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suwhitte

Environmental Health Perspectives - 0 views

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    Environmental Health Perspectives (EHP) is a monthly journal of peer-reviewed research and news published by the U.S. National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services. EHP's mission is to serve as a forum for the discussion of the interrelationships between the environment and human health by publishing in a balanced and objective manner the best peer-reviewed research and most current and credible news of the field. With an impact factor of 6.12, EHP is the top monthly journal in public, environmental, and occupational health and the second-ranked monthly journal in environmental sciences. The environmental health sciences include many fields of study and increasingly comprise a multidisciplinary research area. EHP publishes articles from a wide range of scientific disciplines encompassing basic research; epidemiologic studies; risk assessment; relevant ethical, legal, social, environmental justice, and policy topics; longitudinal human studies; in vitro and in vivo animal research with a clear relationship to human health; and environmental medicine case reports. Because children are uniquely sensitive to their environments, EHP devotes a research section specifically to issues surrounding children's environmental health. Search current issue and archives for journal articles related to your topic.
Vanessa Ward

PLoS Biology: The Toxic Origins of Disease - 0 views

  • During embryonic development, steroid hormones like estrogen control gene-expression programs to coordinate cell differentiation, growth, organogenesis, and metabolism.
  • “The moment we published something on bisphenol A, the chemical industry went out and hired a number of corporate laboratories to replicate our research. What was stunning about what they did . . . was they hired people who had no idea how to do the work.”
  • “whole-animal toxicological studies,” which look at different endpoints than the more mechanistic studies do, Hughes says. “That doesn't let you look at changes in gene expression, changes in epigenetic control of gene expression.
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  • “I can tell you simply by the size of the animal which is DES-exposed and which isn't.”
  • “We found out that brain is a target, bone is a target . . . and now the new target is adipocytes.”
  • When he removed all the soy-derived plant estrogens from the mother's diet, he was astonished to see endogenous estradiol levels in the fetus rise, and the offspring become “horrifically obese.
  • Adding the weak plant estrogens back in the diet suppressed the far more potent endogenous estradiol, he discovered, by inhibiting an enzyme required to make it.
  • Recent evidence suggests that a class of ubiquitous environmental pollutants called organotins can also stimulate adipogenesis and interfere with energy balance
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    This was one of the first articles that I looked in depth at and pretty much read all of. It presents some of the original research done on the effects Bisphenol-A on reproductive development and mammary gland formamation and how in the process led to a noticeable pattern between exposure and weight gain. The study of obesogens is a new field that was in a way accidentally discovered. It has been hypothesized that estrogen causes embryonic cells to develop into fat cells through a process called adipogenesis by chemicals called organotins. New research to support this is addressed in this article.
Matthew Ragan

Open Science Directory - Home - 1 views

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    Access to scientific literature is very important for the scientific work in developing countries . As a result of different projects  a large collection of  e-journals is now available for researchers in developing countries. The number of Open Access Journals is growing steadily as we can see in the Directory of Open Access Journals. Major UNO organizations like WHO, FAO and UNEP have their specific programs for the scientific institutions in low-income countries. Finally a lot of universities, institutes and other organizations are supporting access programs. The most important are INASP, eIFL and eJDS.
Vanessa Ward

Endocrine Disruptors and the Obesity Epidemic -- Heindel 76 (2): 247 -- Toxicological S... - 1 views

  • "We are faced with the seeming paradox of increased adiposity at both ends of the birth weight spectrum—higher BMI with higher birth weight and increased central obesity with lower birth weight" (Oken and Gillman, 2003). Thus prevention of childhood and adult obesity must start in utero.
  • Indeed, many synthetic chemicals are actually used to increase weight in animals.
  • This article provides fascinating examples of chemicals that have been tested for toxicity by standard tests that resulted in weight gain in the animals at lower doses than those that caused any obvious toxicity.
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  • Chemicals having endocrine-disrupting activity rise to the top of the list as most act via receptors linked to activation of transcriptional activity.
  • In the adult, loss of circulating estrogen due to ovariectomy leads to increased body and adipose tissue weights. Estrogen receptor alpha knockout mice have a significantly increased body fat content, and estrogen decreases the activity of lipoprotein lipase
  • estrogenic endocrine-disrupting chemical bisphenol A at concentrations as low as 2 µg/ml, in the presence of insulin, stimulated differentiation of the 3T3L1 cells into adipocytes
  • he fact that an environmental chemical has the potential to stimulate growth of "preadipocytes" has enormous implications for the area of obesity and its control.
  • Differentiation could be inhibited and more potential fat cells could be formed, as seems to be the case with NP, or differentiation could be stimulated, as appears to be the case with BPA
  • Will these results extrapolate to the in vivo situation in rodents and other animal models?
  • Only time and more research will tell, but the door has been opened by the novel work being highlighted.
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    An article discussing how the area of research of obesity as a result of endocrine disrupting chemical exposure could be a beneficial area for intervention and prevention studies of obesity. This was one of the first articles I found directly addressing how endocrine disrupting chemical exposure can lead to a predisposition to obesity
Vanessa Ward

The Toxic Origins of Disease - 1 views

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    This was one of the first articles that I looked in depth at and pretty much read all of. It presents some of the original research done on the effects Bisphenol-A on reproductive development and mammary gland formamation and how in the process led to a noticeable pattern between exposure and weight gain. The study of obesogens is a new field that was in a way accidentally discovered. It has been hypothesized that estrogen causes embryonic cells to develop into fat cells through a process called adipogenesis by chemicals called organotins. New research to support this is addressed in this article.
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    This source is probably the biggest contribution to my paper. I accidentally shared it twice because I couldn't figure out how to edit the tags on this one since it didn't come from my library. I shared it before I figured out how to share the sources from my library to the group, I thought I had to do it separately.
Vanessa Ward

2010 March « Our Health and Environment Blog - 0 views

  • n addition to these issues, the prestigious international Endocrine Society published a seminal report last year stating that, “scientific research implies the impact of environmental substances in the generative roots of obesity.”
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    This is a letter addressing the "obesogen theory" and how the government could play a role in the prevention of obesity through the implementation of beter food regulations. I thought it was interesting to see a current letter addressing my topic and maybe it's a type source other people can look for that they may not have initially thought of.
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    A link in this article led me to another useful source. I didn't know that the White House was involved with this and that obesogens were brought to their attention until I read this letter. Bruce Blumberg signed the letter and since many of my sources are about his studies I thought it was neat how this letter tied together some of my research.
Anna McLean

Low dose effects of vinclozolin - 0 views

  • a few parts per million levels of vinclozolin contamination profoundly alter sexual development in male rats, producing significant feminization of the male reproductive tract, hypospadias, low sperm counts and other deformations.
  • When vinclozolin enters the body it is degraded into two metabolites. These metabolites then act as anti-androgens
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    Section of Our Stolen Future about vinclozolin. After searching around the web about this fungicide, it was interesting to see that most sources indicate that this chemical is not harmful. But, as we learned in class, recent research indicates otherwise.
Anna McLean

Our Stolen Future: New science on the impacts of endocrine disruptors on brain and beha... - 0 views

  • The sex steroids (testosterone, estrogen, etc.) contribute to, among other things, sexual differentiate of brain centers, and thereby, to the development of sexual identity and sexual behaviors
  • A rapidly increasing body of scientific research is revealing mechanisms of action, demonstrating impacts of disrupted development, and exploring links between intelligence, behavior and contamination experienced in the womb. What is emerging from this research is that brain and behavior are likely to be the most sensitive endpoints vulnerable to endocrine disruption. Many synthesized compounds in commercial use today, moreover, can derail neurological development.
  • April 2003. Exposure in the womb to extremely low levels of bisphenol A alters sexual differentiation of the brain and behavior in rats. More...
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  • September 2002. Dutch scientists report that boys exposed prenatally to higher levels of PCBs and dioxin are more likely to show demasculinized play behaviors. Girls and boys exposed to modestly elevated dioxin levels demonstrate more feminized play behaviors. The scientists suggest that that these alterations in play result from endocrine disruption of the development of sex-specific behaviors. More...
  • disturbed sexual differentiation of reproductive behavior, potentiating the expression of feminine sexual behavior and reducing masculine behavior."
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    This document is the web site for the book titled Our Stolen Future. There are numerous sections with "more..." links to full pages on the summarized topic. This is a great tool for my project.
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    Highlighted text indicates areas applicable to my topic.
Matthew Ragan

Estrogen Receptor Interacting with DNA - 0 views

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    Nuclear hormone receptor proteins form a class of ligand activated proteins that, when bound to specific sequences of DNA serve as on-off switches for transcription within the cell nucleus. These switches control the development and differentiation of skin, bone and behavioral centers in the brain, as well as the continual regulation of reproductive tissues.
suwhitte

Gordon Research Conferences - 2010 Program (Environmental Endocrine Disruptors) - 0 views

shared by suwhitte on 20 May 10 - Cached
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    At this upcoming conference and past conferences (see conference history), top scientists, studying endocrine disruption effects on humans and wildlife, meet to share the latest findings. Look over the program for topics and scientists - may be useful in identifying a topic for your project. I have attended two of these conferences and they were excellent and very current.
Anna McLean

ScienceDirect - Developmental Brain Research : Early vs. late maternal deprivation dif... - 1 views

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    Brandon, Order this from ILL. This is not the one I told you about it class, I am still searching to relocate that one. This may be of interest, though.
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