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Casey Finnerty

HHMI's BioInteractive - Infectious Diseases Lecture Series - 2 views

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    This page has links to all the HHMI Holiday Lectures on infectious disease topics.Currently these include: "2000 and Beyond: Confronting the Microbe Menace", "AIDS: Evolution of an Epidemic", and "Viral Outbreak: The Science of Emerging Disease".
Sarah Muncy

High levels of genetic variation within Helicover... [Arch Virol. 2012] - PubMed - NCBI - 0 views

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    Is it that the virus itself has a great deal of genetic diverisity, or is it somehow an emergent property with it and the host organism? Insects are arguably the most diverse organisms on earth, doesn't it seem reasonable to expect baculoviruses to be equally diverse? Even if they're simply diverse because they've evolved (or whatever terms apply to these abiotic "Creatures") together, each one-upping each other as natural selection has operated- it's pretty cool.
Casey Finnerty

Calls/Webinars|Clinician Outreach and Communication Activity (COCA) - 0 views

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    I *highly* recommend you check out the CDC COCA calls if you are interested in medicine and infectious disease. Today's call on focal limb paralysis co-incident with the current outbreak of EV-D68 was fascinating. You may find my notes on it at this link: https://www.evernote.com/shard/s7/sh/01e57d8c-bc3f-4e86-85c6-476117fa5731/80a13752cdcfd28a5a4224d1c9df882f
Casey Finnerty

http://health.mo.gov/emergencies/ert/alertsadvisories/pdf/HA82914.pdf - 0 views

  • 2approved by theFood and Drug Administration for use in clinical settings ( LuminexxTAGRVP, Idaho Technologies FilmArray Respiratory Panel). But, these systems use broadly reactive primers that amplify RNA from either human rhinoviruses (HRVs) or enteroviruses, and results are reported as "entero-rhinovirus" or "human rhinovirus/
  • Recently, a pediatric hospital in Kansas City,Missouri has experienced over 300 cases of respiratory illnesses in their facility. Approximately 15% of those illnesses have resulted in children being placed in an intensive care unit.
laceemarie

Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets - 12 views

  • The MBCS in HA can be cleaved by ubiquitously expressed host proteases; this cleavage facilitates systemic virus replication and results in mortality of up to 100% in poultry (9, 10).
  • Although limited A/H5N1 virus transmission between persons in close contact has been reported, sustained human-to-human transmission of HPAI A/H5N1 virus has not been detected (13–15).
    • Casey Finnerty
       
      Could this not be happening?
  • The viruses that caused the major pandemics of the past century emerged upon reassortment (that is, genetic mixing) of animal and human influenza viruses (22).
    • Casey Finnerty
       
      How many pandemics are they talking about? Put another way, for how many pandemics in human history, do we have the virus on hand to analyze?
  • ...2 more annotations...
  • Influenza A viruses show pronounced genetic variation of the surface glycoproteins HA and NA
    • slgoogin8981
       
      Why is this an important site for variation?
    • laceemarie
       
      To be able to bind to a variety of different cells?
  • the factors that determine airborne transmission of influenza viruses among mammals, a trait necessary for a virus to become pandemic, have remained largely unknown (18–21)
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    This is the H5N1 mammal transmissibility paper from the Fouchier group.
Casey Finnerty

New Ebola Case Emerges in Setback for Sierra Leone - The New York Times - 0 views

  • Already 10 other flare-ups have taken place in areas where the spread of Ebola was thought to have ended, raising new questions about WHO procedures in assessing whether an epidemic was really over.
  • the woman was not buried safely because local health workers had not identified her as a suspected Ebola case. That raises the possibility there could be a wider Ebola outbreak.
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