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The mycoplasma, lacking a cell wall, is the smallest prokaryotic cell. During the process of cell culture, the contamination rate of mycoplasma exceeds 60%. When cells (especially passage cells) are contaminated by mycoplasma, it alters the expression of DNA, RNA, and proteins within these cells. Severe contamination leads to slow cell growth, changes in cellular morphology, and cytomorphy development. Consequently, preventing mycoplasma contamination during cell culture remains a global challenge.