Duration of vitamin D synthesis from weather model data for use in prospective epidemiological studies.
Edvardsen K, Engelsen O, Brustad M.
Int J Biometeorol. 2009 Sep;53(5):451-9. Epub 2009 May 15.
PMID: 19444487
Serum 25(OH)-vitamin D concentration and risk of esophageal squamous dysplasia.
Abnet CC, Chen W, Dawsey SM, Wei WQ, Roth MJ, Liu B, Lu N, Taylor PR, Qiao YL.
Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1889-93.
PMID: 17855710
doi: 10.1158/1055-9965.EPI-07-0461
Background: Squamous dysplasia is the precursor lesion for esophageal squamous cell carcinoma, and nutritional factors play an important role in the etiology of this cancer. Previous studies using a variety of measures for vitamin D exposure have reached different conclusions about the association between vitamin D and the risk of developing esophageal cancer.
Conclusions: Higher serum 25(OH)D concentrations were associated with significantly increased risk of squamous dysplasia. No obvious source of measured or unmeasured confounding explains this finding.
In conclusion, we found that a higher serum 25(OH)D concentration was associated with an increased risk of esophageal squamous dysplasia, the precursor lesion for ESCC. This finding concurs with our previous prospective study which found that higher vitamin D status was associated with increased risk of incident ESCC in this same population. These unexpected findings suggest that further studies of the association of vitamin D and digestive tract cancers are needed before the effect of vitamin D in different populations can be elucidated.
How to optimize vitamin D supplementation to prevent cancer, based on cellular adaptation and hydroxylase enzymology.
Vieth R.
Anticancer Res. 2009 Sep;29(9):3675-84. Review.
PMID: 19667164
"I recently received an email from the Vitamin D Council regarding recent evidence that having adequate serum Vitamin D levels could be very important to avoiding illness from the H1N1 (swine) flu that is making the rounds. That will seem intuitive to those of you who read my earlier post about D, but it's good to see some real evidence. Some of you may have seen this information already on other blogs, including Richard's, but I have some new information and some comments to add."
Effects of vitamin D supplementation on strength, physical performance, and falls in older persons: a systematic review.
Latham NK, Anderson CS, Reid IR.
J Am Geriatr Soc. 2003 Sep;51(9):1219-26. Review.
PMID: 12919233
DOI: 10.1046/j.1532-5415.2003.51405.
Conclusion: Although there is insufficient evidence that vitamin D supplementation alone improves physical performance in older people, some data suggest a benefit from vitamin D combined with calcium supplementation, but this requires confirmation in large, well-designed trials.
Safety of vitamin D3 in adults with multiple sclerosis.
Kimball SM, Ursell MR, O'Connor P, Vieth R.
Am J Clin Nutr. 2007 Sep;86(3):645-51.
PMID: 17823429
Conclusions: Patients' serum 25(OH)D concentrations reached twice the top of the physiologic range without eliciting hypercalcemia or hypercalciuria. The data support the feasibility of pharmacologic doses of vitamin D3 for clinical research, and they provide objective evidence that vitamin D intake beyond the current upper limit is safe by a large margin.
The effect of vitamin D2 and vitamin D3 on intestinal calcium absorption in Nigerian children with rickets.
Thacher TD, Obadofin MO, O'Brien KO, Abrams SA.
J Clin Endocrinol Metab. 2009 Sep;94(9):3314-21. Epub 2009 Jun 30.
PMID: 19567516
Conclusions: Despite similar increases in 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D with vitamin D2 or vitamin D3, fractional calcium absorption did not increase, indicating that rickets in Nigerian children is not primarily due to vitamin D-deficient calcium malabsorption
Association of vitamin D deficiency with cognitive impairment in older women. Cross-sectional study.
Annweiler C, Schott AM, Allali G, Bridenbaugh SA, Kressig RW, Allain P, Herrmann FR, Beauchet O.
Neurology. 2009 Sep 30. [Epub ahead of print]
PMID: 19794127
doi:10.1212/WNL.0b013e3181beecd3
Conclusions: 25-Hydroxyvitamin D deficiency was associated with cognitive impairment in this cohort of community-dwelling older women.