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Non-coding RNAs (ncRNAs) are functional RNA molecules that cannot be translated into proteins. Common regulatory ncRNAs include miRNA, lncRNA, circRNA, piRNA, and so on. There are many ways for non-coding RNAs to function. They can interact with proteins, DNA and RNA, and participate in various cellular activities. Increasing experimental datas proved that they play regulatory roles in many biological processes such as gene silencing, cell differentiation, protein synthesis and functional regulation, metabolic regulation, organ development, etc.

MicroRNA(miRNA) is a class of endogenous non-coding RNA found in eukaryotes with regulatory functions. They are about 20~25 nt. miRNAs are evolutionally-conserved and have a rich variety of species, they are not translated into proteins, but play an important role in regulating gene expression. miRNA can specifically bind to complementary regions within messenger RNA(mRNA) to promote its degradation or inhibit translation. miRNA is widely involved in cell proliferation, differentiation, apoptosis and cell cycle regulation, and plays a key role in gene experiments.

Guanosine 5 monophosphate disodium salt hydrate GMP·Na2 is a kind of scientific research reagent, widely used in molecular biology, pharmacology and other scientific research, is strictly prohibited for human body. GMP is a nucleoside monophosphoric acid that is phosphorylated to gtp and incorporated into ribonucleic acid (rna s) by various rna polymerases. GMP can be used to study the regulation of glutamate neurotransmission.

Hanbio offers gene delivery solutions and have been focusing on virus packaging for more than ten years, we also pay attention to the research field of autophagy, CRISPR/Cas9 and non-coding RNA. As a R & D enterprise, Hanbio has independently developed reagent products, including molecular and cellular reagents.

Lentivirus vector is a gene therapy vector developed on the base of HIV-1 (human immunodeficiency virus type 1). Lentivirus vector is a powerful tool for introduction of exogenous genes, with the advantages of wide infection spectrum, effective infection and long-term stable expression of exogenous genes. Now the lentivirus system has been widely used in various cell lines for gene overexpression, RNA interference, microRNA research, as well as in vivo experiments.

Luciferase is a general term for enzymes that can produce bioluminescence in nature, with the most representative ones are F-Luciferase from fireflies and R-Luciferase from renilla. Under the catalysis of luciferase, luciferin can efficiently convert to oxidized luciferin and emit strong fluorescence at the same time. Therefore, researchers used luciferase to develop a highly sensitive and convenient gene reporter system. Currently, this system is widely applied in various fields, including transcription factor binding site and promoter activity analysis, RNA degradation, signal transduction, drug screening, and in vivo animal imaging.

The mycoplasma, lacking a cell wall, is the smallest prokaryotic cell. During the process of cell culture, the contamination rate of mycoplasma exceeds 60%. When cells (especially passage cells) are contaminated by mycoplasma, it alters the expression of DNA, RNA, and proteins within these cells. Severe contamination leads to slow cell growth, changes in cellular morphology, and cytomorphy development. Consequently, preventing mycoplasma contamination during cell culture remains a global challenge.

Vitamin B4 (adenine), also known as 6-aminopurine, is one of the four nucleobases that make up DNA and RNA molecules, with the chemical formula C5H5N5. It exists mainly in the form of adenine nucleotides in vivo. It is involved in the formation of a variety of important intermediate substances, such as ATP and NADP, in metabolic pathways in vivo. Foods that contain more vitamin B4 are: animal offal, meat, soy products, shrimp, sardines, oysters, spinach, black fungus, squid, mushrooms, etc. Because vitamin B4 is heat-resistant, there is less loss during processing and cooking, and the content of vitamin B4 in food is almost unchanged after long-term storage in a dry environment.

As a fluorescent compound, rGis commonly used to detect DNA/RNA modifications. For the supply of the product. Huaren is a good choice for lab scale run and scalable production.

GDP·Na2 is a kind of research reagent, widely used in molecular biology, pharmacology and other scientific research. Gdp guanosine diphosphate (GDP) is a substrate for pyruvate kinase, capable of producing GTP for RNA biosynthesis.