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Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle.
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www.ncbi.nlm.nih.gov/...PMC303514
cortisol
mineralcorticoid
low
potassium
hypokalemia
hypertension
11-betaHSD
shared by
Nathan Goodyear
on 24 Apr 12
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These results suggest that cortisol acts as a potent mineralocorticoid in 11 beta-OHSD deficiency
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major site for the oxidation of cortisol to cortisone is the kidney
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congenital deficiency of 11 beta-OHSD results in high intrarenal cortisol levels which then act on renal type I mineralocorticoid receptors
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...1 more annotation...
deficiency of 11 beta-OHSD results in high intrarenal cortisol concentrations that then bind to the type I receptor.
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Nathan Goodyear
on 24 Apr 12
mechanism of how cortisol acts as a
mineralcorticoid
in those with dysfunctional 11-beta HSD activity.
mechanism of how cortisol acts as a mineralcorticoid in those with dysfunctional 11-beta HSD activity.
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Hypertension and the cortisol-cortis... [J Clin Endocrinol Metab. 2003] - PubMed - NCBI
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www.ncbi.nlm.nih.gov/...12788832
cortisol: cortisone shuttle
cortisol:cortisone
cortisol:cortisone shunt
cortisol
cortisone
11-betaHSD
11beta-HSD2
hypertension
blood
pressure
shared by
Nathan Goodyear
on 03 Jun 14
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No Cached
Nathan Goodyear
on 03 Jun 14
Abstract only available. Cortisol-cortisone shuttle play a role in hypertension. Those with 11betaHSD type II defects will have elevated blood pressure due to increase in
mineralcorticoid
s.
Abstract only available. Cortisol-cortisone shuttle play a role in hypertension. Those with 11betaHSD type II defects will have elevated blood pressure due to increase in mineralcorticoids.
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