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Abdirizak Abdi

New Method Developed To Kill Pathogenic Bacteria Without Antiobiotics Or Chemicals - 0 views

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    Researchers have developed a new method to eliminate deadly pathogenic bacteria in food products and packaging, without the need for antibiotics or chemicals. The method can kill various types of pathogenic bacteria, including Listeria, which is among most common cause of food-borne illness. The team of engineers managed to successfully attach cell lytic enzymes to silica nano particles, which are entirely safe to be used with food products, and created a coating that could selectively kill Listeria, when it gets contact with the bacteria, without affecting other chemicals or bacteria present. The process takes few mins and can tackle listeria even in high concentration.The lytic enzymes could be attached to starch nanoparticles that are typically used for food packaging.
Elijah Velasquez

A viral grappling hook: Flu virus attacks like a pirate boarding party - 1 views

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    The flu virus carries about 300 to 400 of these hooks and virologists had known that several are needed to fuse the membranes. 4 hooks has recently been identified as the number of hooks required to pull the two membranes together. Without the attachment of 4 hooks the virus is vulnerable to inhibitors which will prevent fusion.
Tyrell Varner

How antibodies neutralize mosquito-borne virus - 1 views

  • The findings show the precise structure of the virus-like particle bound to a key part of the antibodies, called the antigen binding fragment, or Fab, which attaches to the heterodimers making up the virus's outer shell. The analyses showed that the antibodies stabilize the viral surface, hindering fusion to the host cell and likely neutralizing infection.
  • "This is the first time the structure of an alphavirus has been examined in this detail,"
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    This could help researchers find a vaccine for this disease, which has symptoms closely related to Dengue Fever.
saraeberhardt

Nanosponges used to soak up toxins in the bloodstream - 0 views

  • the tiny sponges mimic red blood cells, and are able to soak up lethal toxins – including snake venom and bacteria – from the bloodstream.
  • The nanosponges are made up of a biocompatible polymer core, which is coated with segments of the host’s red blood cell membranes.
  • each nanosponge is 3,000 times smaller than a red blood cell
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  • So many of the nanosponges are injected that they end up actually outnumbering the real red blood cells in the bloodstream. This results in the majority of the toxins attaching themselves to the sponges, leaving most of the blood cells alone.
  • The project was led by Prof. Liangfang Zhang, and described in a paper recently published in the journal Nature Nanotechnology
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    As I'm working on my presentation, I came across this article. I thought it was very interesting considering what I'm presenting on releases two very potent toxins into the bloodstream and ultimately leads to death. 
Sean Hogan

Fighting bacteria with new genre of antibodies - 0 views

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    Colloid antibodies which are packing with a killing agent have been designed to recognize the specific shape of bacteria. After attachment of the colloid the killing agent that resides within is released.
Nellie Bogunovic

Hospitals See Surge of Superbug-Fighting Products - 0 views

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    Reminds me of when Dr. Finnerty told us about the sinks they had at Cornell that weren't attached to the walls so bacteria wouldn't accumulate in the seam between the sink and wall!
Abdirizak Abdi

Using 'Bacteria-Eaters' to Prevent Infections On Medical Implant Materials - 0 views

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    They describe attachment of phages to the surfaces of materials like those used in implanted medical devices, and evidence that the phages remain active, killing E. coli and Staphylococcus aureus. Those bacteria cause the most common hospital-acquired infections.
Alletia DeMartino

Pseudomonas aeruginosa Turns Protein Into a Virulence Factor in One Easy Step - 0 views

  • To infect its host, the respiratory pathogen Pseudomonas aeruginosa takes an ordinary protein usually involved in making other proteins and adds three small molecules to turn it into a key for gaining access to human cells.
  • P. aeruginosa, one of the most common causes of hospital-acquired pneumonia.
  • P. aeruginosa mostly uses this protein called elongation factor-Tu (EF-Tu) inside the cel
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  • but she and her collaborators have learned that as a virulence factor, it could represent a vulnerability for the bacterium
  • EF-Tu is presumed to be an essential protein, and it's performing these moonlighting functions as well. If we figured out how it was doing that, we could devise strategies to inhibit it," says Goldberg.
  • acquired pneumonia and is the leading cause of death among critically ill patients whose airways have been damaged by ventilation, trauma, or other infections.
  • P. aeruginosa takes
  • the protein EF-Tu, which was generally thought to exist only inside the cell, and decorates the exterior of the cell with it, but in a modified form.
  • EF-Tu is modified somehow to mimic ChoP, allowing P. aeruginosa to enjoy the benefits of ChoP.
  • , ChoP carries out a crucial step for setting up an infection for a number of different types of respiratory pathogens.
  • Using a host of techniques, including mass spectrometry, site directed mutagenesis of key residues in the protein, and genetic loss of function/gain of function studies, they found that P. aeruginosa only makes small changes to EF-Tu to get it to mimic this powerful ligand. P. aeruginosa transfers three methyl groups to a lysine on EF-Tu, giving it a structure similar to ChoP and allowing it to fit in the PAFR receptor in the way ChoP does.
  • "It allows [P. aeruginosa] to adhere to the cells and invade,"
  • "Its interaction with humans is accidental. It's an opportunist. The fact that it has this novel modification on this protein that is inherent in the bacterium that enables it to attach and persist and cause disease is exciting,"
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    Interesting!! however, very scary. It just keeps modifying itself and being more virulent. what's next?!
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