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Contents contributed and discussions participated by Katelyn Madigan

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Katelyn Madigan

Holographic microscopy: Peering into living cells -- with neither dye nor fluophore - 0 views

www.sciencedaily.com/...130207172205.htm

Holographic Microscopy

shared by Katelyn Madigan on 08 Feb 13 - No Cached
  • incredibly precise resolution of less than 100 nanometers, 1000 times smaller than the diameter of a human hair.
  • observe in real time the reaction of a cell that is subjected to any kind of stimulus
  • low-intensity laser, the influence of the light or heat on the cell is minimal,
  • ...1 more annotation...
  • can be virtually "sliced" to expose its internal elements, such as the nucleus, genetic material and organelles.
  • Katelyn Madigan on 08 Feb 13
     
    Observe living tissues at the nanoscale
Katelyn Madigan

'Quadruple helix' DNA discovered in human cells - 0 views

www.sciencedaily.com/...130120150033.htm

DNA quadruple helix

shared by Katelyn Madigan on 07 Feb 13 - No Cached
  • our-stranded 'quadruple helix' DNA structures -- known as G-quadruplexes
  • rich in the building block guanine
  • over 10 years investigation by scientists to show these complex structures in vivo -- in living human cells
  • ...2 more annotations...
  • quadruplexes are more likely to occur in genes of cells that are rapidly dividing, such as cancer cells.
  • quadruplex DNA is found fairly consistently throughout the genome of human cells and their division cycles
  • Katelyn Madigan on 07 Feb 13
     
    A better understanding of DNA structure, as well as other factors at the molecular level, have tremendous clinical implications. A personalized inhibitory mechanism for proliferating cancer cells looks like a promising approach for cancer treatments.
Katelyn Madigan

Tomorrow's life-saving medications may currently be living at the bottom of the sea - 1 views

www.sciencedaily.com/...130129130949.htm

medications sea

shared by Katelyn Madigan on 30 Jan 13 - No Cached
  • new antibiotics to keep these diseases at bay.
  • Bacteria that live in harmony with animals are a promising source. "
  • bacteria carried by cone snails produce a chemical that is neuroactive,
  • ...2 more annotations...
  • chemicals have promise for treatment of pain
  • "Mollusks with external shells, like the cone snail, were previously overlooked in the search for new antibiotics and other medications
  • Katelyn Madigan on 30 Jan 13
     
    Scientists return to previously overlooked sources for new antibiotics and other medications - really portrays the prevalence of antibiotic-resistant microbes.
Katelyn Madigan

Research may lead to new strategies against sepsis - 0 views

www.sciencedaily.com/...130125142201.htm

Sepsis

shared by Katelyn Madigan on 27 Jan 13 - No Cached
    • Katelyn Madigan
      Katelyn Madigan on 27 Jan 13
       
      I have read other articles where the fatality for sepsis has ranged between 25-50%, so it seems like an improvement to have antibiotics currently at 25%. This is still way too high to be acceptable.
  • This cell migration further stimulates the immune system, increasing the release of other signaling molecules and factors. But how this occurs hasn't been completely understood."
  • Eliminating STIM1 or blocking the channel both reduced the permeability of the lungs' blood vessels and lessened lung edema
    • Katelyn Madigan
      Katelyn Madigan on 27 Jan 13
       
      Huge issue - especially in older population
  • ...1 more annotation...
  • design new molecules that target the activation of the STIM protein.
Katelyn Madigan

Novel approaches needed to end growing scourge of 'superbugs' - 1 views

www.sciencedaily.com/...130123195258.htm

Superbugs

shared by Katelyn Madigan on 25 Jan 13 - No Cached
    • Katelyn Madigan
      Katelyn Madigan on 25 Jan 13
       
      How common are intestinal infections compared to the more well-known UTIs?
  • development of new antibiotics to treat these infections is plummeting
    • Katelyn Madigan
      Katelyn Madigan on 25 Jan 13
       
      Unable to keep up with the rapidly mutating strains?
  • ...6 more annotations...
  • greater disinfection and less usage of invasive materials than can transmit antibiotic-resistant bacteria into the body
  • moderate the inflammatory response to infection or that limit microbial growth by blocking access to host resources without attempting to kill microbes.
    • Katelyn Madigan
      Katelyn Madigan on 25 Jan 13
       
      Are there multiple ways to provide resistance to the host cell? Would this be done only after an infection, so as to just limit the damage done?
  • If we want a long-term solution, the answer is not incremental tweaking of these policies and processes. Novel approaches, based on a reconceptualization of the nature of resistance, disease, and prevention, are needed.
    • Katelyn Madigan
      Katelyn Madigan on 25 Jan 13
       
      Well stated.
  • infect more than 2 million Americans every year and kill more than 100,000 annually,
Katelyn Madigan

Viral reactivation a likely link between stress and heart disease - 1 views

www.sciencedaily.com/...130122162331.htm

Virus Stress Heart Disease

shared by Katelyn Madigan on 24 Jan 13 - No Cached
    • Katelyn Madigan
      Katelyn Madigan on 24 Jan 13
       
      It is important not to exaggerate your findings, so I think it is good that they are honest with areas of the research that are still not definitive.
  • enhanced levels of proinflammatory proteins in the blood of patients with acute coronary events and detectable levels of the EBV-related protein
  • looked for antibodies against a protein that can be produced even when only partial or incomplete reactivation of Epstein-Barr EBV occurs
  • ...4 more annotations...
  • having more of one of these proteins in the blood was linked to the presence of antibodies that signal a latent Epstein-Barr virus
  • EBV, a human herpes virus that causes infectious mononucleosis and several different types of tumors
  • Stress is a known predictor of reactivation of EBV, meaning virus reactivation could be a mechanism by which stress leads to chronic inflammation and eventually cardiovascular diseases.
  • viral proteins can induce inflammation, affecting the lining of blood vessels, so that inflammation is in the right place to function as a significant risk factor for heart disease
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