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suwhitte

How to maximize your fungicide purchases | Golf Course News | Find Articles at BNET - 0 views

findarticles.com/...ai_n9351774

anti-androgenic epigenetic transgenerational

shared by suwhitte on 03 Jun 10 - Cached
  • suwhitte on 03 Jun 10
     
    Not just limited to fruit production, vinclozolin also used in management of golf courses. Here's how to get the most out of this dangerous fungicide.
Vanessa Ward

PLoS Biology: The Toxic Origins of Disease - 0 views

www.plosbiology.org/...journal.pbio.0050193

obesity endocrine origins of disease DES Blumberg Grun obesogen

shared by Vanessa Ward on 11 Jun 10 - Cached
  • During embryonic development, steroid hormones like estrogen control gene-expression programs to coordinate cell differentiation, growth, organogenesis, and metabolism.
  • “The moment we published something on bisphenol A, the chemical industry went out and hired a number of corporate laboratories to replicate our research. What was stunning about what they did . . . was they hired people who had no idea how to do the work.”
  • “whole-animal toxicological studies,” which look at different endpoints than the more mechanistic studies do, Hughes says. “That doesn't let you look at changes in gene expression, changes in epigenetic control of gene expression.
  • ...5 more annotations...
  • “I can tell you simply by the size of the animal which is DES-exposed and which isn't.”
  • “We found out that brain is a target, bone is a target . . . and now the new target is adipocytes.”
  • When he removed all the soy-derived plant estrogens from the mother's diet, he was astonished to see endogenous estradiol levels in the fetus rise, and the offspring become “horrifically obese.
  • Adding the weak plant estrogens back in the diet suppressed the far more potent endogenous estradiol, he discovered, by inhibiting an enzyme required to make it.
  • Recent evidence suggests that a class of ubiquitous environmental pollutants called organotins can also stimulate adipogenesis and interfere with energy balance
  • Vanessa Ward on 11 Jun 10
     
    This was one of the first articles that I looked in depth at and pretty much read all of. It presents some of the original research done on the effects Bisphenol-A on reproductive development and mammary gland formamation and how in the process led to a noticeable pattern between exposure and weight gain. The study of obesogens is a new field that was in a way accidentally discovered. It has been hypothesized that estrogen causes embryonic cells to develop into fat cells through a process called adipogenesis by chemicals called organotins. New research to support this is addressed in this article.
Vanessa Ward

Prenatal Genistein In Soy Reduces Obesity In Offspring - DukeHealth.org - 8 views

www.dukehealth.org/...9584

genistein phytoestrogen soy endocrine EED

shared by Vanessa Ward on 04 Jun 10 - Cached
  • The agouti methylation consistently occurred throughout several germ layers of embryonic tissue, indicating that genistein acted during early embryonic development. Moreover, the methylation changes persisted into adulthood, providing the first evidence that in utero dietary genistein alters epigenetic gene regulation, coat color, and susceptibility to adult obesity in animals.
  • Liz Richardson on 04 Jun 10
     
    Vanessa - This pertains to both my study and yours. Is lack of soy consumption linked to obesity? Is it worth it to consume soy while pregnant if your child will lose risk of being fat but gain risk of being infertile?
  • Vanessa Ward on 04 Jun 10
     
    This is awesome, thanks Liz.
  • Vanessa Ward on 13 Jun 10
     
    This addresses the controversy of the role of estrogenics and the role they play in predispostion to obesity. DDE studies were positive for resulting in obesity but genistein studies show that in utero exposure results in a lower adult body weight. Both are estrogenics.
Vanessa Ward

Epigenetics, Evolution, Endocrine Disruption, Health, and Disease -- Crews and McLachla... - 1 views

endo.endojournals.org/...s4

shared by Vanessa Ward on 22 May 10 - Cached
  • Endocrine-disrupting chemicals (EDCs) in the environment have been linked to human health and disease. This is particularly evident in compounds that mimic the effects of estrogens.
  • information recently uncovered, regarding mechanisms of endocrine and environmental signaling, to explore the role of the environment in health and disease.
  • Vanessa Ward on 22 May 10
     
    This a good article that gives a general overview of EDC's and the role they play in the compromise of physical and mental health. One particularly interesting thing is how a discussion of EDC's and evolution is presented.
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