When Pantelis Georgiou and his fellow biomedical engineers at Imperial College London decided to design an intelligent insulin pump for diabetes patients, they started at the source. "We asked ourselves, what does a pancreas do to control blood glucose?" Georgiou recalls.
The answer is pretty well known: The organ relies primarily on two populations of cells—beta cells, to secrete insulin when blood glucose is high, and alpha cells, which release a hormone called glucagon when glucose levels are low. "We simulated them both in microchip form," Georgiou says. This biomimetic approach diverges from today's dominant method of delivering only insulin using a relatively simple control system.
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