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In the flagship article, The ENCODE Project Consortium et al.5 provide a bird's-eye view of the updated encyclopedia, which contains newly added data sets from 6,000 experiments, performed on around 1,300 samples. By integrating these data sets, the consortium has created an online registry of candidate CREs. Most are classified as promoters or enhancers - CREs respectively located at or some distance from the genomic site at which transcription of a gene begins. The consortium tracked the activity of each candidate CRE, along with the proteins that bind to it in many different samples from various tissues. They used chromatin-looping data to link enhancers to genes that they might regulate. This online registry marks a true milestone, turning an overwhelming amount of genomic information into a searchable, filterable and retrievable encyclopedia of DNA elements, which is freely accessible at https://screen.encodeproject.org.

"Right now, the biggest impediment to thinking about the future of the humanities is that, thanks to this entrenched narrative of decline-because we've been crying wolf for so long-we already think we know what's going on. The usual suspects-student debt, postmodern relativism, vanishing jobs-are once again being trotted out. But the data suggest something far more interesting may be at work. The plunge seems not to reflect a sudden decline of interest in the humanities, or any sharp drop in the actual career prospects of humanities majors. Instead, in the wake of the 2008 financial crisis, students seem to have shifted their view of what they should be studying-in a largely misguided effort to enhance their chances on the job market. And something essential is being lost in the process."

"n a recent article in the New York Times, the development economist Seema Jayachandran discusses three studies that used Randomised Controlled Trials (or RCTs) to understand the benefits of enhancing the self-worth of poor people. Despite wide differences in context, all the cases explore the viability of 'modest interventions' to 'instill hope' in marginalised communities, concluding that 'remarkable improvements' in the quest for poverty reduction are possible."

"With each interaction, Alexa is training to hear better, to interpret more precisely, to trigger actions that map to the user's commands more accurately, and to build a more complete model of their preferences, habits and desires. What is required to make this possible? Put simply: each small moment of convenience - be it answering a question, turning on a light, or playing a song - requires a vast planetary network, fueled by the extraction of non-renewable materials, labor, and data. The scale of resources required is many magnitudes greater than the energy and labor it would take a human to operate a household appliance or flick a switch. A full accounting for these costs is almost impossible, but it is increasingly important that we grasp the scale and scope if we are to understand and govern the technical infrastructures that thread through our lives. III The Salar, the world's largest flat surface, is located in southwest Bolivia at an altitude of 3,656 meters above sea level. It is a high plateau, covered by a few meters of salt crust which are exceptionally rich in lithium, containing 50% to 70% of the world's lithium reserves. 4 The Salar, alongside the neighboring Atacama regions in Chile and Argentina, are major sites for lithium extraction. This soft, silvery metal is currently used to power mobile connected devices, as a crucial material used for the production of lithium-Ion batteries. It is known as 'grey gold.' Smartphone batteries, for example, usually have less than eight grams of this material. 5 Each Tesla car needs approximately seven kilograms of lithium for its battery pack. 6 All these batteries have a limited lifespan, and once consumed they are thrown away as waste. Amazon reminds users that they cannot open up and repair their Echo, because this will void the warranty. The Amazon Echo is wall-powered, and also has a mobile battery base. This also has a limited lifespan and then must be thrown away as waste. According to the Ay

"My long-term vision for a better rural farm policy in the future would include new wildlife corridors, agroforestry, walking paths and bike trails, natural prairies, restored wetlands, and a return to naturalized rivers. This would require returning some private land back to public land, of retiring a percentage of today's Midwestern farmland. These things would support wildlife, outdoors activities, and provide greater tourism opportunities in the Midwest. These things would protect the soil, water, and help with biodiversity compared to what it is today. They would also help to enhance the quality of life for those who are living in the Midwest and they would entice others to move there for new opportunities. And, more kids could grow up doing the outdoor activities that I did."

Large-scale irrigation infrastructure projects are back on the development agenda in sub-Saharan Africa after a near 30-year hiatus, despite projects having had disappointing results, with social and environmental side effects outweighing benefits. Such projects are planned in response to water scarcity pressures and are seen as a solution to intensify agricultural production, support rural economic development and enhance resilience to climate change.

In this Review, we outline the history and evolution of the burning embers and associated reasons for concern framework, focusing on the methodological approaches and advances. While the assessment framework and figure design have been broadly retained over time, refinements in methodology have occurred, including the consideration of different risks, use of confidence statements, more formalized protocols and standardized metrics. Comparison across reports reveals that the risk level at a given temperature has generally increased with each assessment cycle, reflecting accumulating scientific evidence. For future assessments, an explicit, transparent and systematic process of expert elicitation is needed to enhance comparability, quality and credibility of burning embers.

The complexity of an ecological community can be distilled into a network, where diverse interactions connect species in a web of dependencies. Species interact directly with each other and indirectly through environmental effects, however to our knowledge the role of these ecosystem engineers has not been considered in ecological network models. Here we explore the dynamics of ecosystem assembly, where species colonization and extinction depends on the constraints imposed by trophic, service, and engineering dependencies. We show that our assembly model reproduces many key features of ecological systems, such as the role of generalists during assembly, realistic maximum trophic levels, and increased nestedness with mutualistic interactions. We find that ecosystem engineering has large and nonlinear effects on extinction rates. While small numbers of engineers reduce stability by increasing primary extinctions, larger numbers of engineers increase stability by reducing primary extinctions and extinction cascade magnitude. Our results suggest that ecological engineers may enhance community diversity while increasing persistence by facilitating colonization and limiting competitive exclusion.