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I've always argued that wireframes should come later in the web design process after copy and persuasive elements have been established.

Zakary Kinnaird argues there may be no good time for wireframes.

I can't test wireframes, esp. if they contain Lorem Ipsum copy. So wireframes lock in design elements before we even know what visitors prefer. Good comments as well.

Wireframes are one of the tools I use to communication page changes to Conversion Sciences clients. If you've been through this with me, you'll know that I believe in pen and "paper." My favorite commandment:  "Thou shall not wireframe alone."

Create wireframes in a collaborative space.