Prospective Study of Serum 25-Hydroxyvitamin D Level, Cardiovascular Disease Mortality, and All-Cause Mortality in Older U.S. Adults.
Ginde AA, Scragg R, Schwartz RS, Camargo CA Jr.
J Am Geriatr Soc. 2009 Jun 22. [Epub ahead of print]
PMID: 19549021
DOI: 10.1111/j.1532-5415.2009.02359.x
CONCLUSION: In noninstitutionalized older adults, a group at high risk for all-cause mortality, serum 25(OH)D levels had an independent, inverse association with CVD and all-cause mortality. Randomized controlled trials of vitamin D supplementation in older adults are warranted to determine whether this association is causal and reversible.
Urgent action needed to improve vitamin D status among older people in England!
Hirani V, Tull K, Ali A, Mindell J.
Age Ageing. 2009 Nov 23. [Epub ahead of print]
PMID: 19934073
CONCLUSIONS: poor vitamin D status of older people continues to be a public health problem in England. Hypovitaminosis D is associated with many risk factors and poor health outcomes. There is now an urgent need for a uniform policy on assessment and dietary supplementation of vitamin D in older people to prevent poor vitamin D status and its negative consequences
A new study by researchers at the University of Colorado Denver and Massachusetts General Hospital (MGH) shows vitamin D plays a vital role in reducing the risk of death associated with older age. The research, just published in the Journal of the American Geriatrics Society, evaluated the association between vitamin D levels in the blood and the death rates of those 65 and older. The study found that older adults with insufficient levels of vitamin D die from heart disease at greater rates that those with adequate levels of the vitamin.
Vitamin D status predicts physical performance and its decline in older persons.
Wicherts IS, van Schoor NM, Boeke AJ, Visser M, Deeg DJ, Smit J, Knol DL, Lips P.
J Clin Endocrinol Metab. 2007 Jun;92(6):2058-65. Epub 2007 Mar 6.
PMID: 17341569
doi:10.1210/jc.2006-1525
ONCLUSIONS: Serum 25-OHD concentrations below 20 ng/ml are associated with poorer physical performance and a greater decline in physical performance in older men and women. Because almost 50% of the population had serum 25-OHD below 20 ng/ml, public health strategies should be aimed at this group.
Summary of evidence-based review on vitamin D efficacy and safety in relation to bone health.
Cranney A, Weiler HA, O'Donnell S, Puil L.
Am J Clin Nutr. 2008 Aug;88(2):513S-519S. Review.
PMID: 18689393
We found inconsistent evidence of an association between serum 25-hydroxyvitamin D [25(OH)D] concentration and bone mineral content in infants and fair evidence of an association with bone mineral content or density in older children and older adults. The evidence of an association between serum 25(OH)D concentration and some clinical outcomes (fractures, performance measures) in postmenopausal women and older men was inconsistent, and the evidence of an association with falls was fair. We found good evidence of a positive effect of consuming vitamin D-fortified foods on 25(OH)D concentrations. The evidence for a benefit of vitamin D on falls and fractures varied. We found fair evidence that adults tolerated vitamin D at doses above current dietary reference intake levels, but we had no data on the association between long-term harms and higher doses of vitamin D.
Depression is associated with decreased 25-hydroxyvitamin D and increased parathyroid hormone levels in older adults.
Hoogendijk WJ, Lips P, Dik MG, Deeg DJ, Beekman AT, Penninx BW.
Arch Gen Psychiatry. 2008 May;65(5):508-12.
PMID: 18458202
Conclusion The results of this large population-based study show an association of depression status and severity with decreased serum 25(OH)D levels and increased serum PTH levels in older individuals.
Vitamin D deficiency is associated with worse cognitive performance and lower bone density in older African Americans.
Wilkins CH, Birge SJ, Sheline YI, Morris JC.
J Natl Med Assoc. 2009 Apr;101(4):349-54.
PMID: 19397226
CONCLUSIONS: Vitamin D deficiency in older African Americans was associated with worse cognitive performance and lower BMD of the hip
Effects of vitamin D supplementation on strength, physical performance, and falls in older persons: a systematic review.
Latham NK, Anderson CS, Reid IR.
J Am Geriatr Soc. 2003 Sep;51(9):1219-26. Review.
PMID: 12919233
DOI: 10.1046/j.1532-5415.2003.51405.
Conclusion: Although there is insufficient evidence that vitamin D supplementation alone improves physical performance in older people, some data suggest a benefit from vitamin D combined with calcium supplementation, but this requires confirmation in large, well-designed trials.
Low serum 25-hydroxyvitamin D concentrations are associated with greater all-cause mortality in older community-dwelling women.
Semba RD, Houston DK, Ferrucci L, Cappola AR, Sun K, Guralnik JM, Fried LP.
Nutr Res. 2009 Aug;29(8):525-30.
PMID: 19761886
doi:10.1016/j.nutres.2009.07.007
Older community-dwelling women with low 25(OH)D levels are at an increased risk of death.
Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men.
Lee DM, Tajar A, Ulubaev A, Pendleton N, O'Neill TW, O'Connor DB, Bartfai G, Boonen S, Bouillon R, Casanueva FF, Finn JD, Forti G, Giwercman A, Han TS, Huhtaniemi IT, Kula K, Lean ME, Punab M, Silman AJ, Vanderschueren D, Wu FC; EMAS study group.
J Neurol Neurosurg Psychiatry. 2009 Jul;80(7):722-9. Epub 2009 May 21.
PMID: 19460797
doi:10.1136/jnnp.2008.165720
Conclusion: In this study, lower 25(OH)D levels were associated with poorer performance on the DSST. Further research is warranted to determine whether vitamin D sufficiency might have a role in preserving cognitive function in older adults.
Association of vitamin D deficiency with cognitive impairment in older women. Cross-sectional study.
Annweiler C, Schott AM, Allali G, Bridenbaugh SA, Kressig RW, Allain P, Herrmann FR, Beauchet O.
Neurology. 2009 Sep 30. [Epub ahead of print]
PMID: 19794127
doi:10.1212/WNL.0b013e3181beecd3
Conclusions: 25-Hydroxyvitamin D deficiency was associated with cognitive impairment in this cohort of community-dwelling older women.
Age-related changes in the 25-hydroxyvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D.
Vieth R, Ladak Y, Walfish PG.
J Clin Endocrinol Metab. 2003 Jan;88(1):185-91.
PMID: 12519850
This study shows that all age groups exhibit a high prevalence of 25(OH)D insufficiency and secondary hyperparathyroidism. Older adults are just as efficient in maintaining 25(OH)D, but they need more vitamin D to produce the higher 25(OH)D concentrations required to overcome the hyperparathyroidism associated with their diminishing renal function
25(OH)D Serum levels decline with age earlier in women than in men and less efficiently prevent compensatory hyperparathyroidism in older adults.
Maggio D, Cherubini A, Lauretani F, Russo RC, Bartali B, Pierandrei M, Ruggiero C, Macchiarulo MC, Giorgino R, Minisola S, Ferrucci L.
J Gerontol A Biol Sci Med Sci. 2005 Nov;60(11):1414-9.
PMID: 16339327
Conclusions. These findings suggest that the age-associated fall of serum 25(OH)D starts earlier in women than in men and that higher levels of 25(OH)D are required in older compared to younger persons to avoid the age-associated compensatory hyperparathyroidism.
Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials.
Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB, Orav JE, Stuck AE, Theiler R, Wong JB, Egli A, Kiel DP, Henschkowski J.
BMJ. 2009 Oct 1;339:b3692. doi: 10.1136/bmj.b3692.
PMID: 19797342
doi: 10.1136/bmj.b3692
Conclusions Supplemental vitamin D in a dose of 700-1000 IU a day reduced the risk of falling among older individuals by 19% and to a similar degree as active forms of vitamin D. Doses of supplemental vitamin D of less than 700 IU or serum 25-hydroxyvitamin D concentrations of less than 60 nmol/l may not reduce the risk of falling among older individuals.
Vitamin D supplementation improves neuromuscular function in older people who fall.
Dhesi JK, Jackson SH, Bearne LM, Moniz C, Hurley MV, Swift CG, Allain TJ.
Age Ageing. 2004 Nov;33(6):589-95.
PMID: 15501836
doi:10.1093/ageing/afh20 9
CONCLUSIONS: vitamin D supplementation, in fallers with vitamin D insufficiency, has a significant beneficial effect on functional performance, reaction time and balance, but not muscle strength. This suggests that vitamin D supplementation improves neuromuscular or neuroprotective function, which may in part explain the mechanism whereby vitamin D reduces falls and fractures.
Can vitamin D supplementation prevent winter-time blues? A randomised trial among older women.
Dumville JC, Miles JN, Porthouse J, Cockayne S, Saxon L, King C.
J Nutr Health Aging. 2006 Mar-Apr;10(2):151-3.
PMID: 16554952
CONCLUSIONS: Supplementing elderly women with 800 IU of vitamin D daily did not lead to an improvement in mental health scores.
Investigating the links between muscle strength, sun exposure, dietary vitamin D intake and the vitamin D status of ambulatory older adults in South East Queensland
Borradale, David (2008)
QUT Thesis]
Vitamin D supplementation to prevent infections: a sub-study of a randomised placebo-controlled trial in older people (RECORD trial, ISRCTN 51647438).\nAvenell A, Cook JA, Maclennan GS, Macpherson GC.\nAge Ageing. 2007 Sep;36(5):574-7. Epub 2007 Aug 15. No abstract available.\nPMID: 17702768 \ndoi:10.1093/ageing/afm091
Wicherts IS, van Schoor NM, Boeke AJ, Visser M, Deeg DJ, Smit J, Knol DL, Lips P.
Vitamin D status predicts physical performance and its decline in older persons.
J Clin Endocrinol Metab. 2007 Jun;92(6):2058-65. Epub 2007 Mar 6.
PMID: 17341569 [PubMed
Vitamin D Deficiency in Older Men.\nOrwoll E, Nielson CM, Marshall LM, Lambert L, Holton KF, Hoffman AR, Barrett-Connor E, Shikany JM, Dam T, Cauley JA; for the Osteoporotic Fractures in Men (MrOS) Study Group.\nJ Clin Endocrinol Metab. 2009 Jan 27. [Epub ahead of print]\nPMID: 19174492