Group items tagged

WHAT IS PROTEINASE K MADE OF? Proteinase K is known enzyme belonging to the class of serine proteases that cleave adjacent to the carboxylic group peptide bonds of aromatic and aliphatic amino acids. It's also exhibited a very broad cleavage specificity. The enzyme was discovered in extracts of the fungus Engyodontium album. HOW DOES PROTEINASE K WORK? In molecular biology, main application of proteinase K is to digest proteins during nucleic acids purification in order to remove protein contaminants: - Proteinase K quickly inactivates nucleases (enzymes that digest nucleic acids) that degrade DNA or RNA molecules during the cleansing. - Proteinase K is activated by calcium. It does not affect the activity of the proteinase, but protects again autolysis, improves thermal stability, and regulates substrate binding capacity. To increase the stability of Proteinase K, thereby enhancing its action, Urea as well as SDS (sodium dodecyl sulfate) or elevated temperature at 37-60C is commonly used. Inactivation of Proteinase K is occurring at temperature above 65C. WHAT IS THE PURPOSE OF PROTEINASES? Proteinase K is used to break down proteins in cell lysates (tissues, cell culture cells) and to release nucleic acids due to its action described above. Proteinase K application purpose: DNA isolation from various tissues; Removal of DNAses and RNAses: Proteinase K and RNases can act together in the lysis buffer to degrades contaminating RNAs and proteins;

The Medicines and Healthcare products Regulatory Agency (MHRA) has authorised a new drug today (1 November) to treat severe alopecia areata. Litfulo is the new hard capsule medicine with a recommended dosage of just 50 mg per day. It contains an active ingredient, ritlecitinib, an enzyme inhibitor treatment for patients over 12 years. Ritlecitinib works by reducing the activity of enzymes in the body called JAK3 and TEC kinases that cause hair follicle inflammation. This reduction in inflammation leads to hair regrowth in patients with alopecia areata. Alopecia areata is an autoimmune disease, where the body's own immune system attacks hair follicles leading to hair loss on the scalp and other parts of the body.

Ubiquitination is a post-translational modification where ubiquitin is attached to a substrate protein. This process is carried out in three main steps, activation, conjugation and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s) respectively. The ubiquitin modification has three general layouts, monoubiquitination, multi-monoubiquitination and polyubiquitination (homotypic or heterotypic). The ubiquitination bonds are always formed with one of the seven lysine residues from the ubiquitin molecule. In a few rare cases nonlysine residues have been identified as ubiquitination targets, such as cysteine, threonine and serine. Ubiquitination can affect proteins in many ways. It can signal for their degradation via the proteasome, alter their cellular location, affect their activity, and promote or prevent protein interactions.

GSH has multiple functions in vivo. In the first place, GSH plays an important role in the biochemical defense system of human body and possesses many physiological functions. The main physiological function is that it can clear the free radicals in human body. And as a kind of important antioxidants in the body, it is used to protect mercapto in proteins and enzymes. Second, GSH can enhance human immunity and it has the functions of maintaining health and anti-aging. Third, GSH can protect hemoglobin (HGB) from oxidization of hydrogen peroxide and free radicals, which guarantees HGB to work normally and continually in oxygen transport. Fourth, GSH protects -SH group in enzymes, this can make for the full play of enzyme activities. GSH also can inhabit fatty liver caused by alcohol. Finally, for the hypoleucocytosis caused by radioactive rays and radiopharmaceutical, GSH provides a strong protection. It can combine with toxic compounds, heavy metal ions (HMI) or carcinogenic substance and contribute to eliminate from the body and have the effect of neutralization detoxification in the end.

Do you want to get rid of your scars? Studies have shown that serrapeptase is a miracle enzyme found in silkworms. It is best known for its effectivity on the removal of scar tissues. In this Whole Family Products blog, you will understand the miracle works of serrapeptase in scar tissue removal. Read it here.

The Medicines and Healthcare products Regulatory Agency (MHRA) has reclassified codeine linctus, a medicine used for the treatment of dry cough, from a pharmacy-only medicine (P) to a prescription-only medicine (POM) owing to the risk of dependence, addiction, and overdose. This implies that the dry cough syrup, which is also known as codeine oral solution, can only be dispensed upon the submission of a prescription at a pharmacy, rather than being accessible over the counter upon request. Patients are cautioned that as an opioid medicine, codeine can be addictive, and the risk of addiction may increase, particularly with prolonged use over an extended period. According to the medicines regulator, codeine is converted into morphine by the liver enzyme CYP2D6. In individuals identified as ultra-rapid metabolizers, this conversion from codeine to morphine occurs at a faster rate than in others. "If you want to stop taking it and have been taking codeine linctus for a long time, then it is important to reduce the amount you take slowly with the help of your prescriber," the agency said in its drug safety update issued on Tuesday, 20 February.

The joint supplement Cosamin DS is claimed to be the #1 Orthopedic recommended brand in this category. Nutramax Labs is the manufacturing company behind this product and it's very popular online as well as offline. Ingredients in Cosamin DS are enzymes for degrading cartilage, Glucosamine Hydrochloride which stimulates production of cartilage and Chondroitin Sulfate that inhibits cartilage break down.

In order to enable the immune system to function normally, the body needs: protein necessary for the construction of the immune cells and antibodies, carbohydrates for energy, which without any physiological process in the body is not possible, is also necessary for the fat metabolism, minerals and vitamins included in the composition of enzymes, which are due to perform and provide conversion processes. - See more at: http://www.immunesystemboosters.info/2013/08/which-vitamins-mostly-boost-immune.html#sthash.HRijemgv.dpuf

Apricot kernels contain glycosides (a combination of sugar and cyanide. In addition, apricots have a selective toxicity - a selective enzyme that's produced in large quantities by cancer cells and it triggers the breakdown of sugar that expels cyanide (kills the cancer cells

Palbace 125 Mg Capsules Suppliers-exporters India , Palbace a 125Mg Capsule is employed within the treatment of carcinoma. It's additionally wont to treat patients with bound varieties of carcinoma (estrogen receptor-positive, human stratum protein receptor 2-negative) that have unfold to alternative organs. it's given in conjunction with secretion malignant tumor therapies. We are leading suppliers & exporters of "Palbace 125Mg" in China, Russia, Hongkong, Bulgaria, Romania, India. We're largest suppliers of Pfizer India medicines & provide you the best price on Palbace 125Mg. The lowest price sellers, suppliers, distributors & Exporters from Delhi. For more info please contact us. Buy Online Palbace 125Mg Suppliers Price India Palbace 125Mg suppliers India Palbace 125mg Capsules Palbace (known as IBRANCE in other parts of the world) or palbociclib by Pfizer is a cancer drug that interferes with the growth and spread of cancer cells in the body. Description Brand Name: Palbace Generic Name: Palbociclib Strength: 125mg Packing: 21 Capsules in a bottle Form: Tablets Palbace125Mg is generally used in combination with letrozole or fulvestrant (Faslodex) for treating certain types of advanced breast cancer in postmenopausal women. It is also given in combination with another cancer medicine, either letrozole (Femara) or fulvestrant (Faslodex). Palbace is a renamed version of the drug Ibrance for the Indian market. It is verified by the US Food and Drug Administration (FDA). In clinical studies, palbociclib appeared to increase survival time of patients. Palbace comes in capsule form in 125 mg dose. 1 pack has 21 capsules. How Palbace125Mg capsules works ? Palbace 125mg capsule is an anti-cancer medication. It works by busy bodied with a enzyme, a sort of supermolecule within the body that helps management biological process. This stops cancer cells from dividing and growing. It is additionally won't to treat patients with bound kinds of carc

Presently, In the US, around 12% of women develop breast cancer over the course of their lifetime. In Canada, an estimated 26,900 women were expected to be diagnosed with breast cancer in 2019 and breast cancer accounts for nearly 25% of new cases of cancer among Canadian women. Download complete report summary @ http://bit.ly/2vsEa1D

Nitric Oxide plays an important role in strengthening the enzymes that might be responsible for our better health especially regarding the work-outs and other hardcore physical activities. In this Whole Family Products blog, you will learn the best nitric oxide supplements to be included in your diet. Read here.

In a significant leap forward in the fight against HIV, the Medicines and Healthcare products Regulatory Agency (MHRA) has given the green light to two groundbreaking formulations of cabotegravir. Apretude 30 mg film-coated tablets and Apretude 600 mg prolonged-release suspension for injection are now authorized for preventing sexually transmitted HIV-1 infection in adults and adolescents weighing at least 35kg at increased risk. This approval marks a pivotal moment in HIV (human immunodeficiency virus) prevention, offering an alternative to existing standard pre-exposure prophylaxis or PrEP treatments. HIV, a virus notorious for compromising the immune system, has long been a global health concern. Cabotegravir, a member of the integrase inhibitor group, works by blocking a key enzyme necessary for the replication of HIV-1, thereby reducing the virus's ability to spread.

Your gut, often referred to as your "second brain," plays a crucial role in your overall health and well-being. From digestion to immunity, mood regulation to nutrient absorption, the gut impacts various aspects of our daily lives. With increasing awareness of the gut-brain connection, prioritizing gut health has become a cornerstone of holistic wellness. In this article, we explore effective strategies to support and nurture your gut, empowering you to enhance your quality of life through simple yet impactful practices. Nourish with Probiotic-Rich Foods The gut microbiome, comprised of trillions of bacteria, fungi, and other microorganisms, is a dynamic ecosystem essential for digestive health and immune function. To maintain a healthy balance of gut flora, incorporating probiotic-rich foods into your diet is paramount. Yogurt, kefir, kimchi, sauerkraut, and kombucha are excellent sources of beneficial bacteria that promote gut diversity and resilience. These fermented foods not only replenish your gut with probiotics but also provide essential nutrients and enzymes vital for optimal digestion. By regularly including probiotic foods in your meals, you can foster a thriving gut microbiome, fortifying your body's natural defenses against pathogens and inflammation.

Accord Healthcare UK Ltd has announced that Disulfiram, an alcohol deterrent compound, will be made available to all UK pharmacists and dispensing doctors for prescription to suitable patients. Following its launch to wholesalers in December 2024, the medication will now be accessible for the treatment of alcohol dependence under appropriate medical supervision. Disulfiram is indicated as an adjuvant in the treatment of carefully selected and co-operative patients with drinking problems. The medication works by inhibiting the enzyme responsible for breaking down acetaldehyde-a substance produced when alcohol is metabolised in the body. This results in a buildup of acetaldehyde in the blood, triggering unpleasant reactions such as headaches, heart palpitations, and nausea. The experience of such reactions acts as a deterrent to further alcohol intake.

A new sense a hope rises from Washington. Researchers have finally come up with a significant discovery that could probably lead us to a way for a new treatment for Parkinson's disease.

Primobolan is also called as primo and the chemical name is Methenolone. It is the most popular injectable anabolic androgenic steroid for cutting cycles. Primobolan got famous by the legend Arnold Schwarzenegger. Primo is considered a fairly weak steroid. When it interacts with the aromatase enzyme, it does not form any estrogens.

The protein labeling market is expected to reach USD 1,894.5 Million by 2020 from USD 1,089.5 Million in 2015, growing at a CAGR of 11.7% from 2015 to 2020. A strong trend of increasing healthcare expenditure will majorly drive the growth of the market. Other growth factors include increasing R&D spending and growth in proteomics research. The increasing use of protein labeling in in vitro labeling, in vivo labeling, and bioorthogonal labeling methods will provide opportunities for market growth.