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This was a meta-analysis looking at the time frame of effects by Testosterone.  For most, positive effects are seen at 3-6 weeks, but the majority maximum benefits not seen for 3-6 months.  A realistic timeline is 3-4 months to assess physiologic benefit of Testosterone therapy in those with low T.  That is the key--that they have document low T.

Study finds ER and PR increase along the timeline of tumor initiation.  The authors point to likely association that ER and PR expression is associated with and key to initiating colorectal transformation.  A lot to be determined from this study.  IF this were entirely true, then what to explain the 35% lower colorectal cancer risk in women vs men?  Likely ER and PR pertubance plays a significant role is likely, but the mere expression--yet to be determined.

Good, up to date, review of the MGUS and the timeline to multiple myeloma.