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Although mind-bending drugs such as psilocybin are still used most often by people looking to get high, researchers around the country have begun to explore whether these and other illegal drugs can help treat intractable depression, anxiety, and other mental-health problems.

n the past month alone, studies have been published on the benefits of MDMA (better known as Ecstasy) in people with post-traumatic stress disorder and on the fast-acting antidepressive effects of the club drug ketamine (aka "Special K").

But research into the potential benefits of psychedelic drugs ground to a halt in the early 1970s, after the federal government criminalized LSD and psilocybin -- and after the drugs were eagerly adopted by college students and the hippie counterculture. "These studies had to be shut down because of the cultural reaction,"

Public bicycle sharing schemes such as Barcelona's "Bicing" program or London's "Boris Bikes" save lives and reduce greenhouse gas emissions, according to a study on Friday.

Researchers at the Center for Research in Environmental Epidemiology in Barcelona found in a study, however, that around 9,000 tons of carbon dioxide pollution are averted and some 12 lives saved each year by Barcelona's scheme, which was introduced in March 2007.

From this they estimated the number of deaths associated with traveling by bike compared with driving for three main factors -- physical activity, road traffic incidents and exposure to air pollution. They also estimated the reduction in carbon dioxide emissions.Looking at the Barcelona "Bicing" scheme, they calculated an annual increase of 0.13 deaths from air pollution and 0.03 deaths from traffic accidents among cyclists compared with car users.But as a result of high levels of physical activity, 12.46 deaths were avoided, making a total of 12.28 deaths avoided among cyclists every year, the researchers said. They also estimated a reduction in carbon emissions of over 9 million kg or 9,000 tons per year, the equivalent to flying 1,800 people to Sydney and back from london.The World Health Organization (WHO) recommends adults should do at least 150 minutes of moderate exercise a week and says this could be done by walking for 30 minutes five times per week or by cycling to work every day.

London’s original pledge evolved into a plan to get one million more people around England playing sports three or more times a week for at least 30 minutes at a time, known as the 3x30 plan. Even that target is proving elusive. Figures issued in December by Sport England, the governing body for community sports, indicated that participation at the 3x30 level had increased by 123,000 since 2007-8, when the one million baseline was established. But that number increased by only 8,000 in the last year. At the current rate, the goal of one million new participants would not be reached in 2012-13 as hoped but more than a decade later in 2023-24.

the number of adults doing zero moderate sports activity rose by nearly 300,000 from 2005, when London was awarded the Olympics, to the fall of 2010.

London is hardly the first host city to struggle with its Olympic legacy. In truth, international events like the Olympics and soccer’s World Cup leave a greater discernible impact on infrastructure than on sports. Roads, airports and rail systems are improved while a number of stadiums become white elephants and lingering sporting benefits remain indistinct. Six years after Albertville, France, hosted the 1992 Winter Olympics, the figure-skating arena and speed-skating oval there were fenced off and abandoned. The magnificent Olympic stadium showcased during the 2008 Beijing Games, known as the Bird’s Nest, was seldom being used a year and a half later.

According to a recent study, regular exercise improves the ability of inactive, overweight children to do better in math. Researchers at Georgia Health Sciences University studied 171 sedentary and overweight 7- to 11-year-olds in an effort to identify what happens to children's brains with regular, vigorous exercise.

After allowing the kids to engage in fun, playful exercises, such as running games, hula hooping and jump roping, which raised their heart rates to 79 percent of their maximum, scientists used the Cognitive Assessment System and Woodcock-Johnson Tests of Achievement III, tests that measure abilities such as planning and academic skills, to identify brain activity before and after the bouts of physical activity. Students showed an increase in complex thinking and decision making -- the areas of the brain that are used in math. In fact, the more the children exercised, the more their brains responded. Intelligence scores increased an average 3.8 points in those exercising 40 minutes per day for three months. Those who exercised just 20 minutes a day also benefited, just in a smaller dose. Researchers noted that the improved math skills were "remarkable," since no math lessons were given as part of the study. This suggests longer, more sustained periods of vigorous physical activity throughout the entire school year could produce even higher results. And researchers believe all children -- not just those who are overweight -- could benefit with improved reasoning and complex thinking skills.

In a country where one-third of our children are overweight, it is increasingly important to motivate schools and parents to encourage daily physical activity. The Center for Disease Control recommends at least 60 minutes of exercise a day for children, yet there is no federal mandate for minimum standards in schools. Each state is responsible for setting their own requirements, and unfortunately, with increasing budget cuts, not all schools comply or engage the children in quality-rich physical education.

A new study adds yet another reason to consider scaling back your soda intake, and it's already putting beverage makers on the defensive. Researchers from the School of Public Health at Imperial College in London analyzed the diets of nearly 2,700 middle-aged people in the U.S. and the U.K. They found that people drinking more than one soda or other sugar-sweetened beverage a day had higher blood pressure, and that it kept going up the more they drank. After accounting for weight and other risk factors, that habit seemed to still put them at greater risk for cardiovascular problems.

The researchers also found that people who drank more than one sugary drink a day consumed nearly 400 more calories than those who didn't. And their diets were more likely to lack key nutrients like potassium, magnesium and calcium. "This is because they're getting the calories from these nutrient-poor sources. All they provide is the calories — none of the benefits of real foods," Brown says.

The new study seems to bolster previous research showing that cutting back even just a serving of soda a day can help lower blood pressure for those most at risk.

"Research shows it's possible to cushion yourself against stress, and the tactics we're using with soldiers also apply to real folks and more common types of anxiety." Key to the recent breakthroughs is a much clearer picture of how destructive stress can be. Persistent anxiety can kill neurons in brain structures concerned with memory and decisionmaking, and such damage is even visible on brain scans.

Fortunately, experts are learning that all along the continuum—from severe anxiety disorders to garden-variety worry—coping and even prevention tactics are highly effective. Here's what new PTSD science can teach all of us about outsmarting stress. If these solutions work for soldiers in Iraq and Afghanistan, they can certainly help the rest of us on the home front.

Researchers are learning that exercise doesn't just soothe stress, it also fortifies brain cells so they're less vulnerable to anxiety in the future.

Children of depressed parents are two to three times as likely to have major depression. Maternal depression in particular has been shown to have serious effects on development, primarily through an absence of responsiveness — the parent’s conscious and consistent mirroring and reciprocity of an infant’s gaze, babble and actions. “Depressed mothers often respond to their babies from the beginning in ways that dampen their enthusiasm and joy,” says Alicia Lieberman, a professor in the department of psychiatry at the University of California, San Francisco. This is problematic, as 10 to 20 percent of mothers go through depression at some point, and 1 in 11 infants experiences his mother’s depression in the first year.

Many researchers, particularly those with medical training, are eager to identify some kind of a “biologic marker” to make diagnosis scientifically conclusive. Recent studies have looked at the activity of cortisol, a hormone the body produces in response to stress. In preschoolers who have had a diagnosis of depression, as in depressed adults, cortisol levels escalate under stressful circumstances and then fail to recover with the same buoyancy as in typical children.

But in adults, cortisol reactivity can be an indication of anxiety. Other research has found that in young children, anxiety and depression are likewise intertwined. At Duke, Egger found that children who were depressed as preschoolers were more than four times as likely to have an anxiety disorder at school age. “Are these two distinct but strongly related syndromes?” asks Daniel Pine of the N.I.M.H. “Are they just slightly different-appearing clinical manifestations of the same underlying problem? Do the relationships vary at different ages? There are no definitive answers.”

People with metabolic syndrome -- a cluster of risk factors for heart disease, stroke and type 2 diabetes -- have a better chance of reversing it if they stick to a healthy diet, a new study shows.

A person is considered to have metabolic syndrome if they have three or more of the following risk factors: excess belly fat; high triglyceride levels (a harmful blood fat); low levels of "good" HDL cholesterol; high blood pressure; and either high blood sugar levels or type 2 diabetes.

According to the National Heart Lung and Blood Institute (NHLBI), having metabolic syndrome doubles a person's risk of heart disease and quintuples their risk of developing type 2 diabetes. Nearly a quarter of US adults have the metabolic syndrome.

Teenagers who are overweight, get little exercise, or smoke may be more likely than their peers to have recurrent headaches, researchers reported Wednesday.

Norwegian researchers found that among nearly 6,000 13- to 18-year-olds they assessed, those who were overweight, sedentary or who smoked were more likely to report suffering recurrent headaches in the past year -- including both migraines and common tension-type headaches.

The human brain never stops adapting to its environment in a quest to formulate what the mind perceives based on what the eyes see, according to a new study. The research adds credence to the notion that adult brains can be retrained following trauma or surgery or even from the effects of aging or eye misalignment, says Jan Brascamp, a research associate working with Randolph Blake, Centennial Professor of Psychology at Vanderbilt University. Details appear in the July 29 issue of Current Biology.

A study by researchers at the National Institutes of Health and the University of Oxford supports the widespread belief that stress may reduce a woman's chance of becoming pregnant. The study is the first of its kind to document, among women without a history of fertility problems, an association between high levels of a substance indicative of stress and a reduced chance of becoming pregnant.

The researchers found that, all other factors being equal, women with high alpha-amylase levels were less likely to conceive than were women with low levels, during the fertile window -- the six days when conception is most likely to occur.

Eating a diet rich in fruits and vegetables and low in saturated fats can significantly lower the risk of heart attack for people with mildly elevated blood pressure, Johns Hopkins University researchers say.

The diet they examined — called the DASH diet (dietary approaches to stop hypertension) — was designed to lower blood pressure and cholesterol. In this new study, it reduced the risk of heart attack by almost 20%, the researchers said.

The diet also calls for reducing fats, red meat, sweets and sugary beverages, and replacing them with whole grains, poultry, low-fat dairy products, fish and nuts.

Studies are finding that more lean muscle mass may allow kidney dialysis patients to live longer, give older people better cognitive function, reduce depression, boost good cholesterol, lessen the swelling and discomfort of lymphedema after breast cancer and help lower the risk of diabetes.

During a strength workout, the heart's muscle tissue contracts forcefully to push the blood out. Like all muscles, stress causes small tears in the muscle fibers. When the body repairs those tears, muscles grow. The result is a stronger heart, not just one that's more efficient at pumping. Another big advantage of working out with weights is improving glucose metabolism, which can reduce the risk of diabetes. Strength training boosts the number of proteins that take glucose out of the blood and transport it into the skeletal muscle, giving the muscles more energy and lowering overall blood-glucose levels.

A 2010 study in the Clinical Journal of the American Society of Nephrology suggested that people on dialysis can benefit from building muscle. Researchers found that kidney dialysis patients who had the most lean muscle mass — a measurement derived from the circumference of the mid-arm muscle — were 37% less likely to die than the patients who had the least.

A growing body of research shows that working out with weights has health benefits beyond simply bulking up one's muscles and strengthening bones. Studies are finding that more lean muscle mass may allow kidney dialysis patients to live longer, give older people better cognitive function, reduce depression, boost good cholesterol, lessen the swelling and discomfort of lymphedema after breast cancer and help lower the risk of diabetes. "Muscle is our largest metabolically active organ, and that's the backdrop that people usually forget," said Kent Adams, director of the exercise physiology lab at Cal State Monterey Bay. Strengthening the muscles "has a ripple effect throughout the body on things like metabolic syndrome and obesity."

Strength training often takes a back seat to cardiovascular training, but it can benefit the heart in ways that its more popular cousin can't. During cardio exercise, the heart loads up with blood and pumps it out to the rest of the body: As a result, Potteiger said, "the heart gets better and more efficient at pumping." But during resistance training, muscles generate more force than they do during endurance exercises, and the heart is no exception, Potteiger said. During a strength workout, the heart's muscle tissue contracts forcefully to push the blood out. Like all muscles, stress causes small tears in the muscle fibers. When the body repairs those tears, muscles grow. The result is a stronger heart, not just one that's more efficient at pumping. Another big advantage of working out with weights is improving glucose metabolism, which can reduce the risk of diabetes. Strength training boosts the number of proteins that take glucose out of the blood and transport it into the skeletal muscle, giving the muscles more energy and lowering overall blood-glucose levels. "If you have uncontrolled glucose levels," Potteiger said, "that can lead to kidney damage, damage to the circulatory system and loss of eyesight."

The brain may get a boost from the body's extra muscle as well. A 2010 study in Archives of Internal Medicine found that women ages 65 to 75 who did resistance training sessions once or twice a week over the course of a year improved their cognitive performance, while those who focused on balance and tone training declined slightly. One reason for the improvement, researchers believe, may be that strength training triggers the production of a protein beneficial for brain growth.

A memory center in the brain called the hippocampus shrinks a little bit each year with age, but older adults who walked routinely for a year actually gained hippocampus volume, researchers report in a study to appear in the Proceedings of the National Academy of Sciences.

In the study, 60 adults aged 55 to 80 scaled up gradually until they walked for 40 minutes three times a week, enough to get their heart rates up. Sixty other participants did toning workouts that included weight training, yoga sessions and stretching for the same amount of time. After a year of toning, a part of these subjects’ brains called the anterior hippocampus lost a little over 1 percent of its volume. In contrast, a year of aerobic exercise led to about a 2 percent increase in anterior hippocampus volume. Study participants who got their heart rates up performed slightly better on a memory test and had higher levels of a brain-aiding molecule called BDNF, the researchers found.

Researchers at Oregon Health and Science University scanned the brains of nine healthy, normal-weight  subjects in the minutes after each got an infusion of equal volumes of glucose, of fructose and of saline. The brain scans aimed to capture activity in a relatively small swath of the human brain in and around the hypothalamus, which plays a key but complex role in setting appetite levels and directing production of metabolic hormones. The researchers, led by Dr. John Purnell, found that "cortical control areas"--broad swaths of gray matter that surrounded the hypothalamus -- responded quite differently to the infusion of fructose than they did to glucose. Across the limited regions of the brain they scanned, Purnell and his colleagues saw that glucose significantly raised the level of neural activity for about 20 minutes following the infusion. Fructose had the opposite effect, causing activity in the same areas to drop and stay low for 20 minutes after the infusion. Saline--the control condition in this trial--had no effect either way.

Being a 'happy' teenager is linked to increased well-being in adulthood, new research finds.

For the first time, researchers from the University of Cambridge and the MRC Unit for Lifelong Health and Ageing have analysed the link between a positive adolescence and well-being in midlife. Using information from 2776 individuals who participated in the 1946 British birth cohort study, the scientists tested associations between having a positive childhood and well-being in adulthood.

teenagers rated positively by their teachers were significantly more likely than those who received no positive ratings to have higher levels of well-being later in life, including a higher work satisfaction, more frequent contact with family and friends, and more regular engagement in social and leisure activities. Happy children were also much less likely than others to develop mental disorders throughout their lives - 60% less likely than young teens that had no positive ratings.

As if the recent prediction that half of all Americans will have diabetes or pre-diabetes by the year 2020 isn't alarming enough, a new genetic discovery published online in the FASEB Journal provides a disturbing explanation as to why: we took an evolutionary "wrong turn." In the research report, scientists show that human evolution leading to the loss of function in a gene called "CMAH" may make humans more prone to obesity and diabetes than other mammals.

"Our study for the first time links human-specific sialic acid changes to insulin and glucose metabolism and therefore opens up a new perspective in understanding the causes of diabetes." In this study, which is the first to examine the effect of a human-specific CMAH genetic mutation in obesity-related metabolism and diabetes, Kim and colleagues show that the loss of CMAH's function contributes to the failure of the insulin-producing pancreatic beta cells in overweight humans, which is known to be a key factor in the development of type 2 diabetes. This gene encodes for an enzyme present in all mammalian species except for humans and adds a single oxygen atom to sialic acids, which are sugars that coat the cell surface

A new study to be presented at the American Academy of Neurology 63rd Annual Meeting in April shows that people with an elevated heart disease risk in middle age were more likely to have associated memory and other cognitive problems. Researchers found that people who have a 10% higher risk of cardiovascular disease were more likely to have lower cognitive function and a faster rate of cognitive decline, compared to people with the lowest risk of heart disease.

The study looked at heart disease risk and cognitive function in more than 4,800 middle-aged men and women in the U.K. who participated in a long-term British study. The participants had their blood pressure, cholesterol, and other heart disease risk factors measured three times over a 10-year period and were also tested on various areas of cognitive function. Researchers found that middle-aged men and women with a 10% higher than average heart disease risk scored lower on all cognitive areas except reasoning for men and fluency for women. For example, a 10% higher heart disease risk was associated with a 2.8% lower score on memory tests among men and a 7.1% lower score among women.