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suwhitte

Environmental Health Perspectives - 0 views

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    Environmental Health Perspectives (EHP) is a monthly journal of peer-reviewed research and news published by the U.S. National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services. EHP's mission is to serve as a forum for the discussion of the interrelationships between the environment and human health by publishing in a balanced and objective manner the best peer-reviewed research and most current and credible news of the field. With an impact factor of 6.12, EHP is the top monthly journal in public, environmental, and occupational health and the second-ranked monthly journal in environmental sciences. The environmental health sciences include many fields of study and increasingly comprise a multidisciplinary research area. EHP publishes articles from a wide range of scientific disciplines encompassing basic research; epidemiologic studies; risk assessment; relevant ethical, legal, social, environmental justice, and policy topics; longitudinal human studies; in vitro and in vivo animal research with a clear relationship to human health; and environmental medicine case reports. Because children are uniquely sensitive to their environments, EHP devotes a research section specifically to issues surrounding children's environmental health. Search current issue and archives for journal articles related to your topic.
Matthew Ragan

Open Science Directory - Home - 1 views

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    Access to scientific literature is very important for the scientific work in developing countries . As a result of different projects  a large collection of  e-journals is now available for researchers in developing countries. The number of Open Access Journals is growing steadily as we can see in the Directory of Open Access Journals. Major UNO organizations like WHO, FAO and UNEP have their specific programs for the scientific institutions in low-income countries. Finally a lot of universities, institutes and other organizations are supporting access programs. The most important are INASP, eIFL and eJDS.
suwhitte

Environmental Agents: Endocrine Disruptors - 0 views

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    site maintained by the National Institute of Environmental Health Sciences.
Brandon Knight

ScienceDirect - Journal of Reproductive Immunology : Stress and the female reproductive... - 0 views

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    This journal article talks about the inhibitory effects of stress on the female reproductive system. It gets into the mechanism of the negative feedback with CRH and GnRH.
Anna McLean

Our Stolen Future: New science on the impacts of endocrine disruptors on brain and beha... - 0 views

  • The sex steroids (testosterone, estrogen, etc.) contribute to, among other things, sexual differentiate of brain centers, and thereby, to the development of sexual identity and sexual behaviors
  • A rapidly increasing body of scientific research is revealing mechanisms of action, demonstrating impacts of disrupted development, and exploring links between intelligence, behavior and contamination experienced in the womb. What is emerging from this research is that brain and behavior are likely to be the most sensitive endpoints vulnerable to endocrine disruption. Many synthesized compounds in commercial use today, moreover, can derail neurological development.
  • April 2003. Exposure in the womb to extremely low levels of bisphenol A alters sexual differentiation of the brain and behavior in rats. More...
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  • September 2002. Dutch scientists report that boys exposed prenatally to higher levels of PCBs and dioxin are more likely to show demasculinized play behaviors. Girls and boys exposed to modestly elevated dioxin levels demonstrate more feminized play behaviors. The scientists suggest that that these alterations in play result from endocrine disruption of the development of sex-specific behaviors. More...
  • disturbed sexual differentiation of reproductive behavior, potentiating the expression of feminine sexual behavior and reducing masculine behavior."
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    This document is the web site for the book titled Our Stolen Future. There are numerous sections with "more..." links to full pages on the summarized topic. This is a great tool for my project.
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    Highlighted text indicates areas applicable to my topic.
Liz Richardson

Global assessment of the state-of-the-science of endocrine disruptors - 0 views

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    This is just the index, but the WHO has attempted to pinpoint which hormone compounds are most effective EEDs, and which hormones are most often mimicked. Discusses EED effects on wildlife as well as humans. Criteria for assessment of endocrine disruptors proposed for future studies.
Vanessa Ward

Endocrine Disruptors and the Obesity Epidemic -- Heindel 76 (2): 247 -- Toxicological S... - 1 views

  • "We are faced with the seeming paradox of increased adiposity at both ends of the birth weight spectrum—higher BMI with higher birth weight and increased central obesity with lower birth weight" (Oken and Gillman, 2003). Thus prevention of childhood and adult obesity must start in utero.
  • Indeed, many synthetic chemicals are actually used to increase weight in animals.
  • This article provides fascinating examples of chemicals that have been tested for toxicity by standard tests that resulted in weight gain in the animals at lower doses than those that caused any obvious toxicity.
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  • Chemicals having endocrine-disrupting activity rise to the top of the list as most act via receptors linked to activation of transcriptional activity.
  • In the adult, loss of circulating estrogen due to ovariectomy leads to increased body and adipose tissue weights. Estrogen receptor alpha knockout mice have a significantly increased body fat content, and estrogen decreases the activity of lipoprotein lipase
  • estrogenic endocrine-disrupting chemical bisphenol A at concentrations as low as 2 µg/ml, in the presence of insulin, stimulated differentiation of the 3T3L1 cells into adipocytes
  • he fact that an environmental chemical has the potential to stimulate growth of "preadipocytes" has enormous implications for the area of obesity and its control.
  • Differentiation could be inhibited and more potential fat cells could be formed, as seems to be the case with NP, or differentiation could be stimulated, as appears to be the case with BPA
  • Will these results extrapolate to the in vivo situation in rodents and other animal models?
  • Only time and more research will tell, but the door has been opened by the novel work being highlighted.
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    An article discussing how the area of research of obesity as a result of endocrine disrupting chemical exposure could be a beneficial area for intervention and prevention studies of obesity. This was one of the first articles I found directly addressing how endocrine disrupting chemical exposure can lead to a predisposition to obesity
Anna McLean

ScienceDirect - Brain, Behavior, and Immunity : The potential influence of maternal st... - 0 views

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    Brandon, This may also be of interest to you.
Anna McLean

ScienceDirect - Developmental Brain Research : Early vs. late maternal deprivation dif... - 1 views

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    Brandon, Order this from ILL. This is not the one I told you about it class, I am still searching to relocate that one. This may be of interest, though.
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