Group items tagged

Some interesting ideas for our crowdsourcing game in here.

A group of proteins that act as the body's built-in line of defense against invading bacteria use a molecular trick to induce bacteria to destroy themselves...

Here, we show that fluorescent proteins4, 5 in cells are a viable gain medium for optical amplification, and report the first successful realization of biological cell lasers based on green fluorescent protein (GFP).

Science In nature, proteins sweep up nanoparticles

Apparently, I becomes possible to create proteins from scratch already. Things become interesting...

Galactic Cosmic Radiation consisting of high-energy, high-charged (HZE) particles poses a significant threat to future astronauts in deep space. Aside from cancer, concerns have been raised about late degenerative risks, including effects on the brain. In this study we examined the effects of 56Fe particle irradiation in an APP/PS1 mouse model of Alzheimer's disease (AD). We demonstrated 6 months after exposure to 10 and 100 cGy 56Fe radiation at 1 GeV/µ, that APP/PS1 mice show decreased cognitive abilities measured by contextual fear conditioning and novel object recognition tests. Furthermore, in male mice we saw acceleration of Aβ plaque pathology using Congo red and 6E10 staining, which was further confirmed by ELISA measures of Aβ isoforms. Increases were not due to higher levels of amyloid precursor protein (APP) or increased cleavage as measured by levels of the β C-terminal fragment of APP. Additionally, we saw no change in microglial activation levels judging by CD68 and Iba-1 immunoreactivities in and around Aβ plaques or insulin degrading enzyme, which has been shown to degrade Aβ. However, immunohistochemical analysis of ICAM-1 showed evidence of endothelial activation after 100 cGy irradiation in male mice, suggesting possible alterations in Aβ trafficking through the blood brain barrier as a possible cause of plaque increase. Overall, our results show for the first time that HZE particle radiation can increase Aβ plaque pathology in an APP/PS1 mouse model of AD.

Avoiding carbohydrates might make you thinner, but if you want to live longer and healthier, it might not be the smartest thing to do...

Single molecule detection: Might this be of interest for detecting proteins or other stuff on Mars etc.?

Protein Folding solved by AI?

Impressive ...

A "four-wheel drive car" less than one billionth the length of an average SUV has been built and operated by researchers in the Netherlands and Switzerland.

"Molecular machines are common in nature. Motor proteins, for example, can move along a surface to transport molecular-sized cargo and are often used to build structures within living cells. " reminds me of the fantastic movie on what happens inside a cell ...

some biomimicry used in energy systems... maybe it sparks some ideas

not much new that has not been shared here before ... BUT: we have done relativley little on any of them. for good reasons?? don't know - maybe time to look into some of these again more closely Energy Efficiency( Termite mounds inspired regulated airflow for temperature control of large structures, preventing wasteful air conditioning and saving 10% energy.[1] Whale fins shapes informed the design of new-age wind turbine blades, with bumps/tubercles reducing drag by 30% and boosting power by 20%.[2][3][4] Stingray motion has motivated studies on this type of low-effort flapping glide, which takes advantage of the leading edge vortex, for new-age underwater robots and submarines.[5][6] Studies of microstructures found on shark skin that decrease drag and prevent accumulation of algae, barnacles, and mussels attached to their body have led to "anti-biofouling" technologies meant to address the 15% of marine vessel fuel use due to drag.[7][8][9][10] Energy Generation( Passive heliotropism exhibited by sunflowers has inspired research on a liquid crystalline elastomer and carbon nanotube system that improves the efficiency of solar panels by 10%, without using GPS and active repositioning panels to track the sun.[11][12][13] Mimicking the fluid dynamics principles utilized by schools of fish could help to optimize the arrangement of individual wind turbines in wind farms.[14] The nanoscale anti-reflection structures found on certain butterfly wings has led to a model to effectively harness solar energy.[15][16][17] Energy Storage( Inspired by the sunlight-to-energy conversion in plants, researchers are utilizing a protein in spinach to create a sort of photovoltaic cell that generates hydrogen from water (i.e. hydrogen fuel cell).[18][19] Utilizing a property of genetically-engineered viruses, specifically their ability to recognize and bind to certain materials (carbon nanotubes in this case), researchers have developed virus-based "scaffolds" that

Luca Turin presents a theory according to which the sense of smell is aroused by molecular vibrations instead of the shape-based compatibility with receivers on the proteins.

Does this have implications for AI algorithms??

I was actually thinking exactly about this question during my bike ride this morning. I am surprised that some codons would need to have a double meaning though because there is already a surplus of codons to translate into just 20-22 proteins (depending on organism). So there should be about 44 codons left to prevent translation errors and in addition regulate gene expression. If - as the article suggests - a single codon can take a dual role, does it so in different situations (needing some other regulator do discern those)? Or does it just perform two functions that always need to happen simultaneously? I tried to learn more from the underlying paper: https://www.sciencemag.org/content/342/6164/1367.full.pdf All I got from that was a headache. :-\

Probably both. Likely a consequence of energy preservation during translation. If you can do the same thing with less genes you save up on the effort required to reproduce. Also I suspect it has something to do with modularity. It makes sense that the gene regulating for "foot" cells also trigger the genes that generate "toe" cells for example. No point in having an extra if statement.

At the link below you find additional information about the projects: Education: Ten weeks to save the world http://www.nature.com/news/2010/100915/full/467266a.html

well, most good ideas probably take only a second to be formulated, it's the details that take years :-)

I do not think the point of the SU is to formulate new ideas (infact there is nothing new in the projects chosen). Their mission is to build and maintain a network of contacts among who they believe will be the 'future leaders' of space ... very similar to our beloved ISU.

In this article the authors describe an improvement of their optical microscope techniques for which some of the received a Nobel prize in the past. They achieve resolutions far beyond the optical diffraction limit which is supposed to limit detail resolution due to quantum-mechanical effects. Their techniques include structured illuminiation (producing interference patterns), switchable fluorescent markers as well as multi-frame super resolution enhancement. Authors are able to take a single image in about 0.3 seconds which allows the study of protein processes in the cell: http://spon.de/vgTb7 . Although it is hard to imagine the application of many of these techniques for telescopes (except for super resolution), I am wondering if any of this could help building telescopes with increased optical power or reduced weight. Any ideas..?

While most humans are right-handed, our proteins are made up of lefty molecules. In the same way your left and right hands mirror one another, molecules can assemble in two reflected structures. Life prefers the left-handed version, which is puzzling since both mirrored types form equally in the laboratory.

link to the paper: http://dx.doi.org/10.1038/nsmb.2119 additional info at: http://fold.it/portal/