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Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy women. Peterson CA, Heffernan ME. J Inflamm (Lond). 2008 Jul 24;5:10. PMID: 18652680 doi:10.1186/1476-9255-5-10 Conclusion Serum 25(OH)D status is inversely related to TNF-α concentrations in healthy women, which may in part explain this vitamin's role in the prevention and treatment of inflammatory diseases. Results gleaned from this investigation also support the need to re-examine the biological basis for determining optimal vitamin D status.

Vitamin D status and its relationship to body fat, final height, and peak bone mass in young women.\nKremer R, Campbell PP, Reinhardt T, Gilsanz V.\nJ Clin Endocrinol Metab. 2009 Jan;94(1):67-73. Epub 2008 Nov 4.\nPMID: 18984659

Review: vitamin D, immunity and lupus. Cutolo M, Otsa K. Lupus. 2008;17(1):6-10. Review. PMID: 18089676 DOI: 10.1177/0961203307085879

Dietary Reference Intakes for vitamin D: justification for a review of the 1997 values. Yetley EA, Brulé D, Cheney MC, Davis CD, Esslinger KA, Fischer PW, Friedl KE, Greene-Finestone LS, Guenther PM, Klurfeld DM, L'abbe MR, McMurry KY, Starke-Reed PE, Trumbo PR. Am J Clin Nutr. 2009 Jan 28. [Epub ahead of print] PMID: 1917674 doi:10.3945/ajcn.2008.26903

Autism and vitamin D. Cannell JJ. Med Hypotheses. 2008;70(4):750-9. Epub 2007 Oct 24. PMID: 17920208

Does nutritional intake differ between children with autism spectrum disorders and children with typical development? Herndon AC, Diguiseppi C, Johnson SL, Leiferman J, Reynolds A. J Autism Dev Disord. 2009 Feb;39(2):212-22. Epub 2008 Jul 4. PMID: 18600441 DOI: 10.1007/s10803-008-0606-2

Scientists have long known that a lack of vitamin D can weaken our bones. A new study shows that low levels of this nutrient may also be linked to a higher chance of dying early from heart and circulation problems, as well as other causes.

Vitamin D protects bone, preserves muscle strength, and regulates cell growth and energy metabolism. It also offers some protection against cancer and other disease, but are these effects really important for health and life expectancy? The answer seems to be a resounding yes.

I stumbled on one of the growing number of local media stories on the power of vitamin D. \nIn one story, a purported "expert" was talking about the benefits of "high-dose" vitamin D, meaning up to 1000, even 2000 units per day. \nI regard this as high-dose---for an infant. \nJudging by my experiences, now numbering well over 1000 patients over three years time, I'd regard this dose range not as "high dose," nor moderate dose, perhaps not even low dose. I'd regard it as barely adequate.

Vitamin D and autoimmune rheumatic diseases. Cutolo M. Rheumatology (Oxford). 2009 Mar;48(3):210-2. Epub 2008 Oct 17. PMID: 18930963 doi:10.1093/rheumatology/ken394

Vitamin D supplementation during Antarctic winter. Smith SM, Gardner KK, Locke J, Zwart SR. Am J Clin Nutr. 2009 Apr;89(4):1092-8. Epub 2009 Feb 18. PMID: 19225122 doi:10.3945/ajcn.2008.27189

Ecological Studies Of Ultraviolet B, Vitamin D And Cancer Since 2000. Grant WB, Mohr SB. Ann Epidemiol. 2009 Mar 6. [Epub ahead of print] PMID: 19269856 doi:10.1016/j.annepidem.2008.12.014

High prevalence of vitamin D inadequacy and implications for health.\nHolick MF.\nMayo Clin Proc. 2006 Mar;81(3):353-73. Review.\nPMID: 16529140 \ndoi: 10.4065/​81.3.353\n

NaturalNews) Researchers from Oxford University and the University of British Columbia have discovered that Vitamin D deficiency affects a section of the human genome already linked with multiple sclerosis (MS) risk, adding further weight to theories that this vitamin deficiency might play a role in development of the disease. "Here we show that the main environmental risk candidate -- vitamin D -- and the main gene region are directly linked and interact," said co-author George Ebers.

Long-term effects of giving nursing home residents bread fortified with 125 {micro}g (5000 IU) vitamin D3 per daily serving. Mocanu V, Stitt PA, Costan AR, Voroniuc O, Zbranca E, Luca V, Vieth R. Am J Clin Nutr. 2009 Feb 25. [Epub ahead of print] PMID: 19244376

Now a new and controversial book by an American doctor suggests that taking even higher levels of the vitamin - 10 to 15 times the recommended amounts - can work wonders. Dr James Dowd, who works at the Arthritis Institute of Michigan, has been prescribing vitamin D to people suffering from chronic disorders such as arthritis, back pain and headaches and the result, he claims, is a huge improvement in their symptoms. In his book, The Vitamin D Cure, Dr Dowd describes a number of success stories using this approach. One of his patients, Barbara, for instance, was obese, and suffered from arthritis in one leg as well as high blood pressure. As Dowd explains: "In the past I would have given her anti-inflammatory drugs, pain medication, a pill to lose weight and drug treatment for hypertension."