the cytotoxicity of these stilbenes. As a result, these compounds had no discernible harmful effects on HaCaT at concentrations of 1/4 of their MIC, and their IC50 on HaCaT were 9.58 ± 0.22, 12.76 ± 0.31, 18.38 ± 0.41 µg/mL, respectively. Hence, the maximum concentrations of these stilbenes were set at 1/4 MIC in the follow-up research It is quite remarkable that pigeon peas are that effective.
    • katherine-medina
      katherine-medina on 27 Jun 23
       
      It is incredibly important that the article states this, "However, current researches barely reveal the anti-MRSA biofilm ability of stilbenes from pigeon pea." This makes me want to learn more and more about how pigeon pea polyphenols work mostly because it is a very unexplored area of biochemistry.
  • katherine-medina on 27 Jun 23
     
    This article is about three different stilbenes in pigeon peas that were found to fight against MRSA.
Sean Nash

Microwaving an insecticide restores its mosquito-killing power - 2 views

www.sciencenews.org/...to-microwave-insecticide-spray

deltamethrin pesticide mosquito insecticide DDT crystals crystalline structure biochemistry environment evolution ecology chemistry heat potential research idea biology engineering environmental science HSR HSR-2023 HSR-2025

shared by Sean Nash on 25 May 23 - No Cached
  • Heating an insecticide can give it new life.
    • Sean Nash
      Sean Nash on 25 May 23
       
      Wait, what? Do say more.....
  • Microwaving the insecticide deltamethrin rearranges its crystal structure but doesn’t change its chemical composition. The rearrangement renews deltamethrin’s ability to kill mosquitoes that have become resistant to the insecticide, researchers report April 21 in Malaria Journal.
    • Sean Nash
      Sean Nash on 25 May 23
       
      Hmmmm... something similar to this smells like: feasibility.
  • The microwave worked just as well, but Kahr cautions that people shouldn’t use the same microwave for heating food and insecticides.
    • Sean Nash
      Sean Nash on 25 May 23
       
      Ha! No kidding??
  • ...6 more annotations...
  • insecticide resistance is a growing problem
  • It is encouraging that heated insecticide killed highly resistant mosquitoes, says Hemingway, who directs the Infection Innovation Consortium, a public-private effort to find new ways to combat infectious diseases. But, she says, “this is not something we can take and use that tomorrow.”
    • Sean Nash
      Sean Nash on 25 May 23
       
      OK.... this is how you can find an opening (not saying THIS ONE is necessarily, but, when you see language like: "we can't really do it just yet," that is a screaming opportunity to see what we MIGHT be able to add to that.
  • It’s not certain that the heat-treated deltamethrin would retain its more potent crystal structure through the net-making process.
  • Kahr’s team is working on incorporating the heat-treated crystal into nets.
  • “There are all kinds of social and cultural things that you could propose from a scientific perspective that wouldn’t be welcomed by a community of homeowners.”
    • Sean Nash
      Sean Nash on 25 May 23
       
      Again... this reads: "potential research opportunity."
  • Kahr and colleagues previously discovered that heating deltamethrin changed its crystal structure, which let it work faster
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