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Sarah Muncy

A Breakthrough Against Leukemia Using Altered T-Cells - NYTimes.com - 1 views

www.nytimes.com/...mia-using-altered-t-cells.html

virology cancer immunology microbiology

shared by Sarah Muncy on 10 Dec 12 - No Cached
  • To perform the treatment, doctors remove millions of the patient’s T-cells — a type of white blood cell — and insert new genes that enable the T-cells to kill cancer cells. The technique employs a disabled form of H.I.V. because it is very good at carrying genetic material into T-cells. The new genes program the T-cells to attack B-cells, a normal part of the immune system that turn malignant in leukemia.
  • The T-cells home in on a protein called CD-19 that is found on the surface of most B-cells
  • cytokine-release syndrome, or cytokine storm
  • ...5 more annotations...
  • Dr. June knew that a drug could lower IL-6
  • tocilizumab
  • the altered T-cells persist in the bloodstream
  • The researchers are not entirely sure why the treatment works, or why it sometimes fails.
  • It is not clear whether a patient’s body needs the altered T-cells forever. The cells do have a drawback: they destroy healthy B-cells as well as cancerous ones, leaving patients vulnerable to certain types of infections, so Emma and the other patients need regular treatments with immune globulins to prevent illness.
    • Sarah Muncy
      Sarah Muncy on 12 Dec 12
       
      I was wondering when they'd get to the consequences of killing off the B cells- that's huge.
  • Sarah Muncy on 12 Dec 12
     
    That's so funny- I just saw the update email and Dr. Finnerty also saw this topic (a different article) and posted it, too!)
Sarah Muncy

The HIV Virus: A Possible Cure for Leukemia? | Yahoo! Health - 0 views

health.yahoo.net/...v-virus-possible-cure-leukemia

shared by Sarah Muncy on 12 Dec 12 - No Cached
  • It's important to note that the T-cells are removed from the patient before being bioengineered with the HIV virus
    • Sarah Muncy
      Sarah Muncy on 12 Dec 12
       
      Why is it important to note that the disabled virus isn't injected into the patient? It's function isn't like chemotherapy at all- why even make the comparison?
    • Sarah Muncy
      Sarah Muncy on 12 Dec 12
       
      Is there some reason they use T cells only? Are they trying to target T cells, but not dendritic cells or macrophages?
  • therapies that involve the reprogramming of a patient’s immune system, may also eventually be used to fight cancerous breast and prostate tumors.
    • Sarah Muncy
      Sarah Muncy on 12 Dec 12
       
      What about lupus, or even allergies for that matter?
  • ...1 more annotation...
  • Within hours
    • Sarah Muncy
      Sarah Muncy on 12 Dec 12
       
      Within hours?!
  • Sarah Muncy on 12 Dec 12
     
    Whoa. If someone is doing HIV- this may be helpful. The virus is being used as a delivery device for genetics to reprogram lymphocytes. They're like biological nanorobots.
Casey Finnerty

mBio - September/October 2012, 3 (5) - 0 views

mbio.asm.org/5.toc

virology influenza H5N1

shared by Casey Finnerty on 04 Dec 12 - No Cached
  • Casey Finnerty on 04 Dec 12
     
    This issue of mBio has several updates and opinion pieces on the H5N1 research moratorium.
Casey Finnerty

Dengue Research Opportunities in the Americas - 0 views

jid.oxfordjournals.org/...1121.full

Dengue virus virology

shared by Casey Finnerty on 29 Nov 12 - No Cached
  • Casey Finnerty on 29 Nov 12
     
    Very nice updated review on Dengue virus
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