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Matti Narkia

DCA and vanadium combination - The DCA Site - Updating You on DCA and Cancer - Dichloro... - 1 views

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    Simultaneously Blocking Glycolysis and Fat Metabolism Can the use of DCA and a fatty acid metabolism blocker together force more cancer cells into using aerobic metabolism? Tim McGough used green tea extract, which contains EGCG, in his fantastic response. DCA works by reactivating mitochondria and shifts metabolism from glycolysis to glucose oxidation. Hopefully the cancer cell will then undergo apoptosis. However, cancer cells have an alternate energy source: fat metabolism. This page explores to possibility of blocking fat metabolism to help force the cell into apoptosis. Oral squamous cell carcinoma is a cancer that does not respond well to DCA. This study, Head and Neck Cancer Cell Lines Are Resistant to Mitochondrial-Depolarization-Induced Apoptosis states: "Results: ΔΨm in head and neck cell lines started to show slight loss of ΔΨm, while HL-60 showed significant loss of ΔΨm after 30 min of treatment. All cell lines demonstrated complete mitochondrial depolarization within 24 h, however, only the control cell line HL-60 underwent apoptosis. In addition, HNSCC cell lines did not demonstrate cytoplasmic cytochrome c release despite significant mitochondrial membrane depolarization, while HL-60 cell initiated apoptosis and cytochcrome c release after 24 h of treatment. Conclusions: Head and neck cancer cell lines exhibit defects in mitochondrial-membrane-depolarization-induced apoptosis as well as impaired release of cytochrome c despite significant mitochondrial membrane depolarization. Proximal defects in the mitochondrial apoptosis pathway are a feature of HNSCC.(head and neck squamous cell carcinoma)" Note that although the cell lines were depolarized, apoptosis did not occur. So I checked to see if fatty acid metabolism is used by squamous cell carcinoma.
Matti Narkia

The role of botulinum toxin in the management of head and neck cancer patients - Entrez... - 0 views

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    Laskawi R, Ellies M. The role of botulinum toxin in the management of head and neck cancer patients. Curr Opin Otolaryngol Head Neck Surg. 2007 Apr;15(2):112-6. PMID: 17413413 [PubMed - in process]
Matti Narkia

The beverage maté: a risk factor for cancer of the head and neck. - Head Neck... - 0 views

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    The beverage maté: a risk factor for cancer of the head and neck. Goldenberg D, Golz A, Joachims HZ. Head Neck. 2003 Jul;25(7):595-601. Review. PMID: 12808663 DOI: 10.1002/hed.10288
Matti Narkia

Combination Immunotherapy of Squamous Cell Carcinoma of the Head and Neck: A Phase 2 Tr... - 0 views

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    Combination immunotherapy of squamous cell carcinoma of the head and neck: a phase 2 trial. Barrera JL, Verastegui E, Meneses A, Zinser J, de la Garza J, Hadden JW. Arch Otolaryngol Head Neck Surg. 2000 Mar;126(3):345-51. PMID: 10722007
Matti Narkia

Simultaneously targeting epidermal growth factor receptor tyrosine kinase and cyclooxyg... - 0 views

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    Simultaneously targeting epidermal growth factor receptor tyrosine kinase and cyclooxygenase-2, an efficient approach to inhibition of squamous cell carcinoma of the head and neck. Chen Z, Zhang X, Li M, Wang Z, Wieand HS, Grandis JR, Shin DM. Clin Cancer Res. 2004 Sep 1;10(17):5930-9. PMID: 15355926
Matti Narkia

Head and Neck Cancer: An Expert Interview With Dr. Roger B. Cohen - 0 views

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    Innovations in the Treatment of Patients With Head and Neck Cancer: An Expert Interview With Dr. Roger B. Cohen
Matti Narkia

Chemokines and squamous cancer of the head and neck: targets for therapeutic interventi... - 0 views

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    Yeudall WA, Miyazaki H. Chemokines and squamous cancer of the head and neck: targets for therapeutic intervention? Expert Rev Anticancer Ther. 2007 Mar;7(3):351-60. PMID: 17338654 [PubMed - in process]
Matti Narkia

Eicosanoid metabolism in squamous cell carcinoma cell lines derived from primary and me... - 0 views

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    Schroeder CP, Yang P, Newman RA, Lotan R. Eicosanoid metabolism in squamous cell carcinoma cell lines derived from primary and metastatic head and neck cancer and its modulation by celecoxib. Cancer Biol Ther. 2004 Sep;3(9):847-52. Epub 2004 Sep 18. P
Matti Narkia

A new radiation therapy treatment developed for head and neck cancer patients - 0 views

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    Most head-and-neck cancers that recur locally after prior full-dose conventional radiation therapy respond to Boron Neutron Capture Therapy (BNCT). These results were obtained in a Phase I/II study at the Helsinki University Hospital, Finland. The scienti
Matti Narkia

Boron Neutron Capture Therapy in the Treatment of Locally Recurred Head and Neck Cancer... - 0 views

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    Boron Neutron Capture Therapy in the Treatment of Locally Recurred Head and Neck Cancer. Corrected Proof, 7 August 2007 Leena Kankaanranta, Tiina Seppälä, Hanna Koivunoro, Kauko Saarilahti, Timo Atula, Juhani Collan, Eero Salli, Mika Kortesniemi, Jouni
Matti Narkia

Sulindac Induces Apoptosis and Inhibits Tumor Growth in vivo in Head and Neck Squamous ... - 0 views

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    Scheper MA, Nikitakis NG, Chaisuparat R, Montaner S, Sauk JJ. Sulindac Induces Apoptosis and Inhibits Tumor Growth in vivo in Head and Neck Squamous Cell Carcinoma. Neoplasia. 2007 Mar;9(3):192-9. PMID: 17401459 [PubMed - in process]
Matti Narkia

Tetrathiomolybdate promotes tumor necrosis and prevents distant metastases by suppressi... - 0 views

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    Tetrathiomolybdate promotes tumor necrosis and prevents distant metastases by suppressing angiogenesis in head and neck cancer -- Hassouneh et al. 6 (3): 1039 -- Molecular Cancer Therapeutics
Matti Narkia

A Novel Anti-angiogenesis Strategy for the Treatment of Head and Neck Cancer - News Arc... - 0 views

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    A Novel Anti-angiogenesis Strategy for the Treatment of Head and Neck Cancer - News Archive: Michigan Oncology Journal Summer 01
Matti Narkia

Inhibition of the Growth of Squamous Cell Carcinoma by Tetrathiomolybdate-Induced Coppe... - 0 views

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    C. Cox, S. D. Merajver, S. Yoo, R. D. Dick, G. J. Brewer, J. S.-J. Lee, and T. N. Teknos Inhibition of the Growth of Squamous Cell Carcinoma by Tetrathiomolybdate-Induced Copper Suppression in a Murine Model Arch Otolaryngol Head Neck Surg, July 1, 200
Matti Narkia

The challenging integration of platinum compounds, taxanes, and molecular-targeted ther... - 0 views

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    Awada A, Ismael G. The challenging integration of platinum compounds, taxanes, and molecular-targeted therapies in the multidisciplinary treatment of squamous cell carcinoma of the head and neck. Curr Opin Oncol. 2007 May;19(3):177-9. PMID: 17414633 [
Matti Narkia

The role of taxanes and targeted therapies in locally advanced head and neck cancer - E... - 0 views

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    Specenier P, Vermorken JB. The role of taxanes and targeted therapies in locally advanced head and neck cancer. Curr Opin Oncol. 2007 May;19(3):195-201. PMID: 17414636 [PubMed - in process]
Matti Narkia

Sham vs. Wham: The Health Insider: The Beverage Yerba Maté May Have Ties to H... - 0 views

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    "Maté consumption plays a significant and independent role in the development of upper aeodigestive tract cancers," and "Maté drinking should be considered one of the risk factors for cancer of the neck and head."
Matti Narkia

Aldehyde dehydrogenase 2 and head and neck cancer: a meta-analysis implementing a Mende... - 0 views

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    Aldehyde dehydrogenase 2 and head and neck cancer: a meta-analysis implementing a Mendelian randomization approach. Boccia S, Hashibe M, Gallì P, De Feo E, Asakage T, Hashimoto T, Hiraki A, Katoh T, Nomura T, Yokoyama A, van Duijn CM, Ricciardi G, Boffetta P. Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):248-54. PMID: 19124505 doi: 10.1158/1055-9965.EPI-08-0462
Matti Narkia

Head And Neck Cancer Survivors Who Use Alcohol And Cigarettes Have Increased Death Risk - 0 views

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    "Cigarette smoking and alcohol consumption before head and neck cancer diagnosis strongly predicts the patient's future risk of death, according to published studies. Now, results of a new study show a similar effect among those who continued these habits after cancer diagnosis. "Most cancer survivors are counseled to quit smoking; despite this, many still smoke. In our study, 21 percent continued to smoke even after their cancer diagnosis, increasing their risk of death," said researcher Susan T. Mayne, Ph.D. "Similarly, we found that continued drinking increases the risk of death.""
Matti Narkia

BioVex To Report Phase I/II Clinical Trial Results For The Front Line Treatment Of Head... - 0 views

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    BioVex Inc, a company developing next generation biologics for the treatment and prevention of cancer and infectious disease, announced that the results from a Phase I/II combination study in previously untreated patients with head and neck cancer will be presented at the 2009 American Society of Clinical Oncology (ASCO) Annual Meeting, which will take place May 29, 2009 - June 2, 2009 in Orlando, FL.
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