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Matti Narkia

Vitamin D and prevention of breast cancer: pooled analysis. - ScienceDirect - The Journ... - 0 views

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    Vitamin D and prevention of breast cancer: pooled analysis. Garland CF, Gorham ED, Mohr SB, Grant WB, Giovannucci EL, Lipkin M, Newmark H, Holick MF, Garland FC. J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):708-11. PMID: 17368188 CONCLUSIONS: Intake of 2000 IU/day of Vitamin D(3), and, when possible, very moderate exposure to sunlight, could raise serum 25(OH)D to 52 ng/ml, a level associated with reduction by 50% in incidence of breast cancer, according to observational studies.
Matti Narkia

Aldehyde dehydrogenase 2 and head and neck cancer: a meta-analysis implementing a Mende... - 0 views

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    Aldehyde dehydrogenase 2 and head and neck cancer: a meta-analysis implementing a Mendelian randomization approach. Boccia S, Hashibe M, Gallì P, De Feo E, Asakage T, Hashimoto T, Hiraki A, Katoh T, Nomura T, Yokoyama A, van Duijn CM, Ricciardi G, Boffetta P. Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):248-54. PMID: 19124505 doi: 10.1158/1055-9965.EPI-08-0462
Matti Narkia

Vitamin D and prevention of colorectal adenoma: a meta-analysis - Cancer Epidemiol Bio... - 0 views

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    Vitamin D and prevention of colorectal adenoma: a meta-analysis.\nWei MY, Garland CF, Gorham ED, Mohr SB, Giovannucci E.\nCancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):2958-69.\nPMID: 18990737
Matti Narkia

Optimal Vitamin D Status for Colorectal Cancer Prevention: A Quantitative Meta Analysis... - 0 views

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    Gorham ED, Garland CF, Garland FC, Grant WB, Mohr SB, Lipkin M, Newmark HL, Giovannucci E, Wei M, Holick MF. Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. Am J Prev Med. 2007 Mar;32(3):210-6. PMID: 17296473 [
Matti Narkia

The Association of Solar Ultraviolet B (UVB) with Reducing Risk of Cancer: Multifactori... - 0 views

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    The association of solar ultraviolet B (UVB) with reducing risk of cancer: multifactorial ecologic analysis of geographic variation in age-adjusted cancer mortality rates. Grant WB, Garland CF. Anticancer Res. 2006 Jul-Aug;26(4A):2687-99. PMID: 16886679 CONCLUSION: These results provide additional support for the hypothesis that solar UVB, through photosynthesis of vitamin D, is inversely-associated with cancer mortality rates, and that various other cancer risk-modifying factors do not detract from this link. It is thought that sun avoidance practices after 1980, along with improved cancer treatment, led to reduced associations in the latter period. The results regarding solar UVB should be studied further with additional observational and intervention studies of vitamin D indices and cancer incidence, mortality and survival rates.
Matti Narkia

Meta-analysis: longitudinal studies of serum vitamin D and colorectal cancer risk. - Wi... - 0 views

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    Meta-analysis: longitudinal studies of serum vitamin D and colorectal cancer risk. Yin L, Grandi N, Raum E, Haug U, Arndt V, Brenner H. Aliment Pharmacol Ther. 2009 Jul 1;30(2):113-25. Epub 2009 Apr 15. PMID: 19392870 DOI: 10.1111/j.1365-2036.2009.04022.x Conclusions Our results support suggestions that serum 25(OH)D is inversely related to CRC risk.
Matti Narkia

Review and meta-analysis on vitamin D receptor polymorphisms and cancer risk -- Raimond... - 0 views

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    Review and meta-analysis on vitamin D receptor polymorphisms and cancer risk. Raimondi S, Johansson H, Maisonneuve P, Gandini S. Carcinogenesis. 2009 Jul;30(7):1170-80. Epub 2009 Apr 29. Review. PMID: 19403841
Matti Narkia

Meta-analysis of vitamin D, calcium and the prevention of breast cancer. - [Breast Canc... - 0 views

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    Meta-analysis of vitamin D, calcium and the prevention of breast cancer. Chen P, Hu P, Xie D, Qin Y, Wang F, Wang H. Breast Cancer Res Treat. 2009 Oct 23. [Epub ahead of print] PMID: 19851861 These results provide strong evidence that vitamin D and calcium have a chemopreventive effect against breast cancer.
Matti Narkia

Serum Vitamin D and Risk of Prostate Cancer in a Case-Control Analysis Nested Within th... - 0 views

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    Serum Vitamin D and Risk of Prostate Cancer in a Case-Control Analysis Nested Within the European Prospective Investigation into Cancer and Nutrition (EPIC). Travis RC, Crowe FL, Allen NE, Appleby PN, Roddam AW, Tjønneland A, Olsen A, Linseisen J, Kaaks R, Boeing H, Kröger J, Trichopoulou A, Dilis V, Trichopoulos D, Vineis P, Palli D, Tumino R, Sieri S, Bueno-de-Mesquita HB, van Duijnhoven FJ, Chirlaque MD, Barricarte A, Larrañaga N, González CA, Argüelles MV, Sánchez MJ, Stattin P, Hallmans G, Khaw KT, Bingham S, Rinaldi S, Slimani N, Jenab M, Riboli E, Key TJ. Am J Epidemiol. 2009 Apr 9. [Epub ahead of print] PMID: 19359375 doi:10.1093/aje/kwp022
Tonny Johnson

Diagnostic and prognostic cancer biomarker database - 1 views

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    A comprehensive diagnostic and prognostic cancer (oncology) biomarker database with cancer companion diagnostics biomarker pathway maps, which contain protein-protein interactions networks of cancer drug efficacy/response/predictive biomarkers. This database contains discovery, pre-clinical and clinical cancer biomarkers that were identified or validated using patient samples. The biomarkers include blood based cancer biomarkers, tumor biomarkers, urinary cancer biomarkers, fecal cancer biomarkers, saliva cancer biomarkers, breath cancer biomarkers etc. Patient/sample details, experimental results/observations, biological and molecular functional analysis, biological process analysis, protein-protein interaction networks of each biomarker are included in this database.Link (preview is available): http://www.sciclips.com/sciclips/diagnostic-prognostic-cancer-biomarker-main.do
Tonny Johnson

Strategies for Rational and Personalized Cancer Biomarker Discovery - 1 views

This scientific blog critically analyzes potential complexities associated with current biomarker discovery approaches. According to the scientific arguments that have been put forward in this blog...

rational biomarker personalized diagnostics targeted biomarkers genetic imaging theranostics medicine

started by Tonny Johnson on 27 Sep 12 no follow-up yet
Matti Narkia

pure sodium dichloroacetate - the way it should be - pureDCA.com - 0 views

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    Sodium dichloroacetate offered by PureDCA.com has more than 99% purity. We make it using a sophisticated synthesis process. No organic solvents are used during the production. We are currently the only providers of sodium dichloroacetate, which is equivalent in quality to NaDCA used in Medicor Cancer Centres. We ship internationally, with no exceptions. We are the only source of sodium dichloroacetate, which attaches a chemical analysis to every shipment, free of charge. The only place you can order our sodium dichloroacetate is the Cancer Virtual Community Store - Buy Sodium Dichloroacetate.
Matti Narkia

Sloan-Kettering - Garlic - 0 views

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    Derived from the bulb or clove of the plant. Garlic is used as a spice and to treat hyperlipidemia, hypertension, atherosclerosis, cancer, and infections. Processing can have a substantial effect on the chemical content in garlic; the volatile oil components are sensitive to heat and certain enzymes are acid-labile. Several oral garlic formulations are available, and clinical studies have addressed a variety of the proposed claims. Placebo-controlled trials on the cholesterol lowering effect of garlic yielded mixed results (16) (17) (18) (21) (22) (26). Studies evaluating the antithrombotic effects repeatedly have shown modest reduction in platelet aggregation, but varying levels of fibrinolytic activity. Research shows mixed effects with regard to reductions in blood glucose, blood pressure, or risk of cardiovascular disease (23). Frequently reported adverse events include bad breath, headache, fatigue, GI upset, diarrhea, sweating, and possible hypoglycemia (9). Because garlic is known to decrease platelet aggregation and potentially elevate the INR, it should not be used with anticoagulants or in patients with platelet dysfunction (15). Garlic appears to induce cytochrome p450 3A4 and may enhance metabolism of many medications (e.g. cyclosporin and saquinavir) (12). An analysis of several case-control studies in Europe suggests an inverse association between garlic consumption and risk of common cancers (25).
Matti Narkia

dichloroacetate, sodium dichloroacetate, buy dca, dichloroacetate cancer, dichloroaceta... - 1 views

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    f you are looking for Sodium Dichloroacetate or Miracle Mineral Supplement kit, then you are at the right place. We ship worldwide, also to the United States. We offer on-demand chemical compounds meeting the highest quality and safety standards. We support secure payment and 24 hours order processing as well as retail and bulk orders. Each batch comes with an individual chemical analysi
Matti Narkia

Antioxidant vitamins may protect against female cancer - 0 views

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    Increased intakes of vitamins C and E and beta-carotene may reduce the risk of cancer of the uterus, according to a new review and meta-analysis of the science to date. Writing in Cancer Causes and Control, US scientists report that for every 1,000 microgram increase per 1,000 kcal of diet of beta-carotene was associated with a 12 per cent reduction in the risk of endometrial cancer.
Matti Narkia

PPARalpha signaling mediates the synergistic cytotoxicity of clioquinol and docosahexae... - 0 views

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    The combination effects index (CI) analysis confirmed the synergy of clioquinol and clofibrate on inhibiting cancer cell viability. Using inhibitors to block PPARalpha signaling diminished the synergistic cytotoxicity of clioquinol and DHA. These results provide pharmacological evidence that the synergistic anticancer action of clioquinol and DHA is mediated by PPARalpha signaling in human cancer cells. PPARalpha signaling mediates the synergistic cytotoxicity of clioquinol and docosahexaenoic acid in human cancer cells. Tuller ER, Brock AL, Yu H, Lou JR, Benbrook DM, Ding WQ. Biochem Pharmacol. 2009 May 1;77(9):1480-6. Epub 2009 Feb 13. PMID: 19426685
Matti Narkia

Medicor Cancer Centres - DCA Therapy - 0 views

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    For the first time in the world, on December 7, 2007 we publicly shared our observational data from the treatment of 118 cancer patients with DCA. In March 2008 we updated our data from treating over 175 patients. As of August 2008, we have treated over 265 cancer patients with DCA. Results of the analysis of our latest data are very similar to our two earlier reports.
Matti Narkia

Berberine suppresses in vitro migration and invasion of human SCC-4 tongue sq... - 0 views

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    Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-kappaB, u-PA and MMP-2 and -9. Ho YT, Yang JS, Li TC, Lin JJ, Lin JG, Lai KC, Ma CY, Wood WG, Chung JG. Cancer Lett. 2009 Jul 8;279(2):155-62. Epub 2009 Feb 28. PMID: 19251361 doi:10.1016/j.canlet.2009.01.033 There is increasing evidence that urokinase-type plasminogen activator (u-PA) and matrix metalloproteinases (MMPs) play an important role in cancer metastasis and angiogenesis. Inhibition of u-PA and MMPs could suppress migration and invasion of cancer cells. Berberine, one of the main constituents of the plant Rhizoma coptidis, is a type of isoquinoline alkaloid, reported to have anti-cancer effects in different human cancer cell lines. There is however, no available information on effects of berberine on migration and invasion of human tongue cancer cells. Here, we report that berberine inhibited migration and invasion of human SCC-4 tongue squamous carcinoma cells. This action was mediated by the p-JNK, p-ERK, p-p38, IκK and NF-κB signaling pathways resulting in inhibition of MMP-2 and -9 in human SCC-4 tongue squamous carcinoma cells. Our Western blowing analysis also showed that berberine inhibited the levels of urokinase-plasminogen activator (u-PA). These results suggest that berberine down-regulates u-PA, MMP-2 and -9 expressions in SCC-4 cells through the FAK, IKK and NF-κB mediated pathways and a novel function of berberine is to inhibit the invasive capacity of malignant cells.
Vortege Ville

Prolonged sitting linked to breast cancer, colon cancer - 0 views

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    More than 90,000 new cancer cases a year may be due to physical inactivity and prolonged periods of sitting, a new analysis shows.
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