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suwhitte

Why Chemicals Called Obesogens May Make You Fat - Newsweek.com - 0 views

www.newsweek.com/215179

EED obesogen

shared by suwhitte on 20 May 10 - Cached
  • suwhitte on 20 May 10
     
    Provides a basic description of obesogens and how they are thought to work. Good place to start.
Vanessa Ward

2010 March « Our Health and Environment Blog - 0 views

ourhealthandenvironment.wordpress.com/...03

obesity epidemic obesogens endocrine society

shared by Vanessa Ward on 06 Jun 10 - Cached
  • n addition to these issues, the prestigious international Endocrine Society published a seminal report last year stating that, “scientific research implies the impact of environmental substances in the generative roots of obesity.”
  • Vanessa Ward on 06 Jun 10
     
    This is a letter addressing the "obesogen theory" and how the government could play a role in the prevention of obesity through the implementation of beter food regulations. I thought it was interesting to see a current letter addressing my topic and maybe it's a type source other people can look for that they may not have initially thought of.
  • Vanessa Ward on 11 Jun 10
     
    A link in this article led me to another useful source. I didn't know that the White House was involved with this and that obesogens were brought to their attention until I read this letter. Bruce Blumberg signed the letter and since many of my sources are about his studies I thought it was neat how this letter tied together some of my research.
Vanessa Ward

San Francisco Medical Society | The Weight of Evidence - 0 views

www.sfms.org/...Template.cfm

SFMS Blumberg Grun obesity epidemic endocrine disruption EDCs obesity

shared by Vanessa Ward on 11 Jun 10 - Cached
  • “leading to neglect of other plausible mechanisms and well-intentioned but potentially ill-founded proposals for reducing obesity rates”
  • Since publication of that review, substantial evidence has emerged that increases the plausibility of one of the alternative mechanisms suggested by Keith et al: disruption of weight regulation by endocrine-disrupting chemicals (EDCs) in the environment.
  • Concerns about the potential contribution of EDCs to childhood obesity build from two considerations, one out of human biology and the other from animal experiments
  • ...7 more annotations...
  • Prior
  • toxicologists were concerned more with weight loss, which was seen as an adverse outcome.
  • Many of these chemicals alter the behavior of specific genes that are involved in determining the number of fat cells (adipocytes) an individual will have as an adult.
  • he list of contaminants implicated by animal studies is substantial, including several estrogenic EDCs such as DES, bisphenol A, soy phytoestrogens
  • Almost no human data are available to test the obesogen hypothesis in people. No epidemiological evidence exists, because the hypothesis is so new
  • One in vitro experiment, however, has demonstrated that exposure to obesogens increases the rate of conversion of human stem cells to adipocytes (Kirchner et al 2010), confirming the validity of the basic mechanism and the relevance of the animal studies to people.
  • That would be a big win for medicine and public health.
  • Vanessa Ward on 11 Jun 10
     
    San Francisco Medical Society discusses the possible relationship between chemical exposure and the obesity epidemic.
Vanessa Ward

PLoS Biology: The Toxic Origins of Disease - 0 views

www.plosbiology.org/...journal.pbio.0050193

obesity endocrine origins of disease DES Blumberg Grun obesogen

shared by Vanessa Ward on 11 Jun 10 - Cached
  • During embryonic development, steroid hormones like estrogen control gene-expression programs to coordinate cell differentiation, growth, organogenesis, and metabolism.
  • “The moment we published something on bisphenol A, the chemical industry went out and hired a number of corporate laboratories to replicate our research. What was stunning about what they did . . . was they hired people who had no idea how to do the work.”
  • “whole-animal toxicological studies,” which look at different endpoints than the more mechanistic studies do, Hughes says. “That doesn't let you look at changes in gene expression, changes in epigenetic control of gene expression.
  • ...5 more annotations...
  • “I can tell you simply by the size of the animal which is DES-exposed and which isn't.”
  • “We found out that brain is a target, bone is a target . . . and now the new target is adipocytes.”
  • When he removed all the soy-derived plant estrogens from the mother's diet, he was astonished to see endogenous estradiol levels in the fetus rise, and the offspring become “horrifically obese.
  • Adding the weak plant estrogens back in the diet suppressed the far more potent endogenous estradiol, he discovered, by inhibiting an enzyme required to make it.
  • Recent evidence suggests that a class of ubiquitous environmental pollutants called organotins can also stimulate adipogenesis and interfere with energy balance
  • Vanessa Ward on 11 Jun 10
     
    This was one of the first articles that I looked in depth at and pretty much read all of. It presents some of the original research done on the effects Bisphenol-A on reproductive development and mammary gland formamation and how in the process led to a noticeable pattern between exposure and weight gain. The study of obesogens is a new field that was in a way accidentally discovered. It has been hypothesized that estrogen causes embryonic cells to develop into fat cells through a process called adipogenesis by chemicals called organotins. New research to support this is addressed in this article.
Vanessa Ward

The Toxic Origins of Disease - 1 views

www.plosbiology.org/...10.1371%2Fjournal.pbio.0050193

shared by Vanessa Ward on 29 May 10 - Cached
  • Vanessa Ward on 29 May 10
     
    This was one of the first articles that I looked in depth at and pretty much read all of. It presents some of the original research done on the effects Bisphenol-A on reproductive development and mammary gland formamation and how in the process led to a noticeable pattern between exposure and weight gain. The study of obesogens is a new field that was in a way accidentally discovered. It has been hypothesized that estrogen causes embryonic cells to develop into fat cells through a process called adipogenesis by chemicals called organotins. New research to support this is addressed in this article.
  • Vanessa Ward on 11 Jun 10
     
    This source is probably the biggest contribution to my paper. I accidentally shared it twice because I couldn't figure out how to edit the tags on this one since it didn't come from my library. I shared it before I figured out how to share the sources from my library to the group, I thought I had to do it separately.
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