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Nathan Goodyear

Out-Patient Screening for Cushing's Syndrome: The Sensitivity of the Combination of Circadian Rhythm and Overnight Dexamethasone Suppression Salivary Cortisol Tests -- Castro et al. 84 (3): 878 -- Journal of Clinical Endocrinology & Metabolism - 0 views

jcem.endojournals.org/...878

hormones hormone saliva testing salivary cortisol

shared by Nathan Goodyear on 20 Nov 10 - No Cached
  • Nathan Goodyear on 20 Nov 10
     
    salivary cortisol recommended for evaluating Cushing's syndrom
Nathan Goodyear

Overnight dexamethasone suppression test: comparis... [Eur J Endocrinol. 1996] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...8590965

saliva testing salivary cortisol

shared by Nathan Goodyear on 20 Nov 10 - No Cached
  • In conclusion we recommend the overnight dexamethasone suppression test with measurement of salivary cortisol as a screening test for Cushing's syndrome.
  • Nathan Goodyear on 20 Nov 10
     
    saliva testing of cortisol preferred for screening for Cushing's syndrome
Nathan Goodyear

A comparison of the use of urinary c... [J Clin Endocrinol Metab. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23150688

cortisol saliva salivary Cushing's testing

shared by Nathan Goodyear on 23 Aug 14 - No Cached
  • Nathan Goodyear on 23 Aug 14
     
    night time salivary cortisol found to correlate with early morning urine samples in those with Cushing's.  This in addition to the nocturnal salivary cortisol correlation found in past studies.  The positive studies on salivary cortisol testing continues to build.
Nathan Goodyear

Midnight Salivary Cortisol for the Initial Diagnosis of Cushing's Syndrome of Various Causes - 0 views

jcem.endojournals.org/...3345.full

saliva salivary cortisol testing gold standard cushing's syndrome cushing's syndrome

shared by Nathan Goodyear on 22 Aug 12 - No Cached
  • Nathan Goodyear on 22 Aug 12
     
    salivary cortisol described as the new "gold standard".  That is saliva.
Nathan Goodyear

Access : Late-night salivary cortisol measurement in the diagnosis of Cushing's syndrome : Nature Reviews Endocrinology - 1 views

www.nature.com/...ncpendmet0837.html

saliva salivary testing hormone evaluation diagnosis cushing's syndrome

shared by Nathan Goodyear on 27 Nov 11 - No Cached
  • Nathan Goodyear on 27 Nov 11
     
    late-night salivary cortisol yields sensitivity of 92-100% and specificity of 93-100%.  Wow!  not much in medicine even approaches this kind of validity.
Nathan Goodyear

Salivary cortisol measurement--a reliable method f... [Exp Clin Endocrinol Diabetes. 2005] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...15891959

hormone testing cortisol saliva salivary

shared by Nathan Goodyear on 03 Nov 10 - No Cached
  • Nathan Goodyear on 03 Nov 10
     
    Salivary cortisol measurement--a reliable method for the diagnosis of Cushing's syndrome.
Nathan Goodyear

Association of Hypertension and Hypokalemia with Cushing's Syndrome Caused by Ectopic ACTH Secretion - TORPY - 2006 - Annals of the New York Academy of Sciences - Wiley Online Library - 0 views

onlinelibrary.wiley.com/...85BD06C2AC6C2355181DC95.d02t04

hypokalemia low potassium cortisol

shared by Nathan Goodyear on 24 Apr 12 - No Cached
  • cortisol may act as a mineralocorticoid when in excess, perhaps by saturating the 11β-hydroxysteroid-dehydrogenase (11β-HSD2 enzyme) that inactivates cortisol at the renal tubule
  • high cortisol levels may be the principal cause of hypokalemic alkalosis
  • Nathan Goodyear on 24 Apr 12
     
    high cortisol, whether exogenous or endogenous, can have a mineral corticoid effect and resultant low potassium.
Nathan Goodyear

Salivary Cortisol Measurement: A Practical Approach to Assess Pituitary-Adrenal Function - 0 views

jcem.endojournals.org/...343.abstract

cortisol saliva salivary testing hormone hormones evaluation Cushing's syndrome adrenal insufficiency

shared by Nathan Goodyear on 30 Apr 12 - No Cached
  • We conclude that salivary cortisol measurements are an excellent index of plasma free cortisol concentrations
  • Nathan Goodyear on 30 Apr 12
     
    this study showed salivary cortisol to be an "excellent" means to evaluate both those with adrenal disease and adrenal dysfunction.  Salivary test is a good tool to evaluate the free active cortisol.
Nathan Goodyear

The Diagnosis of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline - 1 views

www.ncbi.nlm.nih.gov/...PMC2605410

salivary saliva cortisol testing cushing's disease syndrome

shared by Nathan Goodyear on 27 Nov 11 - No Cached
  • the diagnostic sensitivity and specificity is said to be excellent (92–100%)
  • Measurement of salivary cortisol by ELISA and LC-MS/MS has been well validated in the United States
  • Nathan Goodyear on 27 Nov 11
     
    Endocrine society clinical  practice guideline's state proves validity of salivary cortisol testing.  Statement: "the diagnostic sensitivity and specificity is said to be excellent (92-100%)" and " Measurement of salivary cortisol by ELISA and LC-MS/MS has been well validated in the United States"
Nathan Goodyear

Midnight Salivary Cortisol for the Initial Diagnosis of Cushing's Syndrome of Various Causes - 1 views

jcem.endojournals.org/...3345

saliva salivary testing evaluation cortisol hormone hormones BHRT Cushing's syndrome

shared by Nathan Goodyear on 28 Nov 11 - No Cached
  • Measuring midnight salivary cortisol is an easy and noninvasive means of diagnosing hypercortisolism
  • Its diagnostic accuracy is identical to, if not better than, that of previously described gold standards.
  • Nathan Goodyear on 28 Nov 11
     
    midnight salivary cortisol said to be diagnostically as accurate if not better than previous gold standards
Nathan Goodyear

Advantage of salivary cortisol measurements in the... [Clin Biochem. 2008] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...18280810

hormone testing saliva salivary cortisol

shared by Nathan Goodyear on 03 Nov 10 - No Cached
  • Morning salivary cortisol is as good as serum as screening test for patients with Addison's disease and nighttime salivary cortisol is more adequate than serum in the screening of Cushing's syndrome.
  • Nathan Goodyear on 03 Nov 10
     
    Advantage of salivary cortisol measurements in the diagnosis of glucocorticoid related disorders.
Nathan Goodyear

Utility of salivary cortisol measurements in Cushi... [J Clin Endocrinol Metab. 2009] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...19602555

saliva salivary cortisol hormone testing

shared by Nathan Goodyear on 13 Jul 11 - No Cached
  • Measurement of an elevated late-night (2300 to 2400 h) salivary cortisol has a greater than 90% sensitivity and specificity for the diagnosis of endogenous Cushing's syndrome
  • It is expected that the use of the measurement of salivary cortisol will become routine in the evaluation of patients with disorders of the HPA axis.
  • Nathan Goodyear on 13 Jul 11
     
    Saliva cortisol testing validated again.  Without saying, the author essentially calls it the gold standard
Nathan Goodyear

Late-night salivary cortisol measurement in the di... [Nat Clin Pract Endocrinol Metab. 2008] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...18446140

saliva salivary hormone testing cortisol sensitivity specificity

shared by Nathan Goodyear on 12 Jul 11 - No Cached
  • Late-night salivary cortisol measurement yields excellent overall diagnostic accuracy for Cushing's syndrome, with a sensitivity of 92-100% and a specificity of 93-100%
  • Nathan Goodyear on 12 Jul 11
     
    Saliva testing shown to be 92-100% sensitive and 93-100% specific.  I challenge you to find any test that approaches these levels.
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