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Vanessa Ward

PLoS Biology: The Toxic Origins of Disease - 0 views

www.plosbiology.org/...journal.pbio.0050193

obesity endocrine origins of disease DES Blumberg Grun obesogen

shared by Vanessa Ward on 11 Jun 10 - Cached
  • During embryonic development, steroid hormones like estrogen control gene-expression programs to coordinate cell differentiation, growth, organogenesis, and metabolism.
  • “The moment we published something on bisphenol A, the chemical industry went out and hired a number of corporate laboratories to replicate our research. What was stunning about what they did . . . was they hired people who had no idea how to do the work.”
  • “whole-animal toxicological studies,” which look at different endpoints than the more mechanistic studies do, Hughes says. “That doesn't let you look at changes in gene expression, changes in epigenetic control of gene expression.
  • ...5 more annotations...
  • “I can tell you simply by the size of the animal which is DES-exposed and which isn't.”
  • “We found out that brain is a target, bone is a target . . . and now the new target is adipocytes.”
  • When he removed all the soy-derived plant estrogens from the mother's diet, he was astonished to see endogenous estradiol levels in the fetus rise, and the offspring become “horrifically obese.
  • Adding the weak plant estrogens back in the diet suppressed the far more potent endogenous estradiol, he discovered, by inhibiting an enzyme required to make it.
  • Recent evidence suggests that a class of ubiquitous environmental pollutants called organotins can also stimulate adipogenesis and interfere with energy balance
  • Vanessa Ward on 11 Jun 10
     
    This was one of the first articles that I looked in depth at and pretty much read all of. It presents some of the original research done on the effects Bisphenol-A on reproductive development and mammary gland formamation and how in the process led to a noticeable pattern between exposure and weight gain. The study of obesogens is a new field that was in a way accidentally discovered. It has been hypothesized that estrogen causes embryonic cells to develop into fat cells through a process called adipogenesis by chemicals called organotins. New research to support this is addressed in this article.
Vanessa Ward

The Toxic Origins of Disease - 1 views

www.plosbiology.org/...10.1371%2Fjournal.pbio.0050193

shared by Vanessa Ward on 29 May 10 - Cached
  • Vanessa Ward on 29 May 10
     
    This was one of the first articles that I looked in depth at and pretty much read all of. It presents some of the original research done on the effects Bisphenol-A on reproductive development and mammary gland formamation and how in the process led to a noticeable pattern between exposure and weight gain. The study of obesogens is a new field that was in a way accidentally discovered. It has been hypothesized that estrogen causes embryonic cells to develop into fat cells through a process called adipogenesis by chemicals called organotins. New research to support this is addressed in this article.
  • Vanessa Ward on 11 Jun 10
     
    This source is probably the biggest contribution to my paper. I accidentally shared it twice because I couldn't figure out how to edit the tags on this one since it didn't come from my library. I shared it before I figured out how to share the sources from my library to the group, I thought I had to do it separately.
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