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Scientists call these two shapes the prefusion and postfusion forms of the spike. Antibodies against the prefusion shape work powerfully against the coronavirus, but postfusion antibodies don’t stop it.

they discovered a way to keep the protein locked in a tulip-like prefusion shape. All they had to do was change two of more than 1,000 building blocks in the protein into a compound called proline.

All three of the vaccines that have been authorized so far in the United States — from Johnson & Johnson, Moderna and Pfizer-BioNTech — use the 2P spike.

Other vaccine makers are using it as well. Novavax has had strong results with the 2P spike in clinical trials and is expected to apply to the Food and Drug Administration for emergency use authorization in the next few weeks. Sanofi is also testing a 2P spike vaccine and expects to finish clinical trials later this year.

Dr. McLellan’s ability to find lifesaving clues in the structure of proteins has earned him deep admiration in the vaccine world. “This guy is a genius,” said Harry Kleanthous, a senior program officer at the Bill & Melinda Gates Foundation. “He should be proud of this huge thing he’s done for humanity.”

The potency of the vaccine brought an extra benefit: The researchers needed fewer viruses for an effective dose. A single egg may yield five to 10 doses of NDV-HXP-S, compared to one or two doses of influenza vaccines.

In March, he joined forces with two fellow University of Texas biologists, Ilya Finkelstein and Jennifer Maynard. Their three labs created 100 new spikes, each with an altered building block. With funding from the Gates Foundation, they tested each one and then combined the promising changes in new spikes. Eventually, they created a single protein that met their aspirations.

The winner contained the two prolines in the 2P spike, plus four additional prolines found elsewhere in the protein. Dr. McLellan called the new spike HexaPro, in honor of its total of six prolines.

The structure of HexaPro was even more stable than 2P, the team found. It was also resilient, better able to withstand heat and damaging chemicals. Dr. McLellan hoped that its rugged design would make it potent in a vaccine.

the University of Texas set up a licensing arrangement for HexaPro that allows companies and labs in 80 low- and middle-income countries to use the protein in their vaccines without paying royalties.

The first wave of authorized Covid-19 vaccines require specialized, costly ingredients to make. Moderna’s RNA-based vaccine, for instance, needs genetic building blocks called nucleotides, as well as a custom-made fatty acid to build a bubble around them. Those ingredients must be assembled into vaccines in purpose-built factories.

The way influenza vaccines are made is a study in contrast. Many countries have huge factories for making cheap flu shots, with influenza viruses injected into chicken eggs. The eggs produce an abundance of new copies of the viruses. Factory workers then extract the viruses, weaken or kill them and then put them into vaccines.

once Dr. McLellan and his colleagues handed off the 2P spike to vaccine makers, he turned back to the protein for a closer look. If swapping just two prolines improved a vaccine, surely additional tweaks could improve it even more.

PATH then connected the Mount Sinai team with influenza vaccine makers. On March 15, Vietnam’s Institute of Vaccines and Medical Biologicals announced the start of a clinical trial of NDV-HXP-S. A week later, Thailand’s Government Pharmaceutical Organization followed suit. On March 26, Brazil’s Butantan Institute said it would ask for authorization to begin its own clinical trials of NDV-HXP-S.

n vaccine maker Avi-Mex as an intranasal spray. The company will start clinical trials to see if the vaccine is even more potent in that form.

"No specific training, policies, or procedures were in place for using helicopters to support requests for assistance from civilian authorities in civil disturbances," the report's authors wrote. "Prior to the night of June 1st, 2020, the DC [National Guard] did not have a prepared plan to maintain command and control of aviation assets used to support civil disturbances."Read More

Well after the curfew, protesters were still out on the streets, and video captured by CNN showed a military helicopter hovering over a group of them, kicking up strong wind and debris with its downwash. The tactic is a show of force and commonly used by the military in overseas combat zones to drive away targets from a specific area.

The Defense Department Inspector General largely agreed with an earlier report from an Army investigation that found the use of helicopters was not against federal laws or policies, though there was a "lack of understanding" about their mission.But the new report contradicted the Army investigation's finding that MEDEVAC helicopters were used against regulations and that the helicopters were used without approval from the chain of command.

Averting our gaze from the tragedies surrounding us, remaining divorced from reality, in our little bubbles, are political and moral choices. We have been willfully unaware of the ricketiness of our health-care system. The collective well-being of our nation depends on us showing solidarity with and compassion toward one another. No one is safe until everyone is.

Our actions compound, one small act at a time—not pressing for greater attention to the vulnerable, because we are safe; not demanding better hospitals for all Indians, because we can afford excellent health care; assuming we can seal ourselves off from our country’s failings toward our compatriots.

living in Bhopal, and seeing the impact the leak had, I learned early in life that monumental failures, like monumental successes, are collaborative efforts, involving both the actions people take and the signs they ignore.

What has happened since is perhaps more instructive. Indians have by and large forgotten the tragedy. The people of Bhopal have been left to deal with its fallout. Richer Indians have never had to visit the city, so they have ignored it. Yet their apathy signals a choice, a decision to look the other way as their fellow Indians suffer.

However inadvertently, we built the system that is failing us. Perhaps the COVID-19 crisis will teach us, as the gas tragedy should have taught us, that our decisions—to stay silent as others suffer—have consequences.

Argentina’s centre-right political opposition coalition Together For Change has fought tooth-and-nail against the restrictions that the progressive Peronist administration of president Alberto Fernández has sought to impose, claiming the health measures are a restriction of personal freedoms.

“There’s an attitude of: ‘People are going to die but I have the right to carry on with my life the way I used to,’” said Edul. “I understand people who need to go to work in the midst of this tremendous economic crisis, but the social discontent of a large part of the population is simply anger against restrictions on their daily lives.

“Intensive care doctors in Argentina have entered a point of terminal fatigue,” says Dubin.

Edul said: “Some of my colleagues have died of Covid, others are suffering from depression or have attempted suicide. Many who were working jobs in three different hospitals have quit one because of the stress.”

That depletion is in turn contributing to the high mortality rate. “It doesn’t matter how many extra beds they put in wards – what we have is a collapse of the system because there are not enough doctors,” says Edul.

Vaccination is progressing slowly, with only 18% of Argentinians having received at least one dose so far, mostly the Russian Sputnik V and Chinese Sinopharm jabs, though AstraZeneca has promised to deliver 4m doses before the end of May.

a two-tiered society. While major metropolises like Seoul continue to grow, putting intense pressure on infrastructure and housing, in regional towns it’s easy to find schools shut and abandoned, their playgrounds overgrown with weeds, because there are not enough children.

according to projections by an international team of scientists published last year in The Lancet, 183 countries and territories — out of 195 — will have fertility rates below replacement level by 2100.

Their model shows an especially sharp decline for China, with its population expected to fall from 1.41 billion now to about 730 million in 2100.

China would have as many 85-year-olds as 18-year-olds.

Demographers warn against seeing population decline as simply a cause for alarm. Many women are having fewer children because that’s what they want. Smaller populations could lead to higher wages, more equal societies, lower carbon emissions and a higher quality of life for the smaller numbers of children who are born.

ut, said Professor Gietel Basten, quoting Casanova: “There is no such thing as destiny. We ourselves shape our lives.”

The challenges ahead are still a cul-de-sac — no country with a serious slowdown in population growth has managed to increase its fertility rate much beyond the minor uptick that Germany accomplished. There is little sign of wage growth in shrinking countries, and there is no guarantee that a smaller population means less stress on the environment.

Many demographers argue that the current moment may look to future historians like a period of transition or gestation, when humans either did or did not figure out how to make the world more hospitable — enough for people to build the families that they want.

The No. 1 pick for people leaving San Francisco is Austin, Texas, with other winners including Seattle, New York and Chicago, according to moveBuddha, a site that compiles data on moving.

The biggest tech companies aren’t going anywhere, and tech stocks are still soaring. Apple’s flying-saucer-shaped campus is not going to zoom away. Google is still absorbing ever more office space in San Jose and San Francisco. New founders are still coming to town.

But the migration from the Bay Area appears real. Residential rents in San Francisco are down 27 percent from a year ago, and the office vacancy rate has spiked to 16.7 percent, a number not seen in a decade.

Pinterest, which has one of the most iconic offices in town, paid $90 million to break a lease for a site where it planned to expand. And companies like Twitter and Facebook have announced “work from home forever” plans.

Now the local tech industry is rapidly expanding. Apple is opening a $1 billion, 133-acre campus. Alphabet, Amazon and Facebook have all either expanded their footprints in Austin or have plans to. Elon Musk, the Tesla founder and one of the two richest men in the world, said he had moved to Texas. Start-up investor money is arriving, too: The investors at 8VC and Breyer Capital opened Austin offices last year.

The San Francisco exodus means the talent and money of newly remote tech workers are up for grabs. And it’s not just the mayor of Miami trying to lure them in.

There are 33,000 members in the Facebook group Leaving California and 51,000 in its sister group, Life After California. People post pictures of moving trucks and links to Zillow listings in new cities.

If San Francisco of the 2010s proved anything, it’s the power of proximity. Entrepreneurs could find a dozen start-up pitch competitions every week within walking distance. If they left a big tech company, there were start-ups eager to hire, and if a start-up failed, there was always another.

No one leaving the city is arguing that a culture of innovation is going to spring up over Zoom. So some are trying to recreate it. They are getting into property development, building luxury tiny-home compounds and taking over big, funky houses in old resort towns.

The objects and structural remnants on display in the museum paint a vivid picture of wealth, power and opulence. Among the stunning examples of ancient Roman artistry are elaborate mosaics and frescoes, a marble staircase, capitals of colored marble and limestone, and an imperial guard’s bronze brooch inset with gold and mother-of-pearl. “All the most refined objects and art produced in the Imperial Age turned up,” Dr. Serlorenzi said.

“The frescoes are incredibly ornate and of a very high decorative standard,”

“Given the descriptions of Caligula’s licentious lifestyle and appetite for luxury, we might have expected the designs to be quite gauche.”

Evidence suggests that after Caligula’s violent death — he was hacked to bits by his bodyguards — the house and garden survived at least until the Severan dynasty, which ruled from A.D. 193 to 235. By the fourth century, the gardens had apparently fallen into desuetude, and statuary in the abandoned pavilions was broken into pieces to build the foundations of a series of spas. The statues were not discovered until 1874, three years after Rome was made the capital of the newly unified Kingdom of Italy.

The latest excavation of the horti unfolded under the detritus of the residences, which had been evacuated in the 1970s in the wake of a building collapse.

I doubt these new discoveries will do much to rehabilitate his character. But they should open up new vistas onto his world, and reveal it to be every bit as paradisiacal as he desired it to be.”

The federal death chamber, at the U.S. Penitentiary in Terre Haute, Ind., likely will be mothballed after Mr. Higgs’s execution. No further executions currently are scheduled, and Mr. Biden, who has called for the legal abolition of capital punishment, is unlikely to approve any others. With Mr. Higgs’s execution, 50 inmates will remain on the federal death row, according to the Death Penalty Information Center, which is critical of capital punishment.

Mr. Higgs delivered a final statement before he was put to death. “The tone of his voice when he said his final words was calm but in substance Higgs was defiant,” according to an Associated Press pool report. “‘I’d like to say I am an innocent man,’ he said, mentioning the three women by name. ‘I did not order the murders.’”

Following the execution, the prison released a statement addressed to Mr. Higgs from Ms. Jackson’s younger sister, whom it did not identify by name. “When the day is over, your death will not bring my sister and the other victims back. This is not closure, this is the consequence of your actions,” it said.

The government, arguing that litigating the issue would needlessly delay Mr. Higgs’s execution, asked the Supreme Court to overrule the lower courts. Friday’s order did just that, directing “the prompt designation of Indiana” as the state whose death penalty procedures should be followed. The majority provided no legal explanation for the decision, but in prior cases some conservative justices have complained that condemned inmates game the system by filing last-minute appeals to prolong their lives.

Trump and Vice President Mike Pence were notified about Baghdadi's possible location "earlier in the week" and told Thursday that there was a high probability he was in the compound.

g: "Something big has just happened."

"Russia treated us great. They opened up. We had a fly over certain Russia areas, Russia-held areas. Russia was great. Iraq was excellent. We really had great cooperation," the President told reporters Sunday.

"world's number one terrorist leader" is dead.

ISIS leader Abu Bakr al-Baghdadi "blew himself up"

He formed ISIS in 2014, he led to establishing the physical caliphate throughout the region, so this is a major blow to them,

“He is irreplaceable and indispensable” to Iran’s military establishment.

The United States said that Kataib Hezbollah fired 31 rockets into a base in Kirkuk Province, last week, killing an American contractor and wounding several American and Iraqi servicemen.

The Americans responded by bombing three sites of the Khataib Hezbollah militia near Qaim in western Iraq and two sites in Syria. Khataib Hezbollah denied involvement in the attack in Kirkuk.

Pro-Iranian militia members then marched on the American Embassy on Tuesday, effectively imprisoning its diplomats inside for more than 24 hours while thousands of militia members thronged outside. They burned the embassy’s reception area, planted militia flags on its roof and scrawled graffiti on its walls.

President Trump said on Tuesday that Iran would “be held fully responsible” for the attack on the embassy, in which protesters set fire to a reception building on the embassy compound, which covers more than 100 acres. He also blamed Tehran for directing the unrest.

General Suleimani led the Islamic Revolutionary Guards Corps’ Quds Force, a special forces unit responsible for Iranian operations outside Iran’s borders. He once described himself to a senior Iraqi intelligence official as the “sole authority for Iranian actions in Iraq,” the official later told American officials in Baghdad.In his speech denouncing Mr. Trump, he was even less discreet — and openly mocking.“We are near you, where you can’t even imagine,” he said. “We are ready. We are the man of this arena.”

Mr. Trump, who aides said had on his mind the specter of the 2012 attacks on the American compound in Benghazi, Libya, became increasingly angry as he watched television images of pro-Iranian demonstrators storming the embassy. Aides said he worried that no response would look weak after repeated threats by the United States.

When Mr. Trump chose the option of killing General Suleimani, top military officials, flabbergasted, were immediately alarmed about the prospect of Iranian retaliatory strikes on American troops in the region. It is unclear if General Milley or Mr. Esper pushed back on the president’s decision.

The option that was eventually approved depended on who would greet General Suleimani at his expected arrival on Friday at Baghdad International Airport. If he was met by Iraqi government officials allied with Americans, one American official said, the strike would be called off. But the official said it was a “clean party,” meaning members of Kataib Hezbollah, including its leader, Abu Mahdi al-Muhandis. Mr. Trump authorized the killing at about 5 p.m. on Thursday, officials said.

His deeds are beside the point; so is the display of American resolve. The only reason to kill Soleimani is to enter a new war that the United States can win.

What would that war look like? How will Iran fight it? How will the U.S. respond?

What credible allies will we have, after Trump’s trashing of the nuclear deal thoroughly alienated Europe?

Who will believe any intelligence about Iran’s actions and intentions from an administration that can’t function without telling lies? How will American officials deliberate when Trump has gotten rid of his experts and turned his government into a tool of personal power

What is our war aim, and how can it be aligned with Trump’s obvious desire to be rid of any entanglement in the region?

What will the American people accept by way of sacrifice, when nothing has prepared them for this?

There’s no sign that anyone in power, least of all the president, has even asked these questions, let alone knows how to answer them.

one prediction I’m willing to make is that events will shortly obliterate these official statements.

The strike had nothing to do with deterrence. Pompeo’s own department is warning Americans in Iraq: “U.S. citizens should depart via airline while possible, and failing that, to other countries via land. Due to Iranian-backed militia attacks at the U.S. Embassy compound, all public consular operations are suspended until further notice. U.S. citizens should not approach the Embassy.”

Killing Soleimani will only lead to more violence, perhaps much more.

Neither Iran nor the United States knows how to read the other’s intentions—each is prone to underestimation—leaving the two countries to lash out in the dark.

A crisis acts like a barium test—it reveals the nature and health of a system. The Soleimani crisis shows a rash and vain president for whom everything is personal; a government that follows no coherent strategy because its leadership can’t provide one; and a Congress and public too irreconcilably divided to rally around a national goal

In this condition, we don’t know how to think about a war with Iran, let alone win one, and it’s not at all clear why we should try. For this reason, killing Soleimani was a blunder—briefly satisfying, possibly catastrophic.

Instead, the House rushed its investigation and compounded the problem by stalling the transfer of the articles of impeachment to the Senate. Meanwhile, the public lost interest. The stall time could have been used to test the subpoenas in court and possibly develop a stronger obstruction case.

We’ve taken the people with the least amount of resources and capacity and asked them to do the hardest part of the vaccination — which is actually getting the vaccines administered into people’s arms,” said Dr. Ashish Jha, the dean of Brown University’s School of Public Health.Coronavirus Briefing: An informed guide to the global outbreak, with the latest developments and expert advice.Sign UpFederal and state officials have denied they are to blame for the slow rollout. Officials behind Operation Warp Speed, the federal effort to fast-track vaccines, have said that their job was to ensure that vaccines are made available and get shipped out to the states. President Trump said in a tweet on Tuesday that it was “up to the States to distribute the vaccines once brought to the designated areas by the Federal Government.”“Ultimately, the buck seems to stop with no one,” Dr. Jha said.These problems are especially worrisome now that a new, more contagious variant, first spotted in Britain and overwhelming hospitals there, has arrived in the United States. Officials in two states, Colorado and California, say they have discovered cases of the new variant, and none of the patients had recently traveled, suggesting the variant is already spreading in American communities.The $900 billion relief package that Mr. Trump signed into law on Sunday will bring some relief to struggling state and local health departments. The bill sets aside more than $8 billion for vaccine distribution, on top of the $340 million that the C.D.C. sent out to the states in installments in September and earlier in December.

Over all, Maryland has given nearly 17 percent of its vaccine doses. In a Wednesday appearance on CBS, Gov. Larry Hogan attributed the slow process to challenges across the board — from the federal government not sending as many doses as initially predicted, to the lack of logistical and financial support for local health departments.

In a news conference on Wednesday, Operation Warp Speed officials said they expected the pace of the rollout to accelerate significantly once pharmacies begin offering vaccines in their stores. The federal government has reached agreements with a number of pharmacy chains — including Costco, Walmart and CVS — to administer vaccines once they become more widely available. So far, 40,000 pharmacy locations have enrolled in that program.

But public health officials warned that reaching these initial groups, who are largely being vaccinated where they live or work, is a relatively easy task. “This is the part where we’re supposed to know where people are,” said Dr. Saad B. Omer, the director of the Yale Institute for Global Health.

Uighurs are not ethnically or culturally Chinese, but a Turkic people whose language is close to the Uzbek of nearby Uzbekistan and distantly related to the Turkish of Turkey.

. In 1955 the PRC created the Xinjiang Uighur Autonomous Region as a concession to the non-Han population and in parallel with similar arrangements for Tibet and Inner Mongolia

As China emerged from the horrors of the Cultural Revolution, the power of the Chinese Communist Party recovered; there was no equivalent liberation for the Uighurs.

In August 2016 Xi appointed Chen Quanguo, who had previously ruled Tibet, as Xinjiang Party Secretary: he rapidly introduced draconian measures of repression – ‘counter-terrorism’ in the official terminology – including the now notorious concentration camps and advanced surveillance technology. The clampdown on religious activities has intensified and satellite images indicate that many mosques and Sufi shrines have been destroyed, including the Imam Asim shrine outside Khotan, the site of an annual festival attended by thousands of pious Uighur Muslims. This intensification of repression shows no sign of ending.

The repression under the ‘Strike Hard’ campaign became permanent. Anyone suspected of sympathies for ‘separatism’ – advocating an independent Uighur state – or involvement in ‘illegal religious activities’, primarily with the Sufi brotherhoods – could be detained without trial. Attempts by family members to extract relatives from police stations or other detention facilities have led to frequent clashes with the authorities, many of which have turned violent. Sporadic attacks against the police or other symbols of Chinese rule, either by local people or armed militant groups, were followed by government reprisals. Most conflict occurred in the old Sufi strongholds in the south of Xinjiang but, in July 2009, clashes between Uighurs and Han Chinese in the regional capital, Urumqi, cost many lives. They also resulted in the detention of thousands of Uighurs, some of whom were executed, and the eventual replacement in April 2010 of the Xinjiang Communist Party Secretary, Wang Lequan, who had held the post since 1994. The level of repression and the secrecy of judicial processes aroused widespread international concerns about human rights abuses.

Demonstrations in 1995 in Yining, the base of the 1940s’ independent republic, provoked Beijing to issue Document No. 7 the following year. It identified the conflict in Xinjiang as the most serious threat to the Chinese state and a ‘Strike Hard’ campaign was launched against resisters. In 1997 another major Yining demonstration in the north-east of the state was violently suppressed.

It was being used to detain hundreds of thousands of – some estimates suggested over a million – members of the Muslim Uighur community suspected of involvement in, or sympathy for, demonstrations and attacks on government institutions.

productive work.

e is evidence

As the historian Jelani Cobb noted in The New Yorker two months before the election, America’s record of willfully ignoring the violent suppression of Black voting rights is much more extensive than its record of protecting Black voters. While the public tends to view instances of election violence “as a static record of the past,” he wrote, “historians tend to look at them the way that meteorologists look at hurricanes: as a predictable outcome when a number of recognizable variables align in familiar ways.”

They would thus serve the twin aims of ensuring that the “energy in the executive” that Alexander Hamilton defined as “a leading character in the definition of good government” is nonetheless embedded, as the historian Arthur Schlesinger Jr. rightly insisted, in a “system of accountability that checks the abuse of executive power.”

Covid-19 is crushing the healthcare system, with the California Department of Public Health reporting around 39,000 daily new cases and hundreds of deaths a day as of December 23

First and foremost, it is important to adhere to the key public health measures: masks, social distancing, avoidance of crowds. This approach remains effective, even if it has been adopted unevenly across the country. After 11 months, however, adhering to these measures can be extremely tedious and at times seemingly intolerable -- even for the most ardent public health fans, including myself.

Yes, it has given hope to the world, but it also may seduce people into thinking wrongly that it will be OK to ease up on preventative measures before the vaccine is widely available.

Forgoing masks and social distancing will only compound this national tragedy. We are currently seeing roughly 200,000 daily new cases and more than 2,500 deaths in the U.S. per day

Of the Trump administration's many Covid-19 failures, its inability to develop a modern, convenient and reliable national testing program is the most unforgivable.

Germany and South Korea have made this the cornerstone of their effective control programs, while Hong Kong has placed test kit vending machines in subway stations. And professional sport leagues have made testing several times a week a core approach to their containment strategy.

Yet we are only performing averages of less than 2 million tests per day in the U.S. While this is about double the rate in September, it still falls far short of what is necessary. In April, experts called for at least 5 million tests a day by early June to ensure a safe social opening, and 20 million tests a day by mid-summer to remobilize the economy. Others have hoped for even more aggressive goals to "test nearly everyone, nearly every day."

President-elect Joe Biden appears to understand the value of this strategy, which could bridge the many vulnerable months between now and the development of vaccine-induced herd immunity.

The backlash against Mr. Carlson and Fox for daring to exert even a moment of independence underscores how little willingness exists among Republicans to challenge the president and his false narrative about the election he insists was stolen.

The same fear that grips elected Republicans — getting on the wrong side of voters who adore Mr. Trump but have little affection for the Republican Party — has kept conservative media largely in line. And that has created a right-wing media bubble that has grown increasingly disconnected from the most basic facts about American government in recent weeks, including who will be inaugurated as president on Jan. 20, 2021.

Roosh Valizadeh, a writer and podcast host who supports the president, summed up the anger aimed at Fox by many on the right, saying, “As long as Tucker Carlson works for Fox News, he can’t be fully trusted.

All week on networks like Newsmax and OANN and talk radio programs, the president’s supporters have been given a steady diet of interviews with Trump allies, campaign officials and news stories that promote allegations of fraud with little or no context

Rich Lowry, the editor of National Review and sometimes critic of the president who called his refusal to concede “absurd and sophomoric,” said that whether it was a Republican politician or a talk-show host, breaking the will that many Trump supporters have to believe he is the rightful winner was extremely difficult.

“They want it to be true,” Mr. Lowry said. “On top of that, there’s an enormous credibility gap and radical distrust of other sources of information. And that’s compounded by the fact that the president has no standards and is surrounded by these clownish people who will say anything. It’s a toxic stew.”

Mr. Lowry added that he thought Mr. Carlson’s words were “admirable” and had told the Fox host so himself. “It’s one thing for people who’ve been opposed to Trump all along, or mixed, to say something like that,” Mr. Lowry said. “It’s another thing for a leader of the populist wing of the conservative movement to call it out.”

“Drudge and Fox can try to pull back from the abyss,” said Yochai Benkler, a professor at Harvard Law School who studies conservative media. “But the audience is going to get what it wants and reward those who give it to them.”

Mr. Carlson is no ordinary Trump critic. He has been one of the president’s most aggressive defenders in prime time, especially when it came to standing up for Mr. Trump as he attacked African-American politicians, athletes and the racial justice activists in the Black Lives Matter movement. He has also generally bought into the disproved notion that voter fraud is a widespread problem — a popular position with Mr. Trump and on Mr. Carlson’s network.

He has not been shy in criticizing aspects of the president’s policies he disagrees with, whether the bombing raid in Iraq that killed Iran’s top general, Qassim Suleimani, or Mr. Trump’s failure to take the coronavirus pandemic seriously when it started spreading last winter. But he has never gone out on a limb like this, with the president and his followers so besieged.

He also tried to reassure his audience that he was on their side after all, explaining how he always kept an open mind about alleged cover-ups like the one Ms. Powell has promoted. “We don’t dismiss anything,” he said. “We literally do U.F.O. segments.”

Defining executive underreach isn’t easy, since the executive is endowed with the discretion to opt for inaction. So the paper suggests this:Underreach occurs when domestic and international legal sources are widely seen to authorize, if not also encourage or oblige, an executive to tackle a particular sort of problem with particular sorts of tools and yet the executive declines to do so.

the paper notes that it occurs when the rationale for inaction is offered in naked and destructive bad faith, as Trump has been doing for months.

Authoritarian and autocratic impulses perhaps belong in a separate category from illiberal and anti-democratic ones. But there’s plenty of overlap: Wielding disinformation to supplant solutions in the public interest and prodding friendly governors into putting untold constituents at risk — all to serve the leader’s cultish political needs — surely partake from both.

In the leadership context, when incompetence and the distraction of narcissism do appear, they don’t necessarily hamper the realization of illiberal and anti-democratic tendencies. They are rooted in the same tangle of impulses, and mutually reinforce each other in a uniquely toxic way that compounds the wreckage.