Group items tagged

"scientists at Harvard University say they've modified the CRISPR method so it can be used to effectively reverse mutations involving changes in one letter of the genetic code. That's important because two-thirds of genetic illness in humans involve mutations where there's a change in a single letter."

"Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9" http://www.nature.com/nature/journal/vaop/ncurrent/full/nature17664.html?WT.ec_id=NATURE-20160428&spMailingID=51249830&spUserID=MTEzODM0NjYzMzgS1&spJobID=903461217&spReportId=OTAzNDYxMjE3S0 As posted here previously, the number and importance of CRISPR is growing steadily, but still plenty of work to make it a reliable tool. Maybe, next work for the Molecular Engineering RF?

The best post of Slashdot: "Genetic Algorithms are like the AI equivalent of text editors... everybody has spent a weekend writing one at some point."

An incresingly popular scientific enome re-writting tool. Might prevent future generations from being born with some types of disorders or disabilities! Also, for fun, can be looked at one step closer to having a real wolverine..

"Chinese team uses CRISPR to genetically modify human embryo" http://medicalxpress.com/news/2016-04-chinese-team-crispr-genetically-human.html?utm_source=nwletter&utm_medium=email&utm_campaign=weekly-nwletter

We made it to Slashdot's frontpage !!! :)

Congratulations, gentlemen!

Does this have implications for AI algorithms??

I was actually thinking exactly about this question during my bike ride this morning. I am surprised that some codons would need to have a double meaning though because there is already a surplus of codons to translate into just 20-22 proteins (depending on organism). So there should be about 44 codons left to prevent translation errors and in addition regulate gene expression. If - as the article suggests - a single codon can take a dual role, does it so in different situations (needing some other regulator do discern those)? Or does it just perform two functions that always need to happen simultaneously? I tried to learn more from the underlying paper: https://www.sciencemag.org/content/342/6164/1367.full.pdf All I got from that was a headache. :-\

Probably both. Likely a consequence of energy preservation during translation. If you can do the same thing with less genes you save up on the effort required to reproduce. Also I suspect it has something to do with modularity. It makes sense that the gene regulating for "foot" cells also trigger the genes that generate "toe" cells for example. No point in having an extra if statement.

While the new bacteria is pretty much useless, it would be interesting to see how base 3 genetic programming would turn out.

Scientific and speculative articles about the future of human evolution regarding to artificial intelligence, genetic engineering, transhumanism, nanotechnology, space colonization, time travel, life extension and human enhancement

Exciting new technique in genetic engineering

Might be a useful reference for PyGMO-related works.

By just getting a DNA footprint of a person scientists (and soon police) can produce an image of the person's face. Check out the pictures!

should try it the other way around, deduce the DNA from facial features. That would be even cooler.

Well actually, they did something like that as they searched for common DNA patterns in people that had similar facial features. With a large enough dataset that could provide already 24 DNA tracers that could used reliably for prediction. Imagine if you had even more data available, who needs a model then... just let the NN do it :)

Engineering and improving great tits so they can better withstand climate change. By selectively breeding and genetically engineering the birds scientists try to keep the time when the birds produce offspring in sync with the changing availability of food sources in spring (mainly grubs).

Looks like the genetic evidence for the interbreding of homo sapiens and homo neanderthalensis becomes significant.

"Humans and Neanderthals interbred" - isn't that a bit weird since we call the result of the interbreeding "Humans" as well? This is a bit like saying "Ligers and Tigers interbred".

"Using light and a little genetic engineering -- optogenetics -- Gero Miesenboeck has developed a way to control how living nerve cells work, and advanced understanding of how the brain controls behavior."

This is related to the "Verified Software" item in NewScientist's list of ideas that will change science. At the link below you'll find the text of the patents being auctioned: http://icapoceantomo.com/item-for-sale/exclusive-license-related-improved-methodology-formally-developing-control-systems :) Patent #7,627,538 ("Swarm autonomic agents with self-destruct capability") makes for quite an interesting read: "This invention relates generally to artificial intelligence and, more particularly, to architecture for collective interactions between autonomous entities." "In some embodiments, an evolvable synthetic neural system is operably coupled to one or more evolvable synthetic neural systems in a hierarchy." "In yet another aspect, an autonomous nanotechnology swarm may comprise a plurality of workers composed of self-similar autonomic components that are arranged to perform individual tasks in furtherance of a desired objective." "In still yet another aspect, a process to construct an environment to satisfy increasingly demanding external requirements may include instantiating an embryonic evolvable neural interface and evolving the embryonic evolvable neural interface towards complex complete connectivity." "In some embodiments, NBF 500 also includes genetic algorithms (GA) 504 at each interface between autonomic components. The GAs 504 may modify the intra-ENI 202 to satisfy requirements of the SALs 502 during learning, task execution or impairment of other subsystems."

Researchers led by Ronald A. DePinho (above), a Harvard Medical School professor of genetics, say their work shows for the first time a dramatic reversal of many aspects of age-related degeneration in mice, a milestone in aging science achieved by engineering mice with a controllable telomerase gene. T

I would not yet volunteer ....

Genetic algorithms are a competitive alternative for training deep neural networks for reinforcement learning. For paper see: https://arxiv.org/pdf/1712.06567.pdf

Interesting pointers in this one! I would like to explore neuroevolution as well, although it seems extremely resource-demanding?

Not necessarily, I think it can be made to be much faster hybridizing it with backprop and Taylor maps. Its one ideas in the closet we still have not explored (Differential Intelligence: accelerating neuroevolution).

Scientists have developed artificial genetic molecules with different structural backbones (XNA, TNA) and/ or a different nucleic acid alphabet. (from April 2012)

The spreadsheet software Microsoft Excel, when used with default settings, is known to convert gene names to dates and floating-point numbers. A programmatic scan of leading genomics journals reveals that approximately one-fifth of papers with supplementary Excel gene lists contain erroneous gene name conversions. The reason why you shouldn't use Excel (or Numbers or OpenOffice or ...) without knowing what it actually really does!

It's proven, sleepiness is genetic.

Why it is written 0 views if I read it ?!