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Clinical Chemistry - 1997 NACB Symposium - Evaluation of the newborn's blood gas status - This paper discusses considerations for interpretation of blood gases in the newborn period. Blood gas measurements and noninvasive estimations provide important information about oxygenation. Its determined that Blood gas measurements and complementary, noninvasive monitoring techniques provide the clinician with information essential to patient assessment, therapeutic decision making, and prognostication. Blood gas measurements are as important for ill newborn infants as for other critically ill patients, but unique challenges are provided by rapidly changing physiology, difficult access to arterial and mixed venous sampling sites, and small blood volumes.