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spineneuro

Dr Sandeep Vaishya in India Brings Newest Radiosurgery Therapy - 0 views

www.briefingwire.com/...gs-newest-radiosurgery-therapy

gamma knife radiosurgery gamma knife radiosurgery hospitals in India Dr. Sandeep Vaishya best gamma knife neurosurgeon in India Best Neurourgeon at Fortis Hospital Delhi

shared by spineneuro on 03 Nov 21 - No Cached
  • spineneuro on 03 Nov 21
     
    "Since 2011 gamma knife radiosurgery hospitals in India have treated more than 1,400 patients with gamma knife," stated Dr. Sandeep Vaishya best gamma knife neurosurgeon in India. Often known as "surgical operation without a knife," gamma knife exactly grants radiation to the focused affected place, maintaining healthy brain tissue and casting off some of the risks of a traditional craniotomy, like bleeding or brain damage. For Consultation Email: dr.sandeepvaishya@neurospinehospital.com Phone No:- +91-9325887033
Nathan Goodyear

Intravenous Vitamin C Administration Improves Quality of Life in Breast Cancer Patients during Chemo-/Radiotherapy and Aftercare: Results of a Retrospective, Multicentre, Epidemiological Cohort Study in Germany - 0 views

iv.iiarjournals.org/...983.abstract

vitamin C IV intravenous therapy treatment cancer

shared by Nathan Goodyear on 14 Nov 11 - No Cached
  • Nathan Goodyear on 14 Nov 11
     
    IV vitamin C shown to improve quality of life measures in breast cancer patients during chemo/radiation.  What this shows, is that IV vitamin C is not only safe for healthy individuals, but healthy for cancer patients.
Nathan Goodyear

Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism - 1 views

www.sciencedirect.com/...S2213231714000925

ketogenic diet cancer nutrition

shared by Nathan Goodyear on 03 Feb 16 - No Cached
  • Nathan Goodyear on 03 Feb 16
     
    review of science and mechanisms of ketogenic diet and cancer.
Nathan Goodyear

Hyperbaric oxygen therapy and cancer-a review - 0 views

www.ncbi.nlm.nih.gov/...PMC3510426

HBOT hyperbaric hyperbaric oxygen cancer

shared by Nathan Goodyear on 13 Nov 14 - No Cached
  • Nathan Goodyear on 13 Nov 14
     
    review of Hyperbaric oxygen in cancer.  
Nathan Goodyear

Hyperthermia as an immunotherapy strategy for cancer - 1 views

www.ncbi.nlm.nih.gov/...PMC2828267

cancer hyperthermia

shared by Nathan Goodyear on 29 Nov 18 - No Cached
  • the notion of treating human cancers with heat dates back to the writings of Hippocrates
  • enhance the efficiency of standard cancer therapies, such as chemotherapy and radiation treatment
  • After antigen uptake at tumor sites, APCs have the ability to create a robust response by entering lymphoid compartments and programming lymphocytes
  • ...36 more annotations...
  • Hyperthermia differs fundamentally from fever in that it elevates the core body temperature without changing the physiological set point
  • hyperthermia is induced by increasing the heat load and/or inactivating heat dissipation
  • mor cells [2]. Although significant cell killing could be achieved by heating cells or tissues to temperatures > 42°C for 1 or more hours, the application, measurement and consistency of this temperature range within the setting of cancer clinical trials
  • mild temperature hyperthermia (ie, within the fever-range, 39–41°C)
    • Nathan Goodyear
      Nathan Goodyear on 04 Aug 19
       
      101.2 to 105.8
  • moderate hyperthermia (41°C)
    • Nathan Goodyear
      Nathan Goodyear on 04 Aug 19
       
      105.8 F
  • Hsps are a family of stress-induced proteins
  • they are key regulators of cellular protein activity, turnover and trafficking
  • Hsps ensure appropriate post-translational protein folding, and are able to refold denatured proteins, or mark irreversibly damaged proteins for destruction
  • the ability of fever-range hyperthermia to induce reactive immunity against tumor antigens through DCs and NK-cells is likely mediated by Hsps
  • thermotolerance
  • Hsps support the malignant phenotype of cancer cells by not only affecting the cells’ survival, but also participating in angiogenesis, invasion, metastasis and immortalization mechanisms
  • Hsps released from stressed or dying cells activate dendritic cells (DCs), transforming them into mature APCs
  • In theory, fever-range hyperthermia may take advantage of tumor cell Hsps by inducing their release from tumor cells and augmenting DC priming against tumor antigens
  • In several models of hyperthermia, heat-treated tumors exhibited improved DC priming and generation of systemic immunity to tumor cell
  • hyperthermia alone can enhance antigen display by tumor cells, thus rendering them even more susceptible to programmed immune clearance
  • Fever-range hyperthermia may also induce Hsps
  • Hsps may exert an adjuvant effect by bolstering MHC class II and co-stimulatory molecule expression by DCs
  • thermal ablation of liver tumors in particular has demonstrated an ability to potentiate immune responses [57, 58] and elicit robust T-cell infiltrates at ablation sites
  • specific Hsp, Hsp70, directly inhibits apoptosis pathways in cancer cells, as demonstrated in human pancreatic, prostate and gastric cancer cells
  • Cross-priming is the ability of extracellular Hsps complexed to tumor peptides to be internalized and presented in the context of MHC class I molecules on APCs, thus allowing potent priming of CTLs against tumor antigens
  • It has been reported that Hsps are generated from necrotic tumor cell lysates, but not from tumor cells undergoing apoptosis
  • tumor cells exposed to hyperthermia in the heat shock range (42°C for 4h) prior to lysing, DC activation and cross-priming were significantly enhanced with the application of heat
  • Due to the ability of Hsps to activate DCs directly by chaperoning tumor antigens upon their release [28], it is possible that both local and regional immune stimulation can be achieved with hyperthermia.
  • support the use of hyperthermia as an inducer of Hsps to serve as ‘danger signals’, activating antitumor immune responses
  • whole-body hyperthermia not only augments immune responses, but also stimulates the migration of skin-derived DCs to draining lymph nodes
    • Nathan Goodyear
      Nathan Goodyear on 04 Aug 19
       
      This allows for the activation of lymphocytes by the activated dendritic cells.
  • suggest a valuable role of hyperthermia in DC cancer vaccine strategies
  • In mice treated with fever-range whole-body hyperthermia, tumor growth was significantly inhibited and NK-cell infiltration increased
    • Nathan Goodyear
      Nathan Goodyear on 04 Aug 19
       
      Hyperthermia increased NK cell activation, proliferation, and infiltration, which equals increased cytotoxicity.
  • exposure to fever-range hyperthermia resulted in improved endogenous NK-cell cytotoxicity to several cancer types
  • improved activation and function of DCs and NK cells following hyperthermia
  • Hyperthermia increases the expression ICAM-1 a key adhesion molecule,
  • The combined effects of hyperthermia on lymphoid tissue endothelium and lymphocytes can promote immune surveillance and increase the probability of naive lymphocytes leaving the circulation and encountering their cognate antigen displayed by DCs in lymphoid organs.
  • In independent clinical studies, whole-body hyperthermia resulted in a transient decrease in circulating lymphocytes in patients with advanced cancer [12, 94, 99, 100], a finding which mirrored observations in animal models in which lymphocyte entry into lymph noeds was increased following hyperthermia treatment [93]. Enhanced recruitment of lymphocytes to lymphoid tissues may be exploited in the treatment of malignancies.
  • The initial tumor antigen presentation and initiation of clonal expansion of CTLs transpires in the lymph nodes and cannot take place outside this specialized compartment
  • the ability of DCs present in the lymph nodes to stimulate an anti-tumor immune response is critical
  • hyperthermia has been shown to improve immune surveillance by T-cell
  • and to increase DC trafficking to lymph nodes
  • Nathan Goodyear on 29 Nov 18
     
    Great review of hyperthermia.
Nathan Goodyear

BEMER Electromagnetic Field Therapy Reduces Cancer Cell Radioresistance by Enhanced ROS Formation and Induced DNA Damage - 0 views

www.ncbi.nlm.nih.gov/...PMC5154536

radiation Cancer Bemer

shared by Nathan Goodyear on 15 Nov 18 - No Cached
  • Nathan Goodyear on 15 Nov 18
     
    Bemer increased radiosensitization of cancer cells.
Nathan Goodyear

The interaction of anticancer therapies with tumor-associated macrophages - 0 views

www.ncbi.nlm.nih.gov/...PMC4387285

radiation tumor microenvironment TME chemotherapy M2 macrophages

shared by Nathan Goodyear on 04 Oct 20 - No Cached
  • Nathan Goodyear on 04 Oct 20
     
    Chemotherapy induces TME M2 polarization
Nathan Goodyear

Utilization of Pharmacological Ascorbate to Enhance Hydrogen Peroxide-Mediated Radiosensitivity in Cancer Therapy - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC8509557

radiation fenton reaction High dose IV vitamin C vitamin C ascorbic acid high dose vitamin C H2O2 pharmacologic vitamin C

shared by Nathan Goodyear on 11 Aug 22 - No Cached
  • Nathan Goodyear on 11 Aug 22
     
    Conclusion: the data presented in this review show synergistically increased DNA damage with combination treatment of RT and P-AscH−, associated with H2O2 formation
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