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"Case histories make contributions to science and practice, but they can also be highly misleading. We illustrate with our re-examination of the case of Jane Doe; she was videotaped twice, once when she was six years old and then eleven years later when she was seventeen. During the first interview she reported sexual abuse by her mother. During the second interview she apparently forgot and then remembered the sexual abuse. Jane's case has been hailed by some as the new proof of recovery of repressed or dissociated traumatic memories, and even as proof of the reliability of recovered memories of repeated abuse. Numerous pieces of "supporting evidence" were given in the original article for believing that the abuse occurred. Upon closer scrutiny, however, there are reasons to doubt not only the "supporting evidence," but also that the sexual abuse ever happened in the first place. Our analysis raises several general questions about the use of case histories in science, medicine, and mental health. There is a cautionary tale not only for those professionals who advance the case history, but also for those who base their theories on it or would readily accept it as proof."

"AMERICANS, particularly if they are of a certain leftward-leaning, college-educated type, worry about our country's blunders into other cultures. In some circles, it is easy to make friends with a rousing rant about the McDonald's near Tiananmen Square, the Nike factory in Malaysia or the latest blowback from our political or military interventions abroad. For all our self-recrimination, however, we may have yet to face one of the most remarkable effects of American-led globalization. We have for many years been busily engaged in a grand project of Americanizing the world's understanding of mental health and illness. We may indeed be far along in homogenizing the way the world goes mad. This unnerving possibility springs from recent research by a loose group of anthropologists and cross-cultural psychiatrists. Swimming against the biomedical currents of the time, they have argued that mental illnesses are not discrete entities like the polio virus with their own natural histories. These researchers have amassed an impressive body of evidence suggesting that mental illnesses have never been the same the world over (either in prevalence or in form) but are inevitably sparked and shaped by the ethos of particular times and places. In some Southeast Asian cultures, men have been known to experience what is called amok, an episode of murderous rage followed by amnesia; men in the region also suffer from koro, which is characterized by the debilitating certainty that their genitals are retracting into their bodies. Across the fertile crescent of the Middle East there is zar, a condition related to spirit-possession beliefs that brings forth dissociative episodes of laughing, shouting and singing. The diversity that can be found across cultures can be seen across time as well. In his book "Mad Travelers," the philosopher Ian Hacking documents the fleeting appearance in the 1890s of a fugue state in which European men would walk in a trance for hundreds of mile

"rom heroin and cocaine to sex and lies, Tetris and the ponies, the spectrum of human addictions is vast. But for Dr. Nora D. Volkow, the neuroscientist in charge of the National Institute on Drug Abuse, they all boil down to pretty much the same thing. She must say it a dozen times a day: Addiction is all about the dopamine. The pleasure, pain and devilish problem of control are simply the detritus left by waves of this little molecule surging and retreating deep in the brain. A driven worker with a colorful family history and a bad chocolate problem of her own, Dr. Volkow (pronounced VOHL-kuv), 55, has devoted her career to studying this chemical tide. And now, eight years into her tenure at the institute, the pace of addiction research is accelerating, propelled by a nationwide emergency that has sent her agency, with a $1.09 billion budget, into crisis mode. The toll from soaring rates of prescription drug abuse, including both psychiatric medications and drugs for pain, has begun to dwarf that of the usual illegal culprits. Hospitalizations related to prescription drugs are up fivefold in the last decade, and overdose deaths up fourfold. More high school seniors report recreational use of tranquilizers or prescription narcotics, like OxyContin and Vicodin, than heroin and cocaine combined. The numbers have alarmed drug policy experts, their foreboding heightened by the realization that the usual regulatory tools may be relatively unhelpful in this new crisis. As Dr. Volkow said to a group of drug experts convened by the surgeon general last month to discuss the problem, "In the past, when we have addressed the issue of controlled substances, illicit or licit, we have been addressing drugs that we could remove from the earth and no one would suffer." But prescription drugs, she continued, have a double life: They are lifesaving yet every bit as dangerous as banned substances. "The challenges we face are much more complex," Dr. Volkow said, "becau

"FOR a brief, heady period in the history of autism spectrum diagnosis, in the late '90s, I had Asperger syndrome. There's an educational video from that time, called "Understanding Asperger's," in which I appear. I am the affected 20-year-old in the wannabe-hipster vintage polo shirt talking about how keen his understanding of literature is and how misunderstood he was in fifth grade. The film was a research project directed by my mother, a psychology professor and Asperger specialist, and another expert in her department. It presents me as a young man living a full, meaningful life, despite his mental abnormality. "Understanding Asperger's" was no act of fraud. Both my mother and her colleague believed I met the diagnostic criteria laid out in the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The manual, still the authoritative text for American therapists, hospitals and insurers, listed the symptoms exhibited by people with Asperger disorder, and, when I was 17, I was judged to fit the bill. I exhibited a "qualified impairment in social interaction," specifically "failure to develop peer relationships appropriate to developmental level" (I had few friends) and a "lack of spontaneous seeking to share enjoyment, interests, or achievements with other people" (I spent a lot of time by myself in my room reading novels and listening to music, and when I did hang out with other kids I often tried to speak like an E. M. Forster narrator, annoying them). I exhibited an "encompassing preoccupation with one or more stereotyped and restricted patterns of interest that is abnormal either in intensity or focus" (I memorized poems and spent a lot of time playing the guitar and writing terrible poems and novels). The general idea with a psychological diagnosis is that it applies when the tendencies involved inhibit a person's ability to experience a happy, normal life. And in my c

"FOR the last few weeks, the sex abuse scandal at Penn State and the harassment claims against the Republican presidential candidate Herman Cain have been fodder for discussion at my house. The same is true, I assume, around the country. Putting aside the specifics of each case, one question that has come up is, "What would I do?" That is, if I saw what seemed to be a crime or unethical act committed by a respected colleague, coach, teacher or friend, would I storm in and stop it? Would I call the authorities immediately? Would I disregard the potentially devastating impact on my job or workplace or beloved institution? Absolutely, most of us would probably reply. I think so, others might respond. And the most honest answer? I don't know. As much as we would like to think that, put on the spot, we would do the right - and perhaps even heroic - thing, research has shown that that usually isn't true. "People are routinely more willing to be critical of others' ethics than of their own," said Francesca Gino, an associate professor at Harvard Business School, and two other authors in the journal article "See No Evil: When We Overlook Other People's Unethical Behavior." The article appeared as a chapter in the book "Social Decision Making" (Psychology Press, 2009). "People believe they are more honest and trustworthy than others and they try harder to do good." But our faith in ourselves isn't borne out by history or research, something the Times columnist David Brooks pointed out in his column this week. The most well-known example of this in academia is the experiment conducted by the Yale University psychologist Stanley Milgram in the early 1960s. In the experiment, participants were "teachers" and, unbeknown to the participants, the "learner" was really an actor. The teacher was to instruct the learner in word pairs. For every wrong answer, the teacher could shock the learner, increasing the intensity of the shock for

"Science all but confirms that humans are hard-wired to respond to music. Studies also suggest that someday music may even help patients heal from Parkinson's disease or a stroke. In The Power of Music, Elena Mannes explores how music affects different groups of people and how it could play a role in health care. Mannes tracked the human relationship with music over the course of a life span. She tells NPR's Neal Conan that studies show that infants prefer "consonant intervals, the smooth-sounding ones that sound nice to our Western ears in a chord, as opposed to a jarring combination of notes." In fact, Mannes says the cries of babies just a few weeks old were found to contain some of the basic intervals common to Western music. She also says scientists have found that music stimulates more parts of the brain than any other human function. That's why she sees so much potential in music's power to change the brain and affect the way it works. Mannes says music also has the potential to help people with neurological deficits. "A stroke patient who has lost verbal function - those verbal functions may be stimulated by music," she says. One technique, known as melodic intonation therapy, uses music to coax portions of the brain into taking over for those that are damaged. In some cases, it can help patients regain their ability to speak. And because of how we associate music with memories, Mannes says such techniques could also be helpful for Alzheimer's patients. Less recently, archaeologists have discovered ancient flutes - one of which is presumed to be the oldest musical instrument in the world - that play a scale similar to the modern Western scale. "And remarkably," Mannes says, "this flute, when played, produces these amazingly pure tones." It's a significant discovery because it adds to the argument that musical ability and interest were present early in human history."

"Psychopathic killers are the basis for some must-watch TV, but what really makes them tick? Neuroscientist Jim Fallon talks about brain scans and genetic analysis that may uncover the rotten wiring in the nature (and nurture) of murderers. In a too-strange-for-fiction twist, he shares a fascinating family history that makes his work chillingly personal."

We humans are such complex beasts. Why is it that we can be so wonderful and yet so awful, eccentric and prosaic, enigmatic and obvious, witty and dull, and all of these at once? All in the Mind, presented by Natasha Mitchell, is Radio National's weekly foray into all things mental - a program about the mind, brain and behaviour. From dreaming to depression, addiction to artificial intelligence, consciousness to coma, psychoanalysis to psychopathy, free will to forgetting - All in the Mind explores the human condition through the mind's eye. Our mental machinery remains one of the greatest mysteries of this or any other age, performing for us the most incredible feats of perception, cognition and coordination. Scientists, theologians, philosophers and armchair psychologists alike have long debated its form and function. And yet, the mind, in all its madness and brilliance, continues to elude us. All in the Mind brings together unexpected voices, themes and ideas and engages with both leading thinkers and personal stories. Psychology and human behaviour are only part of the equation. The program's scope is considerably broader and explores themes in science, religion, health, philosophy, education, history and pop culture, with the mind as the key focus.

As behavioral genetics enters a second century, the field's oldest research method remains both relevant and controversial. "Twins have a special claim upon our attention; it is, that their history affords means of distinguishing between the effects of tendencies received at birth, and those that were imposed by the special circumstances of their after lives." -- Sir Francis Galton, 19th century behavioral genetics pioneer, Inquiries into Human Faculty and its Development,1875 More than a century after Galton's observation, twin studies remain a favorite tool of behavioral geneticists. Researchers have used twin studies to try to disentangle the environmental and genetic backgrounds of a cornucopia of traits, from aggression to intelligence to schizophrenia to alcohol dependence. But despite the popularity of twin studies, some psychologists have long questioned assumptions that underlie them--like the supposition that fraternal and identical twins share equal environments or that people choose mates with traits unlike their own. The equal environments assumption, for example, has been debated for at least 40 years. Many researchers have found evidence that the assumption is valid, but others remain skeptical (see Further Reading below). Overall, twin studies assumptions remain controversial, says psychologist James Jaccard, PhD, a psychologist who studies statistical methods at the University at Albany of the State University of New York. In response, though, researchers are working to expand and develop twin study designs and statistical methods. And while the assumptions question remains a stumbling block for some researchers, many agree twin studies will continue to be an important tool--along with emerging genome and molecular research methods (see article page 42)--in shedding light on human behavioral genetics."