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Our grins are not as simple as they seem. There are a myriad different ways to smile - and some of them can conceal some less than happy feelings.

"Truly effective, synergistic, collaboration is an elusive beast at the best of times and the idea of making it work at scale, for decentralised projects and organisations, is possibly the essential challenge of our times. If we want to work out how to work together more effectively, to build an equitable and abundant world for all, it seems important to recognise, what hinders collaboration, to identify great examples of effective collaboration and to at least attempt to identify if there are any key themes which we can build on and incorporate into our work."

The only way out of our Big Tech problem is up and through. If our future is not reliant upon high tech, it will be because civilization has fallen. Big Tech wired together a planetary, species-wide nervous system that, with the proper reforms and course corrections, is capable of seeing us through the existential challenge of our species and planet. Now it's up to us to seize the means of computation, putting that electronic nervous system under democratic, accountable control.

With this, we now know the exact mRNA contents of the BNT162b2 vaccine, and for most parts we understand why they are there: The CAP to make sure the RNA looks like regular mRNA A known successful and optimized 5' untranslated region (UTR) A codon optimized signal peptide to send the Spike protein to the right place (copied 100% from the original virus) A codon optimized version of the original spike, with two 'Proline' substitutions to make sure the protein appears in the right form A known successful and optimized 3' untranslated region A slightly mysterious poly-A tail with an unexplained 'linker' in there The codon optimization adds a lot of G and C to the mRNA. Meanwhile, using Ψ (1-methyl-3'-pseudouridylyl) instead of U helps evade our immune system, so the mRNA stays around long enough so we can actually help train the immune system.

August (2020), Democrats introduced a bill in Congress to block manufacturers' limits on medical devices, spurred by the pandemic. In Europe, the European Commission announced plans in March for new right-to-repair rules that would cover phones, tablets, and laptops by 2021.

"Medical R&D should respond to specific priority health needs. Opening up the R&D process to a wide range of contributors and stakeholders will allow the design of medicines that are better adapted to the needs of the end users, and will define the preferred product characteristics (PPCs) and target product profile (TPP) that will guide all the phases of product development. In OS, there are no insiders, meaning that strategic decisions may be made through informed community debate against the agreed-upon TPP. The broader community is thus involved in designing how a product will be developed, defining the studies that will be done, and establishing the criteria that will be applied for making stop/go decisions. In order to achieve this, investments are needed to build online communities and platforms that help groups collaborate effectively."

Dans le monde du recrutement, comme partout ailleurs, la digitalisation gagne du terrain chaque année sur un métier pourtant lié en grande majorité à des compétences émotionnelles humaines plutôt qu'à du pragmatisme robotisé. De nombreuses entreprises en ont d'ailleurs fait leur fonds de commerce, en promouvant des solutions capables, dans le cadre d'un recrutement, de trouver la perle rare ou de faciliter ou d'améliorer le premier filtre des CV.

La citoyenneté numérique désigne le maniement efficace et positif des technologies numériques (créer, travailler, partager, établir des relations sociales, rechercher, jouer, communiquer et apprendre), la participation active et responsable (valeurs, aptitudes, attitudes, connaissance) aux communautés (locales, nationales, mondiales) à tous les niveaux (politique, économique, social, culturel et interculturel), l'engagement dans un double processus d'apprentissage tout au long de la vie (dans des structures formelles, informelles et non formelles) et la défense continue de la dignité humaine.