In vitro and in vivo immunomodulating and immunorestorative effects of Astragalus membranaceus.
Cho WC, Leung KN.
J Ethnopharmacol. 2007 Aug 15;113(1):132-41. Epub 2007 May 31.
PMID: 17611061
doi:10.1016/j.jep.2007.05.020
A nested case control study of plasma 25-hydroxyvitamin D concentrations and risk of colorectal cancer.
Wu K, Feskanich D, Fuchs CS, Willett WC, Hollis BW, Giovannucci EL.
J Natl Cancer Inst. 2007 Jul 18;99(14):1120-9. Epub 2007 Jul 10.
PMID: 17623801
Seneca Valley virus, a systemically deliverable oncolytic picornavirus, and the treatment of neuroendocrine cancers.
Reddy PS, Burroughs KD, Hales LM, Ganesh S, Jones BH, Idamakanti N, Hay C, Li SS, Skele KL, Vasko AJ, Yang J, Watkins DN, Rudin CM, Hallenbeck PL.
J Natl Cancer Inst. 2007 Nov 7;99(21):1623-33. Epub 2007 Oct 30.
PMID: 17971529
doi:10.1093/jnci/djm198
In vitro and in vivo anti-tumor effects of Astragalus membranaceus.
Cho WC, Leung KN.
Cancer Lett. 2007 Jul 8;252(1):43-54. Epub 2007 Jan 16.
PMID: 17223259
doi:10.1016/j.canlet.2006.12.001
Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo.\nChen Q, Espey MG, Sun AY, Lee JH, Krishna MC, Shacter E, Choyke PL, Pooput C, Kirk KL, Buettner GR, Levine M.\nProc Natl Acad Sci U S A. 2007 May 22;104(21):8749-54. Epub 2007 May 14.\nPMID: 17502596 \n doi: 10.1073/pnas.0702854104\n
Mitochondrially targeted effects of berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 mouse melanoma cells: comparison with direct effects on isolated mitochondrial fractions.
Pereira GC, Branco AF, Matos JA, Pereira SL, Parke D, Perkins EL, Serafim TL, Sardão VA, Santos MS, Moreno AJ, Holy J, Oliveira PJ.
J Pharmacol Exp Ther. 2007 Nov;323(2):636-49. Epub 2007 Aug 17.
PMID: 17704354
doi: 10.1124/jpet.107.128017
The present work shows that berberine is accumulated by mitochondria of a mouse melanoma cell line, leading to mitochondrial fragmentation and dysfunction, accompanied by decreased cellular energy charge. When the effect was compared with the results obtained on isolated mitochondrial fractions, it is observed that regardless of the system used, berberine is toxic for mitochondria. One major limitation of the present study (as in many others) is the lack of knowledge of the real concentration of berberine that reaches mitochondria in intact cells. Although we do not possess data regarding this aspect, it is wise to speculate that mitochondrial berberine concentrations will be much higher than in the bulk cytosol due to electrophoretic accumulation. We believe that the range of berberine concentrations accumulated by mitochondria in intact cells is within the range of concentrations used on isolated mitochondrial fractions in the present study. The present work not only provides insights on the mechanism by which berberine interferes with tumor cell proliferation, demonstrating previously unknown effects on mitochondrial physiology, but also raises a note of caution on the use of berberine as a nontoxic "natural" over-the-counter medication.
ScienceDaily (Dec. 25, 2007) - Researchers from the Universities of Warwick, Edinburgh, Dundee and the Czech Republic's Institute of Biophysics have discovered a new light-activated platinum-based compound that is up to 80 times more powerful than other platinum-based anti-cancer drugs and which can use "light activation" to kill cancer cells in much more targeted way than similar treatment
Vitamin d and its role in cancer and immunity: a prescription for sunlight.
Mullin GE, Dobs A.
Nutr Clin Pract. 2007 Jun;22(3):305-22. Review.
PMID: 17507731
(free full text PDF available)
Robien K, Cutler GJ, Lazovich D.
Vitamin D intake and breast cancer risk in postmenopausal women: the Iowa Women's Health Study.
Cancer Causes Control. 2007 Sep;18(7):775-82. Epub 2007 Jun 5.
PMID: 17549593 [PubMed - in process]
Park SY, Murphy SP, Wilkens LR, Nomura AM, Henderson BE, Kolonel LN.
Calcium and vitamin D intake and risk of colorectal cancer: the Multiethnic Cohort Study.
Am J Epidemiol. 2007 Apr 1;165(7):784-93. Epub 2007 Jan 10.
PMID: 17215380 [PubMed - indexed
The application of probiotics in cancer.
de Moreno de LeBlanc A, Matar C, Perdigón G.
Br J Nutr. 2007 Oct;98 Suppl 1:S105-10. Review.
PMID: 17922945
doi:10.1017/S0007114507839602
It was concluded that omega-3 fatty acid could inhibit the proliferation of pancreatic cancer cell line SW1990 cells and promote their apoptosis. The down-regulation of the cyclin E expression by omega-3 fatty acid might be one of the mechanisms for its anti-tumor effect on pancreatic cancer.
Modulatory effects of EPA and DHA on proliferation and apoptosis of pancreatic cancer cells.
Zhang W, Long Y, Zhang J, Wang C.
J Huazhong Univ Sci Technolog Med Sci. 2007 Oct;27(5):547-50.
PMID: 18060632
Israeli 'cancer shift' over heart disease mortality may be led by greater risk in women with high intake of n-6 fatty acids.
Shapira N.
Eur J Cancer Prev. 2007 Oct;16(5):486-94.
PMID: 17923822
doi: 10.1097/CEJ.0b013e3280145b6d
Population studies of Israeli Jews, Arabs, and women support the association of high n-6 polyunsaturated fatty acid intake with increased cancer risk and higher female sensitivity. Research findings suggest that gender and sex hormones may influence n-6 polyunsaturated fatty acid metabolism and carcinogenesis. This appears to be the first time gender has been proposed to modulate national cancer epidemiology, suggesting implications for differential nutritional prevention, warranting further research.