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Galactic Cosmic Radiation consisting of high-energy, high-charged (HZE) particles poses a significant threat to future astronauts in deep space. Aside from cancer, concerns have been raised about late degenerative risks, including effects on the brain. In this study we examined the effects of 56Fe particle irradiation in an APP/PS1 mouse model of Alzheimer's disease (AD). We demonstrated 6 months after exposure to 10 and 100 cGy 56Fe radiation at 1 GeV/µ, that APP/PS1 mice show decreased cognitive abilities measured by contextual fear conditioning and novel object recognition tests. Furthermore, in male mice we saw acceleration of Aβ plaque pathology using Congo red and 6E10 staining, which was further confirmed by ELISA measures of Aβ isoforms. Increases were not due to higher levels of amyloid precursor protein (APP) or increased cleavage as measured by levels of the β C-terminal fragment of APP. Additionally, we saw no change in microglial activation levels judging by CD68 and Iba-1 immunoreactivities in and around Aβ plaques or insulin degrading enzyme, which has been shown to degrade Aβ. However, immunohistochemical analysis of ICAM-1 showed evidence of endothelial activation after 100 cGy irradiation in male mice, suggesting possible alterations in Aβ trafficking through the blood brain barrier as a possible cause of plaque increase. Overall, our results show for the first time that HZE particle radiation can increase Aβ plaque pathology in an APP/PS1 mouse model of AD.

Researchers led by Ronald A. DePinho (above), a Harvard Medical School professor of genetics, say their work shows for the first time a dramatic reversal of many aspects of age-related degeneration in mice, a milestone in aging science achieved by engineering mice with a controllable telomerase gene. T

I would not yet volunteer ....

Asimov's Foundation meets ACT's Tipping Point Prediction?

still, some interesting thoughts in there ... "Then you have the 50-year cycles of violence. Turchin describes these as the building up and then the release of pressure. Each time, social inequality creeps up over the decades, then reaches a breaking point. Reforms are made, but over time, those reforms are reversed, leading back to a state of increasing social inequality. The graph above shows how regular these spikes are - though there's one missing in the early 19th century, which Turchin attributes to the relative prosperity that characterized the time. He also notes that the severity of the spikes can vary depending on how governments respond to the problem. Turchin says that the United States was in a pre-revolutionary state in the 1910s, but there was a steep drop-off in violence after the 1920s because of the progressive era. The governing class made decisions to reign in corporations and allowed workers to air grievances. These policies reduced the pressure, he says, and prevented revolution. The United Kingdom was also able to avoid revolution through reforms in the 19th century, according to Turchin. But the most common way for these things to resolve themselves is through violence. Turchin takes pains to emphasize that the cycles are not the result of iron-clad rules of history, but of feedback loops - just like in ecology. "In a predator-prey cycle, such as mice and weasels or hares and lynx, the reason why populations go through periodic booms and busts has nothing to do with any external clocks," he writes. "As mice become abundant, weasels breed like crazy and multiply. Then they eat down most of the mice and starve to death themselves, at which point the few surviving mice begin breeding like crazy and the cycle repeats." There are competing theories as well. A group of researchers at the New England Complex Systems Institute - who practice a discipline called econophysics - have built their own model of political violence and

It's not the scientific activity described in the article that is uninteresting, on the contrary! But the way it is described is just a bad joke. Once again the results itself are seemingly not sexy enough and thus something is sold as the big revolution, though it's just the application of the oldest scientific principles in a slightly different way than used before.

It's proven, sleepiness is genetic.

Why it is written 0 views if I read it ?!

a bit of an overstatement. the trial is only at mice stage, but nevertheless interesting for its future application.

any new findings in there?

isn't it strange that one single gene mutation can enable or disable such a complex behavioural pattern? anything to take advantage of in our gate study (Guido?)

The goal is to better understand how memory works to help for example against dementia, depression, stress.. but as we all know it would be great to learn how to fly a helicopter in 5 seconds as well.

... or to make a first real inception ;)

By giving old mice young fresh blood, aging in their brains and hearts can be "reversed" by triggering the mouse's stem cells.

Already published in A.D. 1489...

By reactivating a dormant gene called Lin28a, which is active in embryonic stem cells, researchers were able to regrow hair and repair cartilage, bone, skin and other soft tissues in a mouse model.

regrow hair???!!!??? :-)

Loosely related to an old ACT project on optical flow (if I remember correctly but even if not still an interesting read I think): "At first glance, the eyes of mammals and those of insects do not seem to have much in common. However, a comparison of the neural circuits for detecting motion shows surprising parallels between flies and mice. Scientists have learned a lot about the visual perception of both animals in recent years."

Nice approach to generate healthy skin and to patch parts or to replace the overall human skin. Next step - clinical studies.

Exercise can enhance the development of new brain cells in the adult brain, a process called adult neurogenesis. These newborn brain cells play an important role in learning and memory. A new study has determined that mice that spent time running on wheels not only developed twice the normal number of new neurons, but also showed an increased ability to distinguish new objects from familiar objects.

wow ... time to start running again ...