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Tyrell Varner

How antibodies neutralize mosquito-borne virus - 1 views

www.sciencedaily.com/...130402125044.htm

virus antibodies

shared by Tyrell Varner on 02 Apr 13 - No Cached
  • The findings show the precise structure of the virus-like particle bound to a key part of the antibodies, called the antigen binding fragment, or Fab, which attaches to the heterodimers making up the virus's outer shell. The analyses showed that the antibodies stabilize the viral surface, hindering fusion to the host cell and likely neutralizing infection.
  • "This is the first time the structure of an alphavirus has been examined in this detail,"
  • Tyrell Varner on 02 Apr 13
     
    This could help researchers find a vaccine for this disease, which has symptoms closely related to Dengue Fever.
Tiffany Arcand

Antibody transforms stem cells directly into brain cells - 0 views

www.sciencedaily.com/...130422154756.htm

shared by Tiffany Arcand on 23 Apr 13 - No Cached
  • Tiffany Arcand on 23 Apr 13
     
    Scientists have turned stem cells into brain cells using antibodies, which turned out to be simpler than using conventional methods. In the future, this could be a very effective method for treating neurological injuries, and would nearly eliminate any chance for rejection by the patient.
Sean Hogan

Fighting bacteria with new genre of antibodies - 0 views

www.sciencedaily.com/...130424112314.htm

shared by Sean Hogan on 05 May 13 - No Cached
  • Sean Hogan on 05 May 13
     
    Colloid antibodies which are packing with a killing agent have been designed to recognize the specific shape of bacteria. After attachment of the colloid the killing agent that resides within is released.
Katelyn Madigan

Viral reactivation a likely link between stress and heart disease - 1 views

www.sciencedaily.com/...130122162331.htm

Virus Stress Heart Disease

shared by Katelyn Madigan on 24 Jan 13 - No Cached
    • Katelyn Madigan
      Katelyn Madigan on 24 Jan 13
       
      It is important not to exaggerate your findings, so I think it is good that they are honest with areas of the research that are still not definitive.
  • enhanced levels of proinflammatory proteins in the blood of patients with acute coronary events and detectable levels of the EBV-related protein
  • having more of one of these proteins in the blood was linked to the presence of antibodies that signal a latent Epstein-Barr virus
  • ...4 more annotations...
  • looked for antibodies against a protein that can be produced even when only partial or incomplete reactivation of Epstein-Barr EBV occurs
  • EBV, a human herpes virus that causes infectious mononucleosis and several different types of tumors
  • Stress is a known predictor of reactivation of EBV, meaning virus reactivation could be a mechanism by which stress leads to chronic inflammation and eventually cardiovascular diseases.
  • viral proteins can induce inflammation, affecting the lining of blood vessels, so that inflammation is in the right place to function as a significant risk factor for heart disease
Casey Finnerty

The Virus That Learns - Phenomena: The Loom - 0 views

phenomena.nationalgeographic.com/...the-virus-that-learns

microbiology CRISPR

shared by Casey Finnerty on 07 Mar 13 - No Cached
  • Likewise, restriction enzymes are a dangerous defense, because they can chop up the distinctive stretches of DNA in a bacterium’s own genes. It avoids attacking itself by capping those sequences in its own DNA, so that the restriction enzymes can’t reach them.
  • Some species can muck up the production of new viruses, stealing their proteins before they can form shells. Others commit suicide upon infection, so as to avoid becoming an incubator for new viruses that would then kill their nearby relatives.
  • CRISPR genes can produce RNA molecules with a matching sequence. They grab onto the virus’s RNA and prevent them from being turned into proteins. The virus factory grinds to a halt.
  • ...6 more annotations...
  • The bacteria hold onto an invading virus’s DNA, so that they are now prepared for a fresh attack. And over time, bacteria can build up little libraries of these virus barcodes. 
  • Last year, scientists at Indiana University surveyed the bacteria in people’s mouths and discovered 8,000 different viral barcodes–many of them corresponding to viruses scientists have yet to discover.
  • But if you build up a healthy store of antibodies to various strains of flu, smallpox, and other diseases, all that knowledge dies with you.
  • Not so for bacteria. When a microbe reproduces, it passes down its CRISPR genes and all of their viral barcodes to its descendants–including the ones it acquired in its own lifetime.
  • Last fall, for example, University of Cambridge scientists discovered viruses that carry an antidote for the suicide toxin made by their hosts. When the bacteria want to die, the virus forces them to live on. And just last month, University of Toronto scientists even discovered anti-CRISPR genes in viruses, which the viruses use to shut down the production of virus-killing molecules.
  • the scientists demonstrated that the ICP1 virus uses its CRISPR immune system to attack its host’s virus-attacking genes.
Elijah Velasquez

Researchers devise technique to allow X-ray crystallography of un-crystallized molecule... - 0 views

phys.org/...-un-crystallized-molecule.html

shared by Elijah Velasquez on 03 Apr 13 - No Cached
  • Elijah Velasquez on 03 Apr 13
     
    If this was around during the discovery of antibody structure we might not have Fc and Fab regions!
Whitney Hopfauf

Lyme disease vaccine? Tick saliva found to protect mice from Lyme disease - 0 views

www.sciencedaily.com/...091119111410.htm

lyme vaccine microbiology

shared by Whitney Hopfauf on 11 Apr 13 - No Cached
  • antibodies against a protein in the saliva of a pathogen's transmitting agent
  • has been shown to confer immunity when administered protectively as a vaccine.
  • Lyme bacterium known as
  • ...6 more annotations...
  • Borrelia burgdorferi
  • . When it moves through the tick, it is coated with a tick salivary protein known as Salp15
  • injected Salp15 into healthy mice and found that it significantly protected them from getting Lyme disease
  • combined with outer surface proteins of B. burgdorferi, the protection was even greater.
  • Lyme vaccine on the market that utilized just the outer surface proteins of the bacteria. It was taken off the market in 2002
  • targeting the saliva -- the "vector molecule" that a microbe requires to infect a host -- may be applicable not just to Lyme disease but to other insect-borne pathogens
  • Whitney Hopfauf on 11 Apr 13
     
    This is slightly out of date but very interesting
anonymous

Clostridium perfringens vaccines - 1 views

www.sciencedirect.com/...S0264410X09010524

shared by anonymous on 30 Apr 13 - No Cached
  • anonymous on 30 Apr 13
     
    The vaccine routes would use non-toxic fragments of alpha toxin or a non-toxic forms of whole toxin as immunogens. The antibodies would protect the alpha-toxins from binding to the C-domain cell membrane allowing for leukocytes to clear the bacteria.
loryn_micro

ScienceDirect.com - The Veterinary Journal - Accuracy of a point-of-care ELISA test kit... - 0 views

www.sciencedirect.com/...S1090023312000639

shared by loryn_micro on 29 Apr 13 - No Cached
  • loryn_micro on 29 Apr 13
     
    Supplementary Journal Article for Presentation
Nellie Bogunovic

New Tool for Identifying Powerful HIV Antibodies - 0 views

www.sciencedaily.com/...130509142056.htm

shared by Nellie Bogunovic on 10 May 13 - No Cached
  • Nellie Bogunovic on 10 May 13
     
    This would give them a better idea on how to design the HIV vaccine
Charles Bach

Immune response to B19 parvovirus and an antibody defect in persistent viral infection. - 0 views

www.ncbi.nlm.nih.gov/...PMC329767

shared by Charles Bach on 03 May 13 - No Cached
  • Charles Bach on 03 May 13
     
    Study about the B19 Parvovirus in humans. This virus does not infect dogs or cats and is limited to humans. It is only transmitted between humans. Symptoms are also very different than the CPV virus in canines.
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