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" Electronic Health Records (EHR, EMR) Blockchain beyond EHRs: Transforming value-based payment, precision medicine, patient-centric care While EHRs and information security get all the attention, there are more immediate opportunities for the distributed digital ledger technology."

"Medical R&D should respond to specific priority health needs. Opening up the R&D process to a wide range of contributors and stakeholders will allow the design of medicines that are better adapted to the needs of the end users, and will define the preferred product characteristics (PPCs) and target product profile (TPP) that will guide all the phases of product development. In OS, there are no insiders, meaning that strategic decisions may be made through informed community debate against the agreed-upon TPP. The broader community is thus involved in designing how a product will be developed, defining the studies that will be done, and establishing the criteria that will be applied for making stop/go decisions. In order to achieve this, investments are needed to build online communities and platforms that help groups collaborate effectively."

With this, we now know the exact mRNA contents of the BNT162b2 vaccine, and for most parts we understand why they are there: The CAP to make sure the RNA looks like regular mRNA A known successful and optimized 5' untranslated region (UTR) A codon optimized signal peptide to send the Spike protein to the right place (copied 100% from the original virus) A codon optimized version of the original spike, with two 'Proline' substitutions to make sure the protein appears in the right form A known successful and optimized 3' untranslated region A slightly mysterious poly-A tail with an unexplained 'linker' in there The codon optimization adds a lot of G and C to the mRNA. Meanwhile, using Ψ (1-methyl-3'-pseudouridylyl) instead of U helps evade our immune system, so the mRNA stays around long enough so we can actually help train the immune system.